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Study shows that single water molecule may cause antibiotic resistance

Study shows that single water molecule may cause antibiotic resistance
New high-resolution structures of the bacterial ribosome determined by researchers at the University of Illinois Chicago show that a single water molecule may be the cause -; and possible solution -; of antibiotic resistance.
The findings of the new UIC study are published in the journal Nature Chemical Biology.
Pathogenic germs become resistant to antibiotics when they develop the ability to defeat the drugs designed to kill them. Each year in the U.S., millions of people suffer from antibiotic-resistant infections, and thousands of people die as a result.
Developing new drugs is a key way the scientific community is trying to reduce the impact of antibiotic resistance. ....

United States , University Of Illinois At Chicago , Alexander Mankin , Yury Polikanov , Emily Henderson , Professor Of Pharmaceutical Sciences , University Of Illinois Chicago , Study Co , College Of Liberal Arts , College Of Pharmacy , Illinois Chicago , Nature Chemical , Study Co Author , Pharmaceutical Sciences , Liberal Arts , Antibiotic Resistance , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் இல் சிகாகோ , அலெக்சாண்டர் மாங்கின் , எமிலி ஹென்டர்சன் , ப்ரொஃபெஸர் ஆஃப் மருந்து அறிவியல் , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் சிகாகோ , படிப்பு இணை , கல்லூரி ஆஃப் தாராளவாத கலைகள் , கல்லூரி ஆஃப் மருந்தகம் , இல்லினாய்ஸ் சிகாகோ ,

Study improves understanding of the chemistry behind potent antibiotic synthesis

Study improves understanding of the chemistry behind potent antibiotic synthesis
Images of a protein involved in creating a potent antibiotic reveal the unusual first steps of the antibiotic s synthesis. The improved understanding of the chemistry behind this process, detailed in a new study led by Penn State chemists, could allow researchers to adapt this and similar compounds for use in human medicine.
The antibiotic thiostrepton is very potent against Gram-positive pathogens and can even target certain breast cancer cells in culture. While it has been used topically in veterinary medicine, so far it has been ineffective in humans because it is poorly absorbed. We studied the first steps in thiostrepton s biosynthesis in hopes of eventually being able to hijack certain processes and make analogs of the molecule that might have better medicinal properties. Importantly, this reaction is found in the biosynthesis of numerous other antibiotics, and so the work has the potent ....

Hayley Knox , Squire Booker , Emily Henderson , Howard Hughes Medical Institute , Penn State , Howard Hughes Medical , Breast Cancer , ஹேலி நாக்ஸ் , ஸ்கைர் புக்கர் , எமிலி ஹென்டர்சன் , ஹோவர்ட் ஹக்ஸ் மருத்துவ நிறுவனம் , பென் நிலை , ஹோவர்ட் ஹக்ஸ் மருத்துவ , மார்பக புற்றுநோய் ,

Inflammation may contribute to the persistence of C. diff infection, shows study

Inflammation may contribute to the persistence of C. diff infection, shows study
A new study from North Carolina State University shows that the inflammation caused by
Clostridioides difficile (
C. diff) infection gives the pathogen a two-fold advantage: by both creating an inhospitable environment for competing bacteria and providing nutrients that enable
C. diff to thrive.
C. diff is a bacterium that causes diarrhea, often with severe or even fatal consequences. As part of its growth cycle,
C. diff produces two toxins that cause inflammation and damage the lining of the gut.

C. diff thrives when other microbes in the gut are absent - which is why it is more prevalent following antibiotic therapy, says Casey Theriot, associate professor of infectious disease at NC State and corresponding author of the research. ....

