May 11, 2021 at 6:00 am As vaccines to protect people from COVID-19 started becoming available in late 2020, the rhetoric of anti-vaccine groups intensified. Efforts to keep vaccines out of arms reinforce misinformation about the safety and effectiveness of the vaccines and spread disinformation — deliberately misleading people for political, ideological or other reasons. Vaccines have been met with suspicion and hostility for as long as they have existed. Current opposition to COVID-19 vaccines is just the latest chapter in this long story. The primary driver of vaccine hesitancy throughout history has not been money, selfishness or ignorance. “Vaccine hesitancy has less to do with misunderstanding the science and more to do with general mistrust of scientific institutions and government,” says Maya Goldenberg, a philosophy expert at the University of Guelph, Ontario, who studies the phenomenon. Historically, people harmed or oppressed by such institutions are the ones most likely to resist vaccines, adds Agnes Arnold-Forster, a medical historian at the University of Bristol in England.