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HKUMed discovers a novel mediator of liver fibrosis and its underlying mechanism that can be a new therapeutic target


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HKUMed discovers a novel mediator of liver fibrosis and its underlying mechanism that can be a new therapeutic target
HKUMed discovers a novel mediator of liver fibrosis and its underlying mechanism that can be a new therapeutic target. The research was led by Dr Ruby Hoo Lai-chong (second from left), Assistant Professor, Department of Pharmacology and Pharmacy, HKUMed and Co-investigator of State Key Laboratory of Pharmaceutical Biotechnology, HKU. Dr Wu Xiaoping (second from right), post-doctoral fellow, Department of Pharmacology and Pharmacy, HKUMed is the first author. Other research team members include: Ms Zong Jiuyu (left) and Ms Zhang Zixuan (right), postgraduate student, Department of Pharmacology and Pharmacy, HKUMed. ....

United States , Hong Kong , Li Jingjing , Zong Jiuyu , Zhang Zixuan , Wang Cunchuan , Ruby Hoo Lai Chong , Shu Lingling , Wu Xiaoping , Health Bureau , Key Laboratory Of Pharmaceutical Biotechnology , University Of Hong Kong Hkumed , Research Grants Council , Department Of Medicine , Technology Program , Collaborative Research Fund , Professor Of Department Pharmacology , Drug Administration , Department Of Pharmacology , Guangdong Pharmaceutical University , Sun Yat Sen University Cancer Center , Research Program , Professor Of The Department Pharmacology , Health Medical Research Fund , First Affiliated Hospital Of Jinan University , Assistant Professor ,

Beyond secretion of insulin,the novel function of β cell in regulating glucose homeostasis


In a new study published in
Journal of Extracellular Vesicles, Chen-Yu Zhang s group and Antonio Vidal-Puig s group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output.
Over 100 years after insulin was discovered, it was believed that pancreatic β cells only secreted a single hormone insulin. Pancreatic β cell-derived insulin regulates glucose homeostasis by binding with the insulin receptors located in the liver, skeletal muscle, adipose tissues and other peripheral organs. The discovery of insulin and its receptor was essential to understand the mechanisms controlling glucose homeostasis and the pathogenesis of type 2 diabetes defined by defective insulin secretion, signal transduction and insulin resistance. However, gluco ....

Jing Li , United Kingdom , Xiang Zhang , Junfeng Zhang , Antonio Vidal Puig , Dameng Li , Eunyoung Lee , Shibei Wang , Chen Yu Zhang , Xiaohong Jiang , Yuchen Liu , Xin Dai , Mingliang Zhang , Yujing Zhang , Weiping Jia , Century Excellent Talents In University , National Basic Research Program Of China , Institute Of Life Sciences , Key Laboratory Of Pharmaceutical Biotechnology , National Science Fund For Distinguished Young Scholars , University Of Cambridge , Program No , Drum Tower Hospital Center , Research Funds For The Central Universities , Natural Science Foundation Of Jiangsu Province , Ministry Of Education ,

Pancreatic β cell-derived exosomal miR-29 family enhances hepatic glucose output


In a new study published in
Journal of Extracellular Vesicles, Chen-Yu Zhang s group at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig s group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in response to high levels of free fatty acids (FFAs). Theses β cell-derived exosomal miR-29s regulate glucose homeostasis through their manipulations on glucose output in liver.
Previously, Chen-Yu Zhang s group identified extracellular miRNA as a new form of cell-to-cell communication. They are among the first that reported the selective secretion of miRNAs under different physiological or pathological states; also, the uptake and function of secreted miRNAs in recipient cells. In the past decade, intensive studies have revealed the role of extracellular miRNAs in a range of biological processes. Thus, as a newly-emerged secretory factor, more insightful studies are needed to further reveal its re ....

Jing Li , United Kingdom , Xiang Zhang , Junfeng Zhang , Antonio Vidal Puig , Dameng Li , Eunyoung Lee , Shibei Wang , Chen Yu Zhang , Xiaohong Jiang , Yuchen Liu , Xin Dai , Mingliang Zhang , Yujing Zhang , Weiping Jia , Century Excellent Talents In University , National Basic Research Program Of China , Institute Of Life Sciences , Key Laboratory Of Pharmaceutical Biotechnology , National Science Fund For Distinguished Young Scholars , University Of Cambridge , Program No , Drum Tower Hospital Center , Research Funds For The Central Universities , Natural Science Foundation Of Jiangsu Province , Ministry Of Education ,