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Spinal Fluid Detects Neurodegeneration, Alzheimer's in Living Patients

Spinal Fluid Detects Neurodegeneration, Alzheimer's in Living Patients
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Department Of Neurology At Penn Medicine , Frontotemporal Degeneration Center , Journal Of The Alzheimer Association , Perelman School Of Medicine , Swedish State Support For Clinical Research , Swedish Alzheimer Foundation , Swedish Research Council , European Union Joint Program For Neurodegenerative Disorders , University Of Pennsylvania , Alzheimer Drug Discovery Foundation , Alzheimer Association Research Fellowship , European Research Council , Perelman School , Swedish State Support , Clinical Research , European Union Joint Program , Neurodegenerative Disorders , Association Research Fellowship , இதழ் ஆஃப் தி முதுமறதி சங்கம் , பெரல்மேன் பள்ளி ஆஃப் மருந்து , ஸ்விட்ச் நிலை ஆதரவு க்கு மருத்துவ ஆராய்ச்சி , ஸ்விட்ச் முதுமறதி அடித்தளம் , ஸ்விட்ச் ஆராய்ச்சி சபை , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , முதுமறதி மருந்து கண்டுபிடிப்பு அடித்தளம் , ஐரோப்பிய ஆராய்ச்சி சபை ,

Aortic Stiffening Linked to Alzheimer's Biomarkers


Jun 1, 2021
Associations seen with many CSF measures, but not beta-amyloid
Aortic stiffening was associated with cerebrospinal fluid (CSF) markers of neurodegeneration and Alzheimer’s disease, a cross-sectional study found.
“Among our oldest participants, age 74 years and older, greater aortic stiffening is associated with in vivo biomarker evidence of neuroinflammation, tau phosphorylation, synaptic dysfunction, and neurodegeneration, but not amyloidosis,” wrote Angela Jefferson, PhD, of Vanderbilt University in Nashville, Tennessee, and co-authors in
“Central arterial stiffening may lead to cumulative cerebral microcirculatory damage and blood flow delivery to tissue, resulting in neuroinflammation and neurodegeneration in more advanced age,” the researchers continued. “Collectively, our results suggest arterial stiffness does not primarily affect brain health through amyloidosis but rather through concomitant pathways of injury, though findings mus ....

United States , North Carolina , United Kingdom , Wake Forest University , Vanderbilt University , Angela Jefferson , Paul Smyth , Timothy Hughes , Ihab Hajjar , National Institutes Of Health , Vanderbilt University In Nashville , United Kingdom Dementia Research Institute , Swedish Alzheimer Foundation , Swedish Research Council , Emory University In Atlanta , European Union Joint Program For Neurodegenerative Disorders , Alzheimer Association , Alzheimer Drug Discovery Foundation , Wake Forest University In Winston Salem , European Research Council , Vanderbilt Memory , Aging Project , Emory University , Contributing Writer , National Institutes , County Councils ,

Possible new PET tracer for early detection of Alzheimer's


Date Time
Possible new PET tracer for early detection of Alzheimer’s
New biomarkers for Alzheimer’s disease are a priority area for researchers seeking to learn more about the disease and find possible methods of early diagnosis. Researchers at Karolinska Institutet have now studied a new PET tracer that is an important diagnostic tool for the disease. The study on the tracer substance BU99008, which is published in Molecular Psychiatry, can play a key part in the early identification of signs of Alzheimer’s disease.
The binding of the PET-tracer BU99008 shows reactive astrogliosis in different parts of the brain of a deceased patient with Alzheimer’s disease. The colours show the extent of the binding, where green is low, yellow is medium, and red is high binding. Credit: Amit Kumar. ....

Uppsala Lan , United States , Karolinska Institutet , Inger Nennesmo , Martin Ingelsson , Agneta Nordberg , Amit Kumar , Niinaa Koistinen , Mona Lisa Malarte , Uppsala University , Department Of Neurobiology , Centre For Innovative Medicine , Indiana University School Of Medicine , Swedish Alzheimer Foundation , Tore Nilson Foundation , Foundation For Old Servants , Bertil Stohne Foundation , Swedish Dementia Association , Alzheimer Disease International , Swedish Research Council , Care Sciences , Swedish Brain Fund , Swedish Foundation For Strategic Research , Hans Osterman Medical Research Foundation , Molecular Psychiatry , Disease International ,