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The Toolmaker's Mind | Princeton Alumni Weekly

Photo: © John D. and Catherine T. MacArthur Foundation used with permission
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The Toolmaker’s Mind
Clifford Brangwynne marries engineering and biology in a quest to understand the inner workings of the cell
Photo: © John D. and Catherine T. MacArthur Foundation used with permission
By Carmen Drahl 07
The best way to learn how intensely Princeton bioengineer Clifford P. Brangwynne approaches life is to catch him playing hockey at Baker Rink. Before the COVID-19 pandemic, he had a standing noontime game. He’s played since childhood, mostly defense. At Baker, he might be fending off collaborator and friend Mikko Haataja, a professor of mechanical and aerospace engineering at Princeton and a formidable forward. “When you play intense sports, that’s the only thing that’s consciously on your mind,” Brangwynne says. With skates on, he gets in the zone. And when Cliff Brangwynne gets in the zone, there’s no stopping him. ....

Chapel Hill , New Jersey , United States , Mikko Haataja , Cliff Brangwynne , Amy Gladfelter , Junek Wu , Rohit Pappu , Lou Gehrig , Amy Strom , Amy Strom Brangwynne , Osamu Shimomura , Frances Arnold , Cliffordp Brangwynne , Department Of Defense , National Institutes Of Health , University Of North Carolina , Princeton Bioengineering Initiative , California Institute Of Technology , Princeton Department Of Biology , Washington University In St , Blavatnik National , Howard Hughes Medical Institute , Biological Engineering , California Institute , Washington University ,

NIH awards $3.1 million grant for Washington University, St. Jude ALS research | The Source

NIH awards $3.1 million grant for Washington University, St. Jude ALS research
Five-year grant to McKelvey School of Engineering’s Pappu and co-PI Mittag will support study of RNA-binding proteins
March 5, 2021
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Rohit Pappu, the Edwin H. Murty Professor of Engineering in the Department of Biomedical Engineering,
received funds to study RNA-binding proteins that are mutated in patients with familial forms of amyotrophic lateral sclerosis (ALS).
Scientists from Washington University in St. Louis and St. Jude Children’s Research Hospital have been awarded a five-year $3.1 million grant from the National Institute of Neurological Disorders and Stroke, an affiliate of the National Institutes of Health (NIH). ....

Rohit Pappu , Lou Gehrig , Charles Roberts , Tanja Mittag , Edwinh Murty , Jude Department Of Structural Biology , Jude Children Research Hospital , National Institutes Of Health , Department Of Biomedical Engineering , Princeton University , Cancer Center , Mckelvey School Of Engineering At Washington University , Research Collaborative , Research Collaborative On Membraneless Organelles , Washington University In St , National Institute Of Neurological Disorders , Research Collaboratives , Washington University , Jude Children , Research Hospital , National Institute , Neurological Disorders , National Institutes , Biomedical Engineering , Mckelvey School , Jude Department ,

NIH awards $3.1 million grant for Washington University, St. Jude ALS research

Rohit Pappu, the Edwin H. Murty Professor of Engineering in the Department of Biomedical Engineering,
received funds to study RNA-binding proteins that are mutated in patients with familial forms of amyotrophic lateral sclerosis (ALS).
Scientists from Washington University in St. Louis and St. Jude Children’s Research Hospital have been awarded a five-year $3.1 million grant from the National Institute of Neurological Disorders and Stroke, an affiliate of the National Institutes of Health (NIH).
Rohit Pappu, the Edwin H. Murty Professor of Engineering in the Department of Biomedical Engineering in the McKelvey School of Engineering at Washington University, and Tanja Mittag, of the St. Jude Department of Structural Biology, received the funds to study RNA-binding proteins that are mutated in patients with familial forms of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. ....

Rohit Pappu , Lou Gehrig , Charles Roberts , Tanja Mittag , Edwinh Murty , Jude Research Collaboratives , Jude Department Of Structural Biology , Jude Children Research Hospital , National Institutes Of Health , Department Of Biomedical Engineering , Princeton University , Jude Research Collaborative On Membraneless Organelles , Jude Research Collaborative , Jude Comprehensive Cancer Center , Mckelvey School Of Engineering At Washington University , Washington University In St , National Institute Of Neurological Disorders , Biomedical Engineering , Washington University , Jude Children , Research Hospital , National Institute , Neurological Disorders , National Institutes , Mckelvey School , Jude Department ,

Researchers uncover the physics behind formation of branching microtubules during cell division

As any cook knows, some liquids mix well with each other, but others do not. For example, when a tablespoon of vinegar is poured into water, a brief stir suffices to thoroughly combine the two liquids. ....

Bernardo Gouveia , Elizabethw Dixon , Emily Henderson , Rohit Pappu , Donaldr Dixon , Joshua Shaevitz , Sagar Setru , Sabine Petry , Princeton University , Aerospace Engineering , Lewis Sigler Institute For Integrative Genomics , Lewis Sigler Institute , Howard Stone , Washington University , Cell Division , Molecular Biology , பெர்னார்டோ கொஊவேய , எமிலி ஹென்டர்சன் , ரோஹித் பப்பு , ஸெபீந் பெட்ரி , ப்ரிந்ஸ்டந் பல்கலைக்கழகம் , விண்வெளி பொறியியல் , லெவிஸ் சிகிலேர் நிறுவனம் க்கு ஒருங்கிணைந்த மரபியல் , லெவிஸ் சிகிலேர் நிறுவனம் , ஹோவர்ட் ஸ்டோந் , வாஷிங்டன் பல்கலைக்கழகம் ,

Dewdrops on a spiderweb reveal the physics behind cell structures

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VIDEO: : Researchers in the laboratories of Princeton University scientists Joshua Shaevitz, Howard Stone, and Sabine Petry have discovered that surface tension drives the liquid-like protein TPX2 to form globules that.
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Credit: Video by the authors: Sagar U. Setru, Bernardo Gouveia, Raymundo Alfaro-Aco, Joshua W. Shaevitz, Howard A. Stone and Sabine Petry
As any cook knows, some liquids mix well with each other, but others do not. For example, when a tablespoon of vinegar is poured into water, a brief stir suffices to thoroughly combine the two liquids. However, a tablespoon of oil poured into water will coalesce into droplets that no amount of stirring can dissolve. The physics that governs the mixing of liquids is not limited to mixing bowls; it also affects the behavior of things inside cells. It s been known for several years that some proteins behave like liquids, and that some liquid-like proteins don t mix together. However, ....

Howarda Stone , Bernardo Gouveia , Elizabethw Dixon , Joshuaw Shaevitz , Raymundo Alfaro , Rohit Pappu , Donaldr Dixon , Sagaru Setru , Sagar Setru , Joshua Shaevitz , Sabine Petry , National Science Foundation Graduate Research Fellowship Program , Pew Scholars Program , National Institute On , Packard Foundation , National Human Genome Research Institute , Aerospace Engineering , Lewis Sigler Institute For Integrative Genomics , Lewis Sigler Institute , Howard Stone , Washington University , Raymundo Alfaro Aco , Nature Physics , Daisy Soros Fellowships , New Americans , National Science Foundation ,