sequence this variant and provide amazing information to the world so quickly. it's an amazing feat. the network for genomic surveillance in south africa, for example. what they show is that this is a virus now with at least 50 mutations, many of them spanning the previous variants of concern. alpha, beta, gamma and delta. at least 30 mutations in the spike protein alone that we know lead to immune invasion and escape and also increased replication so this is what makes it so concerning to us. >> what we hear again and again from health experts over the past 48 showers we don't know too much about this variant but people should get a vaccine or a booster if they have already had their first two shots, but here you're saying it's possible, even likely, that this could elude the vaccine, so how do you reconcile those two statements? >> yeah. look, i think, paula, you know, we have to go through a couple of weeks yet of uncertainty. there are three questions we