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A recent study conducted by a team of international scientists has revealed that the infectivity and pathogenicity of SARS-CoV-2 strongly depend on the genetic background of both the virus and the host.
A snake venom enzyme shows anti-SARS-CoV-2 activity in vitro As the coronavirus disease 2019 (COVID-19) pandemic continues to infect people worldwide, specific pharmaceutical interventions have been found to be few. As the logistics of mass vaccination are still being ironed out, most public health measures across the globe still largely involve non-pharmaceutical interventions (NPIs) such as physical distancing, hand and face hygiene, mask-wearing, isolation of infected people and tracing of contacts. Now, an interesting new study appearing on the bioRxiv* preprint server reports the viruci...
Nanobodies have potential to be developed into a treatment for COVID-19 Researchers at Karolinska Institutet in Sweden have developed, in collaboration with researchers in Germany and the U.S., new small antibodies, also known as nanobodies, which prevent the SARS-CoV-2 coronavirus from entering human cells. The research study, published in Science, shows that a combined nanobody had a particularly good effect - even if the virus mutated. According to the researchers, the nanobodies have the potential to be developed into a treatment for COVID-19. Specific proteins, spike proteins, on the su...
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One such strain is the South African 501.V2 and UK B1.1.7 strains, which have been isolated from many countries and seem to spread faster than the ancestral strain. A preprint that recently appeared on the bioRxiv server reports the computational structure of this strain and the possible effect of the mutations on infectivity and neutralization.
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Hypoxia signaling pathway could lead to COVID-19 treatments Researchers in Spain have demonstrated that studying the hypoxia signaling pathway could provide opportunities for treating coronavirus disease 2019 (COVID-19). The team conducted a study showing that hypoxic (oxygen-deficient) conditions reduced the expression of host cell receptors for the causative agent – severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hypoxic conditions reduced expression of angiotensin-converting enzyme 2 (ACE2) – the primary host cell receptor required for viral attachment and entry. They als...