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Molecular Partners AG: Molecular Partners to Present Data from Localized Immune Agonist (MP0317), T-cell Engager, and Peptide-MHC Immunotherapy Programs at AACR Annual Meeting

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ZURICH-SCHLIEREN, SWITZERLAND / ACCESSWIRE /
March 10, 2021. Molecular Partners AG (SIX:MOLN), a clinical-stage biotech company that is developing a new class of custom-built protein drugs known as DARPin® therapeutics, today announced the upcoming presentation of four posters with data supporting three of the company s immunotherapy programs at the American Academy for Cancer Research (AACR) Virtual Annual Meeting running April 10-15, 2021.
The accepted research describes multiple aspects of validation for the unique mechanisms of these therapies in development for treating a wide range of tumor types.
Accepted abstract titles include:
MP0317 (targeting CD40 and FAP)
MP0317, a FAPxCD40 targeting multi-specific DARPin® therapeutic, drives immune activation and leads to macrophage repolarization in vitro and ex vivo ....

United States , Shai Biran , Prodrug Darpin , Seth Lewis , Thomas Schneckenburger , American Academy For Cancer Research , Company On Twitter At Molecularprtnrs , American Academy , Cancer Research , Virtual Annual Meeting , Molecular Partner , Molecular Partners , ஒன்றுபட்டது மாநிலங்களில் , ஷாய் பிரன் , சேதி லெவிஸ் , அமெரிக்கன் கலைக்கழகம் க்கு புற்றுநோய் ஆராய்ச்சி , அமெரிக்கன் கலைக்கழகம் , புற்றுநோய் ஆராய்ச்சி , மெய்நிகர் ஆண்டு சந்தித்தல் , மூலக்கூறு கூட்டாளர் , மூலக்கூறு கூட்டாளர்கள் , நோயெதிர்ப்பு சிகிச்சை ,

New biosensor measures extracellular hydrogen peroxide levels with nanometer-resolution

New biosensor measures extracellular hydrogen peroxide levels with nanometer-resolution
Several processes in the human body are regulated by biochemical reactions involving hydrogen peroxide (H
2O
2).
2O
2 is generally toxic because of its oxidant character. The latter means that it converts (oxidizes) biochemical molecules like proteins and DNA.
The oxidizing property of H
2O
2 is of potential therapeutic relevance for cancer, though: deliberately causing tumor cells to increase their H
2O
2 concentration would be a way to destroy them. In light of this, but also for monitoring pathologies associated with H
2O
2 overproduction, it is crucial to have a means to reliably quantify hydrogen peroxide concentrations in the extracellular environment. ....

Leonardo Puppulin , Emily Henderson , Nano Life Science Institute , Kanazawa University , Hydrogen Peroxide , Gold Nanoparticles , Raman Spectroscopy , எமிலி ஹென்டர்சன் , நானோ வாழ்க்கை அறிவியல் நிறுவனம் , கனசாவா பல்கலைக்கழகம் , ராமன் ஸ்பெக்ட்ரோஸ்கோபி ,

Parkinson's UK, University of Sheffield to develop new Parkinson's drug

Parkinson’s UK, University of Sheffield to develop new Parkinson’s drug
Parkinson s UK, the largest charitable funder of Parkinson s research in Europe, is investing up to £1.2 million into a pioneering one-year project in partnership with the University of Sheffield.
The project aims to refine a molecule that could be developed into a drug to protect dopamine-producing brain cells and slow down the progression of Parkinson s.
The funding boost comes via the charity s Parkinson s Virtual Biotech initiative, which is plugging the funding gap in drug development and fast-tracking the development of new treatments for people with Parkinson s.
Scientists at the University of Sheffield s Institute of Translational Neuroscience (SITraN) and Parkinson s UK have been developing molecules that can boost the function of the brain s energy-producing mitochondria, to halt Parkinson s - something no treatment can currently do. ....

