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Researchers call for trials of rapamycin to treat COVID-19

Researchers call for trials of rapamycin to treat COVID-19
Researchers in the United States, China, and the UK have called for immediate large-scale clinical trials of an antibiotic called rapamycin as a prophylactic and treatment approach to coronavirus disease 2019 (COVID-19) in older individuals.
Matt Kaeberlein from the University of Washington in Seattle and colleagues say that preclinical and clinical evidence already suggests that rapamycin and its derivatives (rapalogs) may delay or reverse the age-related decline in immune function that makes older individuals more susceptible to severe complications and death due to disease.
These drugs are inhibitors of the mammalian target of rapamycin (mTOR) protein that regulates the aging of eukaryotes. Inhibition of mTOR has already been shown to delay or reverse many age-related phenotypes, including declines in immune function. ....

United States , United Kingdom , Matt Kaeberlein , Sally Robertson , University Of Washington , Lancet Health Longevity , Corona Virus , Coronavirus Disease Covid 19 , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , சாலி ராபர்ட்சன் , பல்கலைக்கழகம் ஆஃப் வாஷிங்டன் , கொரோனா வைரஸ் ,

Decision-support tool may help clinicians to appropriately treat children with diarrhea

Decision-support tool may help clinicians to appropriately treat children with diarrhea
A decision-support tool that could be accessed via mobile devices may help clinicians in lower-resource settings avoid unnecessary antibiotic prescriptions for children with diarrhea, a study published today in
eLife shows.
The preliminary findings suggest that incorporating real-time environmental, epidemiologic, and clinical data into an easy-to-access, electronic tool could help clinicians appropriately treat children with diarrhea even when testing is not available. This could help avoid the overuse of antibiotics, which contributes to the emergence of drug-resistant bacteria.
Diarrhea is a common condition among children in low-resource settings. Antibiotics are often prescribed for it, despite the fact these medications will not help patients who have diarrhea caused by viruses. Helping clinicians determine if a case of diarrhea is likely caused by a virus or bacteria cou ....

Salt Lake City , United States , University Of Utah , Daniel Leung , Benjamin Brintz , Emily Henderson , University Of Utah Health , Division Of Epidemiology , Lead Author , Research Associate , Utah Health , Associate Professor , Internal Medicine , Infectious Disease , Adjunct Associate Professor , Health Care , உப்பு ஏரி நகரம் , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் உட்டா , டேனியல் லேஉங் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் உட்டா ஆரோக்கியம் , பிரிவு ஆஃப் தொற்றுநோய் , வழி நடத்து நூலாசிரியர் , ஆராய்ச்சி இணை , உட்டா ஆரோக்கியம் ,

Bacteria Have Been Seen Literally Changing Shape to Avoid Antibiotics

If you re a bacterium just trying to survive in a world filled with antibiotics you need some tricks up your sleeve. You can be poked by another bacterium to get some exciting new genetic material, or you can genetically mutate through the generati ....

Shiladitya Banerjee , University College London , Carnegie Mellon University , University Of Chicago , Nature Physics , Amp Quot , பல்கலைக்கழகம் கல்லூரி லண்டன் , கார்னகி மெலந் பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் சிகாகோ , இயற்கை இயற்பியல் , நுண்ணுயிர் எதிர்ப்பிகள் ,

Research highlights public health burden posed by livestock-associated MRSA

For Michigan State University's Felicia Wu, the surprise isn't that people who work with livestock are at higher risk of picking up antibiotic-resistant bacteria, but instead how much higher their risk levels are. ....

Emily Henderson , Society For Risk Analysis , Drug Administration , Department Of Food Science , Michigan State University Felicia Wu , Michigan State University , Hannah Distinguished Professor , Food Science , Human Nutrition , Corona Virus , Staphylococcus Aureus , எமிலி ஹென்டர்சன் , சமூகம் க்கு ஆபத்து பகுப்பாய்வு , துறை ஆஃப் உணவு அறிவியல் , மிச்சிகன் நிலை பல்கலைக்கழகம் ஃபெலிசியா வு , மிச்சிகன் நிலை பல்கலைக்கழகம் , ஹன்னா புகழ்பெற்ற ப்ரொஃபெஸர் , உணவு அறிவியல் , மனிதன் ஊட்டச்சத்து , கொரோனா வைரஸ் ,

Neonatal antibiotic treatment associated with reduced weight and height in boys

Neonatal antibiotic treatment associated with reduced weight and height in boys
Exposure to antibiotics in the first days of life is thought to affect various physiological aspects of neonatal development. A new study conducted in Turku, Finland, reveals that antibiotic treatment within 14 days of birth is associated with reduced weight and height in boys, but not girls, up to the age of six.
By contrast, the study showed significantly higher body mass index (BMI) in both boys and girls following antibiotic use after the neonatal period, and within the first six years of life.
The findings, published in the journal ....

Eteläuomen Läi , Omry Koren , Samuli Rautava , Emily Henderson , Nature Communications , University Of Helsinki , University Of Trento , Ilan University , Max Rubner Institute , Turku University Hospital , University Of Turku , Louzoun Lab At Bar , Associate Professor , Professor Samuli Rautava , Professor Omry Koren , Azrieli Faculty , Atara Uzan , Bar Ilan University , Professor Omry , Louzoun Lab , Body Mass Index , ஓம்ரி கோரன் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , பல்கலைக்கழகம் ஆஃப் ஹெல்சின்கி , பல்கலைக்கழகம் ஆஃப் ட்ரெண்டோ ,