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Frontiers | Significant Difference of Immune Cell Fractions and Their Correlations With Differential Expression Genes in Parkinson's Disease

Parkinson’s disease (PD) is the second most neurodegenerative disease in the world. T cell infiltration in the central nervous system (CNS) has provided insights that the peripheral immune cells participate in the pathogenesis of PD. However, the association between the peripheral immune system and CNS is remained to be elucidated. Here, we analyzed an incorporative substantial nigra expression data as well as another blood expression data using the CIBERSORT to obtain the 22 immune cells fraction and then explored the molecular function to identify the potential key immune cell types and genes of PD. We observed the proportions of naïve CD4 T cells, gamma delta T cells, resting NK cells, neutrophils in the blood, and regulatory T cells (Tregs) in the substantial nigra were significantly different between PD patients and healthy controls (HC). We identified p53-induced death domain protein 1 (PIDD1) as the hub gene of a Parkinson’s disease-related module. The set of neuron-spe ....

United States , J Neuroimmune Pharmacol , Felix Garza , Tregs Rosenkranz , Acta Neuropathol , Guangdong Province Key Laboratory Of Fermentation , National Natural Science Foundation Of China , Graphpad Software , Differential Gene Expression , Supplementary Table , Supplementary Figures , Enrichment Analysis , Kyoto Encyclopedia , Graphpad Prism , Supplementary Figure , National Natural Science Foundation , High Level Hospital Construction Project , Guangdong Province Key Laboratory , Enzyme Engineering , Supplementary Material , Med Abstract , Crossref Full Text , Meyer Zu Horste , Parkinson 39s Disease , Immune Cells , Substantia Nigra ,

SARS-CoV-2 vaccine efficacy is strongly correlated with antibody neutralization levels

All COVID-19 vaccines appear less effective when faced with variants such as Delta, according to a new medRxiv study. However, the researchers suggest that booster shots may help improve immunity and protect against symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. ....

United States , Jocelyn Solis Moreiraaug , Jocelyn Solis Moreira , Supplementary Table , Coronavirus Disease Covid 19 , Ars Cov 2 , N Vitro , Evere Acute Respiratory , Evere Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , துணை மேசை , ச்சனியான விட்ரோ ,