United Kingdom , Heather Mortiboys , Arthur Roach , Emily Henderson , Institute Of Translational Neuroscience , Research At Parkinson United Kingdom , University Of Sheffield , Virtual Biotech , Translational Neuroscience , United Kingdom Senior Fellowship , United Kingdom Drug Discovery , Senior Lecturer , Cell Death , Drug Discovery , ஒன்றுபட்டது கிஂக்டம் , ஆர்தர் ரோச் , எமிலி ஹென்டர்சன் , நிறுவனம் ஆஃப் மொழிபெயர்ப்பு நரம்பியல் , ஆராய்ச்சி இல் பார்கின்சன் ஒன்றுபட்டது கிஂக்டம் , பல்கலைக்கழகம் ஆஃப் ஷெஃபீல்ட் , மெய்நிகர் பயோடெக் , மொழிபெயர்ப்பு நரம்பியல் , ஒன்றுபட்டது கிஂக்டம் மூத்தவர் கூட்டுறவு , ஒன்றுபட்டது கிஂக்டம் மருந்து கண்டுபிடிப்பு , மூத்தவர் விரிவுரையாளர் , செல் இறப்பு ,

Scientists develop RNA-based therapeutic strategy for Charcot-Marie Tooth disease

Scientists develop RNA-based therapeutic strategy for Charcot-Marie Tooth disease
Charcot-Marie Tooth disease is the most common hereditary neurological disease in the world. It affects the peripheral nerves and causes progressive paralysis of the legs and hands.
No treatment is currently available to fight this disease, which is due to the overexpression of a specific protein. Scientists from the CNRS, INSERM, the AP-HP and the Paris-Saclay and Paris universities have developed a therapy based on degrading the coding RNA for this protein in mice. Their work is patented and was published on 9 March 2021 in
Communications Biology.
In molecular biology, transcription is when a DNA molecule is copied to make an RNA molecule. This RNA molecule is then translated into a protein, which can perform different functions within the body s cells. When a specific protein called PMP22 is made twice as much as normal, it causes type 1A of genetic Charcot-Marie Tooth disease t ....

France General , Emily Henderson , Communications Biology , Marie Tooth , Charcot Marie Tooth , Molecular Biology , Neurological Disease , பிரான்ஸ் ஜநரல் , எமிலி ஹென்டர்சன் , தகவல்தொடர்புகள் உயிரியல் , மேரி பல் , கரி மேரி பல் , மூலக்கூறு உயிரியல் , நரம்பியல் நோய் ,

New technique helps image biological samples at the microscopic level

New technique helps image biological samples at the microscopic level
Researchers have developed a spectroscopic microscope to enable optical measurements of molecular conformations and orientations in biological samples. The novel measurement technique allows researchers to image biological samples at the microscopic level more quickly and accurately.
The new instrument is based on the discrete frequency infrared spectroscopic imaging technique developed by researchers at the Beckman Institute for Advanced Science and Technology at the University of Illinois Urbana-Champaign.
This project is about bringing the study of molecular chirality into the microscopic domain.
Rohit Bhargava, Professor, Bioengineering, Director, Cancer Center, Illinois
Molecular chirality refers to the spatial orientation of atoms in molecules or multimolecule assemblies. In biological systems, one molecule may elicit a cellular response, while its mirror image could be inactive or eve ....

United States , University Of Illinois , Beckman Institute , Kevin Yeh , Rohit Bhargava , Emily Henderson , Beckman Institute For Advanced Science , Structures Laboratory , Cancer Center , University Of Illinois Urbana Champaign , Advanced Science , Vibrational Circular Dichroism Measurements , Infrared Spectroscopic , Analytical Chemistry , Chemical Imaging , Yamuna Phal , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் , பெக்மேன் நிறுவனம் , கெவின் ஆமாம் , ரோஹித் பார்கவா , எமிலி ஹென்டர்சன் , கட்டமைப்புகள் ஆய்வகம் , புற்றுநோய் மையம் , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் ஊர்பன சாம்பியன் , பகுப்பாய்வு வேதியியல் ,