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Flagging potential molecular predictors of response to biological therapies in ulcerative colitis


Flagging potential molecular predictors of response to biological therapies in ulcerative colitis
Thousands of people around the world suffer from chronic bowel diseases. One such common disease is ulcerative colitis (UC), which causes inflammation and sores in the digestive tract of affected individuals. Interestingly, the symptoms of UC are caused by many of the body s natural defense biomolecules gone rogue! A few examples include abnormal elevation of tumor necrosis factor (TNF)-a and integrin levels. To treat UC, doctors prescribe several biologic therapies that act to bring down the elevated levels of these biomolecules.
While this seems like a straightforward strategy to alleviate UC, sometimes these biologic therapies don t work on a specific subset of patients, aptly called non-responders. Much to the dismay of clinicians and non-responders, these situations lead to unnecessary medication, wasteful expenses, and delay in starting alternatives. Studies place such n ....

United States , Ji Li , Emily Henderson , Union Medical College , Department Of Gastroenterology , Chinese Academy Of Medical Sciences , Chinese Medical , Chinese Academy , Medical Sciences , Peking Union Medical College , ஒன்றுபட்டது மாநிலங்களில் , ஜி லி , எமிலி ஹென்டர்சன் , தொழிற்சங்கம் மருத்துவ கல்லூரி , துறை ஆஃப் இரைப்பை குடல் , சீன கலைக்கழகம் ஆஃப் மருத்துவ அறிவியல் , சீன மருத்துவ , சீன கலைக்கழகம் , மருத்துவ அறிவியல் , பேகிங் தொழிற்சங்கம் மருத்துவ கல்லூரி ,

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Scientists atSt. JudeChildren’s Research Hospital are working with colleagues in China to develop better therapy for childhood acute lymphoblastic leukemia (ALL). Results from a large phase 3 noninferiority clinical trial definitively showed that vincristine and dexamethasone pulses can be eliminated in patients with low-risk disease. The findings were published today in
The
Lancet Oncology.
Adding the chemotherapy vincristine plus a steroid (originally prednisone, and later dexamethasone) as pulse therapy for childhood ALL has been part of standard care since the 1970s. This is despite their being associated with neuropsychological side effects, neuropathy and other late effects. However, to date studies about the need for prolonged treatment with pulse therapy have been inconclusive. ....

Hong Kong , Hua Jiang , University Of Hong Kong , Hong Kong General , Hui Jiang , Hui Zhang , Jing Chen , Jingyan Tang , Aiguo Liu , Ju Gao , Yingchi Zhang , Wenyu Yang , Changda Liang , Minghua Yang , Kaili Pan , Runming Jin , Yongjun Fang , Chunfu Li , Yiping Zhu , Lirong Sun , Junj Yang , Jiaoyang Cai , Jie Yu , Xuedong Wu , Xiaowen Zhai , Ningling Wang ,

International collaboration helps refine treatment for childhood leukemia

International collaboration helps refine treatment for childhood leukemia
prnewswire.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from prnewswire.com Daily Mail and Mail on Sunday newspapers.

Hong Kong , Hua Jiang , University Of Hong Kong , Hong Kong General , Hui Jiang , Hui Zhang , Jing Chen , Jingyan Tang , Aiguo Liu , Ju Gao , Yingchi Zhang , Wenyu Yang , Changda Liang , Minghua Yang , Kaili Pan , Runming Jin , Yongjun Fang , Chunfu Li , Yiping Zhu , Lirong Sun , Junj Yang , Jiaoyang Cai , Jie Yu , Xuedong Wu , Xiaowen Zhai , Ningling Wang ,