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Vaping Alone May Boost Lung Troubles


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In a web-based survey involving more than 2,900 teens and young adults, electronic cigarette use was associated with shortness of breath and other respiratory events, even among those who did not smoke combustible cigarettes or use marijuana.
After controlling for demographic characteristics and multi-product use, past 30-day e-cigarette use was associated with an increased odds of self-reported wheezing and shortness of breath, reported Alayna Tackett, PhD, of the Keck School of Medicine at the University of Southern California in Los Angeles, at the American Thoracic Society (ATS) virtual meeting.
Tackett told
MedPage Today that previous observational studies have shown associations between e-cigarette, combustible cigarette, and marijuana use and respiratory symptoms, such as asthma, wheeze, and shortness of breath. But many did not attempt to tease out the impact of concurrent combustible cigarette and/or marijuana use in e-cigarette users. ....

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VUMC to lead national study to treat severe COVID complications


by Bill Snyder
The Vanderbilt Institute for Clinical and Translational Research (VICTR) has been awarded a major federal grant to lead a national trial of treatments targeting the Renin Angiotensin Aldosterone System (RAAS) in patients hospitalized with COVID-19.
Comprised of the hormones renin, angiotensin and aldosterone, RAAS is essential for the regulation of blood pressure and fluid balance. SARS-CoV-2, the virus that causes COVID-19, can disrupt this system, resulting in life-threatening complications, including pulmonary edema, thromboembolic complications and severe cardiac injury.
Sean Collins, MD, MSc, professor of Emergency Medicine at Vanderbilt University Medical Center, who has deep expertise in emergency care and RAAS, will lead the trial, which will test whether drugs targeting RAAS can prevent the vascular, fibrotic and inflammatory consequences of severe COVID-19 disease. ....

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