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Idorsia initiates the Phase 3 registration study with selatogrel for the treatment of acute myocardial infarction


and Chair of the Steering Committee
for SOS-AMI, commented:
P2Y
12 receptor antagonists have been used in the treatment of millions of patients globally, and their safety and efficacy profiles are well established. Despite the success of chronic treatment with this class and other effective interventions, patients are still suffering recurrent heart attacks. The idea for patients to self-inject early in the onset of symptoms is truly innovative. The subcutaneous route of administration could overcome the onset delay observed with oral compounds from the same class.
To be effective, any antithrombotic treatment for use at the onset of AMI symptoms should be rapidly absorbed and potent, acting quickly to inhibit thrombus formation at an early stage. Inhibition should be reversed after a few hours to avoid interfering with later patient management decisions. It must also have an appropriate safety profile for use prior to formal diagnosis of AMI. Selatogrel has the ....

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ON THE MOVE: Nomura Adds Sameer Jain; Mike Berry to Enfusion


Traders Magazine
-Nomura appointed former Barclays tech chief
Sameer Jain as CIO of its wholesale banking business, based in New York. Jain will have responsibility for Nomura’s Wholesale IT and Operations, ensuring that the firm’s technology architecture is aligned to support business requirements. Jain spent 13 years at Barclays, where he held senior technology roles including group chief technology officer and chief information officer. Before joining Barclays in 2006, he was director, global head of credit derivatives technology at UBS.
-Enfusion, a provider of native cloud-based investment management solutions and services, named
Mike Berry as Chief Operating Officer, and expanded its Client Services function with three new hires. Berry joins Enfusion from Bridgewater Associates where he helped transform the Back Office, Fund Tax, and Legal & Regulatory functions to adapt to an increasingly complex regulatory environment. Prior to Bridgewater, Mike w ....

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Fermanagh arts representatives recognised with awards in memory of Sir Ken Robinson


A LOCAL arts ambassador and a Fermanagh school have been awarded a share of the £20,000 Unlocking Creativity award fund, in memory of Sir Ken Robinson.
Noelle McAlinden, and St. Aidan’s High School, Derrylin are among the 11 inspirational individuals and groups recognised in the awards, which were announced by the Nerve Centre, Londonderry at a virtual awards ceremony hosted on their Facebook and YouTube channels on Friday, March 5.
Sir Ken Robinson led national and international projects on creative and cultural education across the world, unlocking and igniting the creative energy of many people and organisations, including pioneering work in Northern Ireland. ....

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Gibson Dunn | 2020 Year-End FCPA Update


Recovering from a relatively slow start to the year, due in no small part to the global pandemic, the U.S. Foreign Corrupt Practices Act (“FCPA”) Units of the U.S. Department of Justice (“DOJ”) and Securities and Exchange Commission (“SEC”) closed the year with a bang. With 32 combined FCPA enforcement actions, 51 total cases including ancillary enforcement, and a record-setting $2.78 billion in corporate fines and penalties (plus billions more collected by foreign regulators), 2020 marks another robust year in the annals of FCPA enforcement.
This client update provides an overview of the FCPA and other domestic and international anti-corruption enforcement, litigation, and policy developments from 2020, as well as the trends we see from this activity. We at Gibson Dunn are privileged to help our clients navigate these challenges daily and are honored again to have been ranked Number 1 in the ....

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For some strange reason, insurers no longer want to cover businesses in Portland


It’s going to get worse, too:
the repercussions of 7 months of madness here in Portland tacitly or explicitly supported by elected officials and much of the citizenry have only just begun. Anyone thinking about investing a cent here has another, entirely negative factor to ponder now https://t.co/WBC22sFknm
Get woke, go broke:
When a town gets woke, it goes broke!
Insurers balk at covering Portland businesses; brokers say downtown upheaval has made carriers wary https://t.co/yiBJQXf9tj
And here’s MSNBC’s Joe Scarborough on the story:
This is what happens when city and state leaders allow anarchists to run rampantInsurers balk at covering Portland businesses; brokers say downtown upheaval has made carriers wary https://t.co/Xh1dxabyvv ....

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