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Pharma lab seems to contradict itself, science in fight to bleed SC horseshoe crabs

Pharma lab seems to contradict itself, science in fight to bleed SC horseshoe crabs
Chiara Eisner, The State (Columbia, S.C.)
May 19 A judge banned horseshoe crab harvesting on Cape Romain, then Charles River appealed. Here s what the lab is arguing in court, sometimes seemingly at odds with science and experts.
A federal judge has prohibited the harvest of horseshoe crabs in the Cape Romain National Wildlife Refuge near Charleston. The new order was expected to restrict the operations of a Massachusetts-based biomedical company, Charles River Laboratories, that for almost 30 years has purchased tens of thousands of the animals from fishermen who collect them on the refuge and other spots along the S.C. coast. ....

Charleston , South-carolina , United-states , Cape-romain-national-wildlife-refuge , Argentina , Massachusetts , Charles-river , Cape-romain , Canada , Hilton-head-island , America , Canadian

Exploring G Protein-Coupled Receptor signaling in pancreatic islets as targets for diabetes and its complications

Summary
The prevalence of type 2 diabetes has risen dramatically during recent decades and there is an urgent need to develop new approaches for therapeutic treatment that provide a combination of benefits, with fewer side effects and better patient outcomes. When diabetes is not managed, it can lead to serious complications including cardiovascular disease (CVD), stroke, blindness, kidney disease and premature mortality. CVD is a major cause of death and disability in diabetes, accounting for 52% of fatalities in those with type 2 diabetes.
New treatments are necessary due to the increasing prevalence of diabetes and its complications. In recent years, therapies that target the actions of glucagon-like peptide-1 (GLP-1) which stimulate insulin secretion through activation of beta cell G protein-coupled receptors (GPCRs) have been successful. This has resulted in substantial interest in targeting other islet GPCRs for diabetic therapies [1-3]. GPCRs are a superfamily of tr ....

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