Josh Fletcher , Casey Theriot , Emily Henderson , Carolina State University , North Carolina State University , Associate Professor , Infectious Disease , Study Corresponding Author , North Carolina State , C Diff , Amino Acid , Gene Expression , In Vitro , ஜோஷ் பிளெட்சர் , வழக்கு தேரியட் , எமிலி ஹென்டர்சன் , கரோலினா நிலை பல்கலைக்கழகம் , வடக்கு கரோலினா நிலை பல்கலைக்கழகம் , இணை ப்ரொஃபெஸர் , தொற்று நோய் , வடக்கு கரோலினா நிலை , அமினோ அமிலம் , கீந் வெளிப்பாடு , இல் விட்ரோ , வளர்சிதை மாற்றம் ,

Are antibiotic regimens for critical COVID-19 patients with bacterial superinfection unnecessarily high?

Are antibiotic regimens for critical COVID-19 patients with bacterial superinfection unnecessarily high?
Especially among the elderly, community-acquired pneumonia (CAP) is a major cause of death. The current coronavirus disease 2019 (COVID-19) pandemic has brought the focus on multiple common treatment practices for hospitalized COVID-19 patients, including empirical antibiotic therapy for suspected bacterial superinfection. However, a new study by researchers at Northwestern University Feinberg School of Medicine, USA, shows that this may be promoting an unnecessarily high incidence of antibiotic usage. The team’s findings are available on the
Existing empirical guidelines
Autopsy studies have shown that viral pneumonia often causes death partially due to secondary bacterial pneumonia. At the same time, there are no biomarkers capable of accurately identifying bacterial superinfection in patients who have severe CAP. Most earlier autopsy studies include mostly pat ....

United States , Liji Thomas , Infectious Diseases Society Of America , Northwestern University Feinberg School Of Medicine , American Thoracic Society , Northwestern University Feinberg School , Infectious Diseases Society , Narrow Antibiotic Treatment , Antimicrobial Resistance , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Infectious Diseases , ஒன்றுபட்டது மாநிலங்களில் , தொற்று நோய்கள் சமூகம் ஆஃப் அமெரிக்கா , வடமேற்கு பல்கலைக்கழகம் ஃபைன்பெர்க் பள்ளி ஆஃப் மருந்து , அமெரிக்கன் தொராசி சமூகம் , வடமேற்கு பல்கலைக்கழகம் ஃபைன்பெர்க் பள்ளி , தொற்று நோய்கள் சமூகம் , குறுகிய நுண்ணுயிர்க்கொல்லி சிகிச்சை , ஆண்டிமைக்ரோபியல் எதிர்ப்பு , கொரோனா வைரஸ் , தொற்று நோய்கள் , சர்வதேச பரவல் ,

Research uncovers strategy to revert antibiotic-resistance in dangerous superbugs

Research uncovers strategy to revert antibiotic-resistance in dangerous superbugs
Jan 18 2021
A major risk of being hospitalized is catching a bacterial infection. Hospitals, especially areas including intensive care units and surgical wards, are teeming with bacteria, some of which are resistant to antibiotics - they are infamously known as ‘superbugs’. Superbug infections are difficult and expensive to treat, and can often lead to dire consequences for the patient.
Now, new research published today in the prestigious journal Nature Microbiology has discovered how to revert antibiotic-resistance in one of the most dangerous superbugs. The strategy involves the use of bacteriophages (also known as ‘phages’). ....

Jeremy Barr , Fernando Gordillo Altamirano , Gordillo Altamirano , School Of Biological Sciences , Group Leader , Monash University School Of Biological Sciences , Center To Impact , Nature Microbiology , Monash University School , Biological Sciences , Intensive Care , ஜெர்மி பார் , பள்ளி ஆஃப் உயிரியல் அறிவியல் , குழு தலைவர் , மோனாஷ் பல்கலைக்கழகம் பள்ளி ஆஃப் உயிரியல் அறிவியல் , மையம் க்கு தாக்கம் , இயற்கை நுண்ணுயிரியல் , மோனாஷ் பல்கலைக்கழகம் பள்ளி , உயிரியல் அறிவியல் , தீவிர பராமரிப்பு ,