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Lymphatic-specific intracellular modulation of receptor tyrosine kinase signaling improves lymphatic growth and function

Lymphatic-specific intracellular modulation of receptor tyrosine kinase signaling improves lymphatic growth and function
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United States , San Diego , Baden Wüberg , Leica Microsystems , Lecs Promocell , Millipore Burlingame , Sakura Finetek , Abcam Cambridge , Qiagen Hilden , Biosciences Franklin Lakes , Laboratory Animals , Henry Schein Animal Health , National Institutes Of Health , Light Sources Inc , Cell Signaling Technology Danvers , Committee At Memorial Sloan Kettering Cancer Center , Graphpad Prism Software , Vector Laboratories Inc , Sigma Aldrich , Affymetrix Inc , American Veterinary Medical Association , Cell Sciences , Jackson Laboratory , Institutional Animal Care , Use Committee , Memorial Sloan Kettering Cancer Center ,

Antitumor Potential of Miltefosine-Loaded Lipid Carriers

The ability of NLCs as a drug delivery system for enhanced pharmacokinetic, antitumor, and apoptotic effects, most importantly when loaded with HePC ....

Nordrhein Westfalen , United States , United Kingdom , Quaidi Azam University , South Korea , Duksan Ansan , Malvern Instruments Ltd , Riphah International University , National Institutes Of Health , World Health Organization , Vector Laboratories Inc , Shaanxi Yuantai Biological Technology Co Ltd , Quaidi Azam University Islamabad , Laboratory Poole , International Agency For Research On Cancer , Ethics Committee Of Quaidi Azam University , Korean Cell Bank Seoul , International Agency , Junn Terminal , New York , Creative Biomart , Korean Cell Bank , Ethics Committee , National Institutes , Polydispersity Index , Zeta Potential ,

[Full text] Paeoniflorin Sensitizes Breast Cancer Cells to Tamoxifen by Downregula

H) CCND1 expression in BC patients revealed by GEPIA website (
I) the β-catenin and GSK3β expression as well as the extent of GSK3β phosphorylation in MCF-7 and T47D parents and resistant cells. Data are displayed in the form of mean ± SD. All experiments were repeated at least three times. In panel (
B) two-way ANOVA along with Tukey’s multiple comparison was applied, while in panel (
D, E and
p 0.05,
p 0.01.
Abbreviations: miR, microRNA; FOXO1, forkhead box O1; CCND1, cyclin D1; SD, standard deviation; ANOVA, analysis of variance.
We predicted that FOXO1 could bind to the promoter sequence of CCND1 through the JASPAR website ( ....

United Kingdom , United States , Pae Downregulates , Franklin Lakes , Apollo Ribobio , Clark Bioscience , Paeoniflorin Pae , Shanghai Genepharma Co Ltd , Abcam Inc , Vector Laboratories Inc , Statistical Program For Social Sciences , Beyotime Biotechnology Co Ltd , Guangzhou Ribobio Co Ltd , Promega Corporation , Invitrogen Inc , Monmouth Junction , Cell Signaling Technologies , American Type Culture Collection , Cell Counting , Bio Rad Laboratories , Oligonucleotides Used , Enhanced Chemiluminescence Reagent Kit , Little Chalfont , Active Motif , Vector Laboratories , Statistical Program ,

Frontiers | Quantification of Huntington's Disease Related Markers in the R6/2 Mouse Model

2Department of Health Studies, FH Joanneum University of Applied Sciences, Graz, Austria
Huntington’s disease (HD) is caused by an expansion of CAG triplets in the huntingtin gene, leading to severe neuropathological changes that result in a devasting and lethal phenotype. Neurodegeneration in HD begins in the striatum and spreads to other brain regions such as cortex and hippocampus, causing motor and cognitive dysfunctions. To understand the signaling pathways involved in HD, animal models that mimic the human pathology are used. The R6/2 mouse as model of HD was already shown to present major neuropathological changes in the caudate putamen and other brain regions, but recently established biomarkers in HD patients were yet not analyzed in these mice. We therefore performed an in-depth analysis of R6/2 mice to establish new and highly translational readouts focusing on Ctip2 as biological marker for motor system-related neurons and translocator protein (TSPO) as a promisi ....

United States , Panreac Applichem Gmb , Zeiss Axiocam , Graphpad Software Inc , Vector Laboratories Inc , Accreditation Of Laboratory Animal Care , Association For Assessment , Western European , Jackson Laboratories , Raumordnung Austria , Pan Biotech , Thermo Scientific , Blocking Reagent , Vector Laboratories , Synaptic Systems , Panreac Applichem Gmbh , Sigma Aldrich , Novus Biologicals , Quantitative Image , Image Pro , Media Cybernetics , Supplementary Table , Supplementary Material , Laboratory Animal Care , Med Abstract , Crossref Full Text ,