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Opinion: Black San Franciscans really need to get vaccinated

Opinion: Black San Franciscans really need to get vaccinated
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UCSF launches new initiative to propel the development of living therapeutics

UCSF launches new initiative to propel the development of living therapeutics
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Cell therapy 'jigsaw puzzle' fits together in $250M UCSF initiative - San Francisco Business Times

Cell therapy 'jigsaw puzzle' fits together in $250M UCSF initiative - San Francisco Business Times
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Smart Cell Therapies for Solid Cancers Ready to Move Towards Clinical Trials

MRI of glioblastomas.
Immunotherapies that fight cancer have been a life-saving advancement for many patients, but the approach only works on a few types of malignancies, leaving few treatment options for most cancer patients with solid tumors. Now, in two related papers published April 28, 2021, in Science Translational Medicine, researchers at UCSF have demonstrated how to engineer smart immune cells that are effective against solid tumors, opening the door to treating a variety of cancers that have long been untouchable with immunotherapies.
By “programming” basic computational abilities into immune cells that are designed to attack cancer, the researchers have overcome a number of major hurdles that have kept these strategies out of the clinic up to now. The two new papers show that the resulting “smart” therapies are more precise, flexible and thorough than previous approaches, and the researchers say that their approach may be ready for clinical trials in the ....

United States , San Francisco , Kiram Downey , Wei Yu , Jasonm Duecker , Kole Roybal , Olga Troyanskaya , Ruth Dannenfelser , Juliem Garcia , Diegoa Carrera , Axel Hyrenius Wittsten , Wendell Lim , Ryand Gilbert , Hideho Okada , Jessicad Briones , Nathaniel Perry , Anna Celli , Josephh Choe , Miloss Simic , Yitzhare Goretsky , Garrett Montgomery , Sachdevs Sidhu , Josef Alavi , Yang Su , Aileenw Li , Juhyun Cho ,

SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models

Science for just $15 USD.
Short circuiting solid tumors
Two major hurdles in chimeric antigen receptor (CAR) T cell therapy for solid tumors are ensuring specificity to tumor cells without affecting healthy cells and avoiding tumor escape due to antigen loss. To address these challenges, Hyrenius-Wittsten
et al. and Choe
et al. developed synthetic Notch (synNotch)–CAR T cells targeting solid tumor antigens and used them to treat mouse models of mesothelioma, ovarian cancer, and glioblastoma. In both studies, the authors demonstrated that synNotch-CAR T cells were better at controlling tumors than traditional CAR T cells and did not result in toxicity or damage to healthy tissue. These results suggest that synNotch-CAR T cells may be an effective treatment strategy for solid tumors. ....

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