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A genetic variant of TMPRSS2 may confer protection against severe COVID-19


A genetic variant of TMPRSS2 may confer protection against severe COVID-19
Among a large sample of coronavirus disease 2019 (COVID-19) patients, researchers found that a genetic variant – caused by an amino acid substitution from valine to methionine – is associated with a reduced chance of severe disease.
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, can have a diverse range of effects on people. Some people develop no symptoms; some have mild fever, sore throat, among other symptoms; whereas in others, the infection becomes more severe and often fatal.
Apart from age, gender, and other diseases, genetics has also emerged as another determinant of COVID-19 severity. Genetic variants involved in the regulation of interferon immunity are associated with severe COVID-19. Genome-wide association studies (GWAS) have identified several genetic groups associated with severe COVID-19. ....

Lakshmi Supriya , Phd Mar , Billion Photos , East Asian , South Asian , South Asians , Coronavirus Disease Covid 19 , Sars Cov 2 , Amino Acid , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Sore Throat , Spike Protein , லட்சுமி சுப்ரியா , ஃப்ட் மார் , பில்லியன் புகைப்படங்கள் , கிழக்கு ஆசிய , தெற்கு ஆசிய , தெற்கு ஆசியர்கள் , அமினோ அமிலம் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , புண் தொண்டை , ஸ்பைக் ப்ரோடீந் ,

Researchers report zoonotic spillover of adapted SARS-CoV-2 from minks to humans


Researchers report zoonotic spillover of adapted SARS-CoV-2 from minks to humans
In a recent report made available on
bioRxiv preprint server, researchers from Poland and Finland reveal a spillover event of mink-adapted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from farmed mink to humans after an extensive adaptation process.
st century (after SARS-CoV and MERS-CoV viruses).
And while mass vaccination activities against COVID-19 are currently underway on a global level, we are still not yet sure how this pandemic (and its causative virus) will end. In other words, highly touted concepts of herd immunity and viral eradication are increasingly seen as unrealistic when prevalence, genetic diversity and pervasive animal reservoirs are taken into account. ....

Lukasz Rabalski , University Of Gdansk , National Veterinary Research Institute , Intercollegiate Faculty , Medical University , Northern Poland , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Mers Cov , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , தேசிய கால்நடை ஆராய்ச்சி நிறுவனம் , இண்டெற்கொள்ளேகியதே ஆசிரிய , மருத்துவ பல்கலைக்கழகம் , வடக்கு போல்யாஂட் , சர்வதேச பரவல் , கொரோனா வைரஸ் , மேற்ச் கோவ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Study shows how mutant huntingtin protein triggers brain cell death


Study shows how mutant huntingtin protein triggers brain cell death
In 1993, scientists discovered that a single mutated gene, HTT, caused Huntington s disease, raising high hopes for a quick cure. Yet today, there s still no approved treatment.
One difficulty has been a limited understanding of how the mutant huntingtin protein sets off brain cell death, says neuroscientist Srinivasa Subramaniam, Ph.D., of Scripps Research, Florida.
In a new study published in
Nature Communications on Friday, Subramaniam s group has shown that the mutated huntingtin protein slows brain cells protein-building machines, called ribosomes.
The ribosome has to keep moving along to build the proteins, but in Huntington s disease, the ribosome is slowed. The difference maybe two, three, four-fold slower. That makes all the difference. ....

United States , Srinivasa Subramaniam , Emily Henderson , Scripps Research , Scripps Research Institute , Nature Communications On , Nature Communications , Huntington 39s Disease , Brain Cell , Cell Death , Protein Synthesis , ஒன்றுபட்டது மாநிலங்களில் , ஸ்ரீநிவாச சுப்ரமணியம் , எமிலி ஹென்டர்சன் , ஸ்கிரிப்ட்கள் ஆராய்ச்சி , ஸ்கிரிப்ட்கள் ஆராய்ச்சி நிறுவனம் , இயற்கை தகவல்தொடர்புகள் ஆன் , இயற்கை தகவல்தொடர்புகள் , மூளை செல் , செல் இறப்பு , ப்ரோடீந் தொகுப்பு ,

Researchers find new way to prevent attention deficits associated with Fragile X syndrome


Researchers find new way to prevent attention deficits associated with Fragile X syndrome
Mount Sinai Researchers find a new way to prevent attention deficits associated with Fragile X, a leading genetic cause of autism, in an animal model.
Corresponding author:
Hirofumi Morishita, MD, Ph.D., Department of Psychiatry, Neuroscience, Friedman Brain Institute, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York.
Bottom line:
The adolescent maturation of the frontal cortex is important for establishing cognitive function, and disruption of this process is associated with neurodevelopmental disorders.
This study uncovered a new molecular driver of frontal circuit maturation that is essential for cognitive function, and demonstrated, in an animal model, that this mechanism can be targeted to restore attention deficits caused by a leading genetic cause of autism. ....

New York , United States , Hirofumi Morishita , Emily Henderson , Icahn School Of Medicine At Mount Sinai , Mount Sinai School Of Medicine , Development Institute , Mindich Child Health , Friedman Brain Institute , Department Of Psychiatry , Sinai Researchers , Icahn School , Mount Sinai , Mount Sinai School , Animal Model , Child Health , Cognitive Function , Fragilex Syndrome , Mouse Model , Top Down , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , ஹிரோபூமி மோரிஷிதா , எமிலி ஹென்டர்சன் , இக்ஹ்ன் பள்ளி ஆஃப் மருந்து இல் ஏற்ற சினை , ஏற்ற சினை பள்ளி ஆஃப் மருந்து ,