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Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR tests


Batch testing for SARS-CoV-2
Frequent and accurate RT-PCR–based testing is essential for preventing and managing SARS-CoV-2 infection; however, active infection surveillance is still often limited by time or resources. Cleary
et al. demonstrate that considering population-level viral prevalence and individual viral loads allows for efficiency gains upon pooled testing with minimal loss of sensitivity, both theoretically and as validated in vitro using human swab and sputum samples. Barak
et al. show that pooled testing of 133,816 hospital-collected patient nasopharyngeal samples eliminated three quarters of testing reactions with only a minor reduction in sensitivity, demonstrating the efficacy of the approach in the field. Both studies suggest that considered pooling of individual samples before testing could reliably increase SARS-CoV-2 testing throughput. ....

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'The magic has started': Israel's vaccination results point a way out of the pandemic


‘The magic has started’: Israel’s vaccination results point a way out of the pandemic
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By Isabel Kershner and Carl Zimmer
February 7, 2021 — 12.52pm
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Jerusalem: In the most extensive real-world test so far, Israel has demonstrated that a robust coronavirus vaccination program can have a quick and powerful impact, showing the world a plausible way out of the pandemic.
Cases of COVID-19 and hospitalisations dropped dramatically among people who were vaccinated within just a few weeks, according to new studies in Israel, where a rapid vaccine rollout has made it a kind of test laboratory for the world. And early data suggests that the vaccines are working nearly as well in practice as they did in clinical trials. ....

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Israel's Vaccination Results Point a Way Out of Virus Pandemic


The results are all the more striking, experts said, because Israel is contending with a worrisome new variant of the coronavirus. The variant B.1.1.7 now accounts for up to 80 percent of the samples tested in Israel.
First identified in Britain in December, the variant has spread to 72 other countries and may be up to 50 percent more transmissible than other variants.
Israel leads the world in vaccinating its citizens. So far, more than a third of its population of more than nine million people has received a first dose of the Pfizer-BioNTech vaccine and nearly two million people have received a second dose. ....

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Who should get a vaccine first — the pensioner or the politician?


Who should get a vaccine first the pensioner or the politician?
Adam Taylor
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Israeli Prime Minister Benjamin Netanyahu greets the arrival of more than 100,000 of doses of the Pfizer coronavirus vaccine at Ben Gurion Airport near Tel Aviv on Dec. 9. (Abir Sultan/Pool/AP)
Now that the coronavirus vaccines are finally rolling out, one of the big debates is who should get them first. In Britain, which became the first country in the world to begin immunizations with a fully tested vaccine this week, 90-year-old retiree Margaret Keenan was the first person to receive a shot of the Pfizer/BioNTech vaccine on Tuesday. ....

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