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Flipping a Molecular Switch for Heart Fibrosis

Flipping a Molecular Switch for Heart Fibrosis
prnewswire.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from prnewswire.com Daily Mail and Mail on Sunday newspapers.

United States , San Simeon , San Francisco , Yu Huang , Rudi Micheletti , Irina Sattui , Michael Rosenfeld , Katie Pollard , Qiming Duan , Sanjeev Ranade , Deepak Srivastava , Gaia Andreoletti , Ricardo Linares Saldana , Michael Alexanian , Saptarsi Haldar , Nandhini Sadagopan , Clara Yougna Lee , Rajan Jain , Pawel Przytycki , Bishow Adhikari , Franco Felix , Arun Padmanabhan , Timothy Mckinsey , Catarina Silva , Casey Gifford , Angelo Pelonero ,

Do our brains age faster than the rest of our bodies?

Do our brains age faster than the rest of our bodies?
April 21, 2021USC
If you feel your brain power diminishing as you advance into middle age and beyond, blame your neural stem cells. In a new study published in
Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi demonstrates that neural stem cells the stem cells of the nervous system age rapidly.
“There is chronological aging, and there is biological aging, and they are not the same thing,” said Bonaguidi, an Assistant Professor of Stem Cell Biology and Regenerative Medicine, Gerontology and Biomedical Engineering at the Keck School of Medicine of USC. “We’re interested in the biological aging of neural stem cells, which are particularly vulnerable to the ravages of time. This has implications for the normal cognitive decline that most of us experience as we grow older, as well as for dementia, Alzheimer’s disease, epilepsy and brain injury.” ....

United States , United Kingdom , Los Angeles , Daniel Aaron , Heechul Jun , Galen Resler , Mi Hyeon Jang , Elbert Pu , Benjamind Simons , Naibo Zhang , Albina Ibrayeva , David Jorg , Axel Hidalgo , Congrui Lin , Michael Bonaguidi , Stem Cell Research , National Institutes Of Health , Deliab Baxter Foundation , Mayo Clinic College Of Medicine , Keck School Of Medicine , Bonaguidi Lab , University Of Cambridge , Provost Research Enhancement Fellowship , Royal Societyep Abraham Professorship , Edythe Broad Foundation , Edythe Broad Center ,

USC Stem Cell study reveals neural stem cells age rapidly

Credit: Albina Ibrayeva/Bonaguidi Lab
In a new study published in
Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi, PhD, demonstrates that neural stem cells - the stem cells of the nervous system - age rapidly.
There is chronological aging, and there is biological aging, and they are not the same thing, said Bonaguidi, an Assistant Professor of Stem Cell Biology and Regenerative Medicine, Gerontology and Biomedical Engineering at the Keck School of Medicine of USC. We re interested in the biological aging of neural stem cells, which are particularly vulnerable to the ravages of time. This has implications for the normal cognitive decline that most of us experience as we grow older, as well as for dementia, Alzheimer s disease, epilepsy and brain injury. ....

United States , United Kingdom , Los Angeles , Daniel Aaron , Heechul Jun , Galen Resler , Mi Hyeon Jang , Elbert Pu , Benjamind Simons , Naibo Zhang , Albina Ibrayeva , David Jorg , Axel Hidalgo , Congrui Lin , Michael Bonaguidi , Stem Cell Research , National Institutes Of Health , Deliab Baxter Foundation , Mayo Clinic College Of Medicine , Keck School Of Medicine , Bonaguidi Lab , University Of Cambridge , Provost Research Enhancement Fellowship , Royal Societyep Abraham Professorship , Edythe Broad Foundation , Edythe Broad Center ,

A potential therapy for one of the leading causes of heart disease

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SAN FRANCISCO, CA December 10, 2020 Calcific aortic valve disease is not only the most common valve disease in the elderly, it s also the third leading cause of heart disease overall. For those affected, calcium starts to accumulate in their heart valves and vessels over time, until they harden like bone. As a result, blood flow out of the heart s pumping chamber to the body gets obstructed, leading to heart failure. Yet no medical therapy currently exists. All patients can do is wait for the calcification (or hardening) to become bad enough that they need surgery to replace their valve.
After 15 years of unrelenting work, a team of scientists from Gladstone Institutes has now discovered a potential drug candidate for heart valve disease that works in both human cells and animals and is ready to move toward a clinical trial. Their findings were just published in the journal ....

United States , Saratovskaya Oblast , Yu Zhang , Yu Huang , Vladimir Uspensky , Sanjeevs Ranade , Tomohiro Nishino , Christinav Theodoris , Aleksandra Kostina , Caseya Gifford , Anna Malashicheva , Roddenberry Stem Cell Center Deepak Srivastava , Russian Academy Of Sciences , American Heart Association , National Center , Almazov Federal Medical Research Centre , Harvard Medical School , Roddenberry Foundation , Research Resources , Younger Family Fund , Department Of Pediatrics , California Institute Of Regenerative Medicine , Blood Institute , National Heart , Uehara Memorial Foundation , Lk Whittier Foundation ,