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NTU scientists design new compound that could help reduce overactive immune response

NTU scientists design new compound that could help reduce overactive immune response
When the body detects a pathogen, such as bacteria or viruses, it mounts an immune system response to fight this invader. In some people, the immune system overreacts, resulting in an overactive immune response that causes the body to injure itself, which may prove fatal in some cases.
Now, scientists from Nanyang Technological University, Singapore (NTU Singapore) have created a compound that could help to reduce this overactivation without impairing the body s entire immune response.
An overactive immune system leads to many autoimmune disorders - when the immune system mistakenly attacks healthy tissues - such as rheumatoid arthritis and type 1 diabetes. More recently, it has also been linked to severe COVID-19 infections, in which immune-system signalling proteins ramp up to dangerous levels, leading to damage to the body s own cells. ....

United States , Phan Anh Tuan , Emily Henderson , American Association Of Immunologists , Nanyang Technological University , Mathematical Sciences , Institute Of Structural Biology , University Of Edinburgh , Professor Phan Anh Tuan , Structural Biology , Lim Kah Wai , United Kingdom Led , American Association , Immune Response , Immune System , Rheumatoid Arthritis , Type 1 Diabetes , ஒன்றுபட்டது மாநிலங்களில் , ஃப்யாந் அந்த் ட்யூவாந் , எமிலி ஹென்டர்சன் , அமெரிக்கன் சங்கம் ஆஃப் நோயெதிர்ப்பு நிபுணர்கள் , கணித அறிவியல் , நிறுவனம் ஆஃப் கட்டமைப்பு உயிரியல் , பல்கலைக்கழகம் ஆஃப் எடின்பர்க் , ப்ரொஃபெஸர் ஃப்யாந் அந்த் ட்யூவாந் , கட்டமைப்பு உயிரியல் ,

Whole genome sequencing may guide blood cancer treatment

Whole genome sequencing may guide blood cancer treatment
For certain blood cancers, such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), deciding whether patients need an aggressive treatment typically hinges on a set of lab tests to identify genetic changes.
Some of these tests rely on technology that was invented more than 60 years ago and has been used clinically for the past three decades.
Now, a new study from Washington University School of Medicine in St. Louis shows that whole genome sequencing is at least as accurate and often better than conventional genetic tests that help determine the treatment for a patient s blood cancer. Genome sequencing technology continuously is decreasing in cost and recently reached a level similar to that of conventional testing. In addition, results can be returned to patients in just a few days, making whole genome sequencing a potentially viable approach for determining the best treatment regimen for a parti ....

Ericj Duncavage , Mollyc Schroeder , Peter Campbell , Davidh Spencer , Emily Henderson , Mcdonnell Genome Institute , Washington University , Siteman Cancer Center At Barnes , Wellcome Sanger Institute In Cambridge , Washington University School Of Medicine , Siteman Cancer Center , Department Of Pathology Immunology , Washington University School , New England Journal , Study Senior Author , Assistant Professor , Medical Director , Clinical Sequencing Facility , Mcdonnell Genome , Barnes Jewish Hospital , Siteman Cancer , Wellcome Sanger Institute , Blood Cancer , Whole Genome Sequencing , Acute Myeloid Leukemia , Bone Marrow ,

VEXAS syndrome in men is more common than previously thought

VEXAS syndrome in men is more common than previously thought
A rare disease first identified in 2020 is much more common than first thought, say researchers at the University of Leeds investigating its origins.
VEXAS syndrome is a serious inflammatory condition which develops in men over 50, causing them to become very sick and fatigued, and can be fatal. It was originally thought to be rare, but a new study has identified genetic mutations which indicate that the disease is actually much more common.
The researchers developed a genetic test to identify patients who may have the disease, and now want to screen more people showing symptoms to understand exactly how common it is. ....

United Kingdom , Sinisa Savic , James Poulter , Emily Henderson , School Of Medicine , European Reference Network , University Of Leed School Medicine , University Of Leeds , Clinical Associate Professor , Leed School , Honorary Consultant , Leeds Teaching Hospitals , Academic Fellow , Molecular Neuroscience , Clinical Immunology , Bone Marrow , Rare Disease , Sex Chromosome , ஒன்றுபட்டது கிஂக்டம் , எமிலி ஹென்டர்சன் , பள்ளி ஆஃப் மருந்து , ஐரோப்பிய குறிப்பு வலைப்பின்னல் , பல்கலைக்கழகம் ஆஃப் லீட் பள்ளி மருந்து , பல்கலைக்கழகம் ஆஃப் லீட்ஸ் , மருத்துவ இணை ப்ரொஃபெஸர் , லீட் பள்ளி ,

Study uncovers 50 new genes for eye color

Study uncovers 50 new genes for eye color
The genetics of human eye color is much more complex than previously thought, according to a new study published today.
An international team of researchers led by King s College London and Erasmus University Medical Center Rotterdam have identified 50 new genes for eye color in the largest genetic study of its kind to date. The study, published today in
Science Advances, involved the genetic analysis of almost 195,000 people across Europe and Asia.
These findings will help to improve the understanding of eye diseases such as pigmentary glaucoma and ocular albinism, where eye pigment levels play a role. ....

City Of , United Kingdom , Manfred Kayser , Pirro Hysi , Emily Henderson , King College London , Erasmus University Medical Center Rotterdam , College London , Science Advances , Co Senior Author , நகரம் ஆஃப் , ஒன்றுபட்டது கிஂக்டம் , ம்யாந்ஃப்ரெட் கய்சேர் , எமிலி ஹென்டர்சன் , கிங் கல்லூரி லண்டன் , ஈராஸ்மஸ் பல்கலைக்கழகம் மருத்துவ மையம் ரோட்டர்டாம் , கல்லூரி லண்டன் , இணை மூத்தவர் நூலாசிரியர் ,

Could an "ACE2 Triple Decoy" be an alternative approach to neutralizing SARS-CoV-2?

A team of scientists from the USA recently developed a recombinant “Angiotensin converting enzyme 2 (ACE2) Triple Decoy” that can trap SARS-CoV-2 and prevent its propagation inside the host cell. ....

United States , Sanchari Sinha Dutta , Image Credit , Coronavirus Disease Covid 19 , Sars Cov 2 , Binding Affinity , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , சஞ்சரி சீன்ஹா தத்தா , படம் கடன் , பிணைப்பு இன உறவு , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,