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Frontiers | Downregulation of CD45 Signaling in COVID-19 Patients Is Reversed by C24D, a Novel CD45 Targeting Peptide

CD45, the predominant transmembrane tyrosine phosphatase in leukocytes, is required for the efficient induction of T cell receptor signaling and activation. Various studies have demonstrated that viruses can interfere with the functions of CD45 and that patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are immune-suppressed. We recently reported that the CD45-intracellular signals in peripheral blood mononuclear cells (PBMCs) of triple negative breast cancer (TNBC) patients are inhibited. We also reported that C24D, an immune modulating therapeutic peptide, binds to CD45 on immune-suppressed cells and resets the functionality of the immune system via the CD45 signaling pathway. Given the similarity between the role of CD45 in viral immune suppression, reported by others, and our findings on TNBC, we hypothesized that the C24D peptide may have a similar “immune-resetting” effect. We tested this hypothesis by comparing the CD45 intracellular signaling in PBMC ....

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Immune response may be linked to AstraZeneca vaccine clot issue


Immune response may be linked to AstraZeneca vaccine clot issue
Four previously healthy individuals who got the AstraZeneca shot and developed life-threatening clots
Reuters
April 01, 2021
Vials labelled Astra Zeneca Covid-19 Coronavirus Vaccine and a syringe are seen in front of a displayed AstraZeneca logo, in this illustration photo taken March 14, 2021. PHOTO: REUTERS
The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for Covid-19, the illness caused by the virus.
Immune response may explain rare clots after AstraZeneca vaccine
Researchers may have found an explanation for the rare but serious blood clots reported among some people who received AstraZeneca s Covid-19 vaccine. They believe the phenomenon is similar to one that rarely occurs with a blood-thinning drug called heparin, called heparin-induced thrombocytopenia (HIT). In HIT, the drug triggers the imm ....

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As new cases drop, Israel's hospitals begin closing their COVID wards


As new cases drop, Israel s hospitals begin closing their COVID wards
With over 50% of Israelis fully vaccinated and infection rate down to single digits, some medical centers report no new virus patients have been admitted in past days; one hospital director says decrease much slower in Arab sector
Adir Yanko |
Published: 04.01.21 , 14:14
As new coronavirus cases continue to drop, some Israel s hospitals begin closing their dedicated COVID-19 wards, which have recently started to empty out.
Israel launched its high-paced vaccination drive in December and has so far fully vaccinated over half of the population, which prompted a decrease in coronavirus infection rate and basic reproduction number. ....

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