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Researchers Just Looked at Neanderthal Poop to Understand Their Guts


Researchers Just Looked at Neanderthal Poop to Understand Their Guts
Photo: University of Bologna
Around 50,000 years ago, a bunch of Neanderthals made a home and a bathroom
out of what is now a rocky escarpment south of Valencia, Spain. Over the last few years, some of those paleo-poops, the oldest known to come from a human species, have been excavated and analyzed. Now, researchers have caught a glimpse of the ecosystems that existed in the guts of those early hominins, from a fecal deposit in the remnants of a fire pit on the site.
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Over 200 bacterial microorganisms were extracted from the ancient poop by an interdisciplinary team of archaeologists, microbiologists, and anthropologists. The researchers found a striking amount of consistency between the microbial residents of the Neanderthal gut and the sort of microbes that populate the guts of modern humans. That consistency shows many minuscule denizens of our insides are actually longstandi ....

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Novel effector biology research provides insights into devastating citrus greening disease


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IMAGE: Sec-delivered effector 1 (SDE1) induces reactive oxygen species (ROS) accumulation prior to yellowing symptoms in Arabidopsis thaliana leaves.
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Credit: Kelley J. Clark, Zhiqian Pang, Jessica Trinh, Nian Wang, and Wenbo Ma
Citrus greening disease, also known as Huanglongbing (HLB), is devastating to the citrus industry, causing unprecedented amounts of damage worldwide. There is no known cure. Since the disease s introduction to the United States in the early 2000s, research efforts have increased exponentially. However, there is still a lack of information about the molecular mechanism behind the disease.
Getting into the molecular details behind what contributes to citrus greening symptom development and disease progression is key to finding sustainable solutions to combat the pathogen, explained plant pathologist Wenbo Ma. We bring the community one step closer to understanding these mechanisms with our research. ....

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Inflamed environment is C. diff paradise


Clostridioides difficile (
C. diff) infection gives the pathogen a two-fold advantage: by both creating an inhospitable environment for competing bacteria and providing nutrients that enable
C. diff to thrive.
C. diff is a bacterium that causes diarrhea, often with severe or even fatal consequences. As part of its growth cycle,
C. diff produces two toxins which cause inflammation and damage the lining of the gut.

C. diff thrives when other microbes in the gut are absent - which is why it is more prevalent following antibiotic therapy, says Casey Theriot, associate professor of infectious disease at NC State and corresponding author of the research. But when colonizing the gut, ....

Stephanie Montgomery , Ruthj Parsons , Colleenm Pike , Michaelr Mclaren , Stephaniea Montgomery , Casey Theriot , Matthewh Foley , Joshuar Fletcher , Josh Fletcher , Alissaj Rivera , Caseym Theriot , Nature Communications , National Institutes Of Health , University Of Minnesota , University Of North Carolina Chapel Hill , Carolina State University , North Carolina State University , National Institutes , North Carolina , Chapel Hill , Lineberger Cancer Center , North Carolina Chapel Hill , Medicine Health , மாற்றாந்தாய் மாஂட்கம்ரீ , வழக்கு தேரியட் , ஜோஷ் பிளெட்சர் ,

Study in twins identifies fecal microbiome differences in food allergies


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A new study out of the University of Chicago and Stanford University on pairs of twins with and without food allergies has identified potential microbial players in this condition. The results were published on Jan. 19 in the
The study grew out of prior research in the Nagler laboratory at UChicago on the fecal microbiota in infants. By transplanting fecal microbes from healthy and food-allergic infants to germ-free mice (who do not possess a microbiome), investigators found that the healthy infant microbiota was protective against the development of food allergies.
In this study, we looked at a more diverse population across a large range of ages, said Cathryn Nagler, PhD, the Bunning Family Professor in the Pritzker School of Molecular Engineering, the Department of Pathology and the College at UChicago. By studying twin pairs, we had the benefit of examining genetically identical individuals who grew up in the same environment, which allowed us to begin ....

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