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Antibodies Deplete Cancer Cells in Mice and Human Cell Lines


Antibodies Deplete Cancer Cells in Mice and Human Cell Lines
by Angela Mohan on 
March 2, 2021 at 12:14 PM
Science,
Science Immunology.
Some immunotherapy approaches against cancers rely on common cancer-related mutations to serve as antigens; they instigate an immune response to the cancer.
Although it is one of the most common mutant tumor suppressor genes known in human cancers, the cancer-related p53 tumor suppressor gene has not been successfully targeted via this approach.
In
Science, Emily Han-Chung Hsiue and colleagues successfully engineered a bispecific antibody to reactivate p53. Hsiue et al. first identified a distinct targetable fragment of the mutant tumor suppressor protein and characterized the structural basis for how the fragment is presented to T cells. ....

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Ay, there's the rub! Functional Challenges and Opportunities for Hemp Cannabidiol (CBD) External Analgesic Rubs : Biofuels Digest


By Ronald Newman, PhD, Lee Enterprises Consulting
Special to The Digest
Summary
The 2020 declared US market for consumer products made from hemp-derived phytocannabinoid extracts is expected to be close to $1billion, with the most significant consumption occurring in the State of California (projected from 2019 data by Statista, Inc). Growth in 2020 was relatively flat compared to 2019 owing to the downturn in the economy and the growing gap between anticipated performance and actual results
(1). The overall trend is illustrated in Figure 1. Further, there has been a greater shift towards e-commerce compared to the previous year. The largest segment of the hemp CBD market is currently in dietary supplements, followed by topical application products, and then food & beverage additives. ....

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The Health Benefits of the Parsley Veggie Family ~ The Paleo Mom


About Dr. Sarah Ballantyne, PhD
Award-winning public speaker, New York Times bestselling author and world-renowned health expert, Dr. Sarah Ballantyne, PhD (aka The Paleo Mom) believes the key to reversing the current epidemics of chronic disease is scientific literacy. She creates educational resources to help people regain their health through diet and lifestyle choices informed by the most current evidenced-based scientific research.
The parsley family (also known as the
Apiaceae family or umbellifers, due to forming umbrella-like stem structures called umbels) is a huge plant group with over 3,700 species, some of which are familiar names in our kitchen: carrots, parsnips, and celery! That’s right; these diverse veggies are all closely related. (We’ll be looking at other members of this family angelica, anise, caraway, coriander, cumin, dill, fennel, and of course, parsley in more detail in an upcoming post on herbs and spices.) ....

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