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The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation

The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

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Adult ADHD is linked to numerous physical conditions

Adult ADHD is linked to numerous physical conditions
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Karolinska Institutet , Henrik Larsson , Isabell Brikell , Catharinaa Hartman , Rietz Ebba , Evolan Pharma , Stephenv Faraone , Brianm Donofrio , Zheng Chang , Agnieszka Butwicka , Ralf Kuja Halkola , Paul Lichtenstein , Marica Leone , Stratneuro Karolinska Institutet , Samuele Cortese , European Union Horizon , Swedish Brain Foundation , Janssen Pharmaceutical Companies Of Johnson , Department Of Medical Epidemiology , National Institute Of Mental Health , Swedish National Patient Register , Swedish Research Council , Swedish Research Council For Health , Ebba Du Rietz , Medical Epidemiology , Swedish National Patient ,

Technique allows mapping of epigenetic information in single cells at scale

Date Time
Technique allows mapping of epigenetic information in single cells at scale
Decoding epigenomic information from individual cells from the mouse brain. Histones are attached to DNA as beads on a string, with different versions decorating the genome as “epigenetic stickers”, labelling which genes are turned on or off. The method single-cell CUT&Tag allows to examine tens of thousands of single cells at the same time to determine their histone profiles. Illustration by Amagoia Agirre.
Histones are tiny proteins that bind to DNA and hold information that can help turn on or off individual genes. Researchers at Karolinska Institutet have developed a technique that makes it possible to examine how different versions of histones bind to the genome in tens of thousands of individual cells simultanously. The technique was applied to the mouse brain and can be used to study epigenetics at a single-cell level in other complex tissues. The study is published in Natu ....

Amagoia Agirre , Mandy Meijer , Karolinska Institutet , Mukund Kabbe , Marek Bartosovic , European Union Horizon , Innovation Programme , Swedish Society For Medical Research , Karolinska Institute , Alice Wallenberg Foundation , Swedish Brain Foundation , Ming Wai Lau Centre For Reparative Medicine , Swedish Cancer Society , Swedish Research Council , Department Of Medical Biochemistry , Medical Biochemistry , Vinnova Seal , Excellence Marie Sklodowska Curie Actions , Swedish Society , Medical Research , Ming Wai Lau Centre , Reparative Medicine , Nature Biotechnology , European Union , Multiple Sclerosis , Research Council ,

Immune cells found in the brain are behind the depression experienced in inflammation

Credit: Thor Balkhed/Linköping University
Special immune cells found in the brain, microglia, play a key role in the processes that make you feel uneasy and depressed in correlation with inflammation. This is the conclusion of a study using mice carried out by researchers at Linköping University, Sweden. The results have been published in the scientific journal
Immunity, and suggest that microglial cells contribute to the negative mood experienced during several neurological diseases, and maybe also depression.
David Engblom s research group at Linköping University has spent many years looking at why inflammation in the body, such as a common cold or influenza, causes us to feel poorly and despondent, and why we feel like retiring into our shell. The activity of the immune system influences nerve cells in some way. However, normal cells of the immune system are not able to get into the brain: it is sensitive and must be protected. Instead, the brain has its own spe ....

Juan Hidalgo , Michael Fritz , Julia Levinsson , David Engblom , Maarit Jaarola , Johan Jakobsson , Marco Pignatelli , Carla Canal , Antonello Bonci , Hugoa Tejeda , Annam Klawonn , Silvia Castany , Markus Heilig , Department Of Biomedical , Swedish Research Council , Alice Wallenberg Foundation , Swedish Brain Foundation , Lars Hierta Memorial Foundation , Clinical Sciences , Fredrik Simil , ஜுவான் ஹிட்யால்கோ , மைக்கேல் ஃப்ரிட்ஸ் , மார்கோ பிக்நேடெலி , கார்லா கால்வாய் , மார்கஸ் ஹீலிக் , துறை ஆஃப் உயிர் மருத்துவ ,