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Unlocking 'the shape of water' in mechanisms of antibiotic resistance

Credit: Jenny Fontaine/UIC
New high-resolution structures of the bacterial ribosome determined by researchers at the University of Illinois Chicago show that a single water molecule may be the cause and possible solution of antibiotic resistance.
The findings of the new UIC study are published in the journal
Nature Chemical Biology.
Pathogenic germs become resistant to antibiotics when they develop the ability to defeat the drugs designed to kill them. Each year in the U.S., millions of people suffer from antibiotic-resistant infections, and thousands of people die as a result.
Developing new drugs is a key way the scientific community is trying to reduce the impact of antibiotic resistance. ....

United States , Alexander Mankin , Egor Syroegin , Elena Aleksandrova , Steven Gregory , Gemma Atkinson , Yury Polikanov , Maxim Svetlov , Swedish Research Council , University Of Rhode Island , University Of Illinois Chicago , Umea University , National Institutes Of Health , College Of Liberal Arts , College Of Pharmacy , Illinois Chicago , Nature Chemical , Liberal Arts , National Institutes , United States Department , National Institute , Hatch Project , Cell Biology , Medicine Health , Pharmaceutical Science , Pharmaceutical Chemistry ,

Esophageal cancer patients show abundance of oral pathogens

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IMAGE: In the dental plaque samples, the prevalence of all bacteria, with the exception of F. nucleatum, was significantly higher in the test group versus the control group. The pie charts.
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Credit: Department of Periodontology,TMDU
Researchers led by Tokyo Medical and Dental University (TMDU) find that certain oral pathogens are more prevalent in esophageal cancer patients, and could be used as a novel diagnostic tool
Tokyo, Japan - It is increasingly clear that the trillions of bacteria that make themselves at home in and on the human body are more than just casual observers along for the ride. Gut bacteria in particular have been shown to have an enormous influence on human health, with studies suggesting they play a role in illnesses ranging from autoimmune disorders to anxiety and depression. ....

Satoshi Miyake , Tokyo Medical , Dental University , Infectious Bacteria , Dental Plaque , Risk Factors , Patients With Esophageal Cancer , Medicine Health , Dentistry Periodontal Disease , சதோஷி மியையாக்ய் , டோக்கியோ மருத்துவ , டெஂடல் பல்கலைக்கழகம் , டெஂடல் தகடு , ஆபத்து காரணிகள் , நோயாளிகள் உடன் உணவுக்குழாய் புற்றுநோய் , மருந்து ஆரோக்கியம் , பல் மருத்துவம் பெரியடாஂடல் நோய் ,

Researchers show Irish soil can offer more hope in fight against antibiotic resistance

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IMAGE: Researchers have discovered soil in the West Fermanagh scarplands contains several species of these antibiotic producing organisms.
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Credit: Traditional Medicine Group
Scientists who highlighted the bug-busting properties of bacteria in Northern Irish soil have made another exciting discovery in the quest to discover new antibiotics.
The Traditional Medicine Group, an international collaboration of scientists from Swansea University, Brazil and Northern Ireland, have discovered more antibiotic-producing species and believe they may even have identified new varieties of antibiotics with potentially life-saving consequences.
Antibiotic resistant superbugs could kill up to 1.3 million people in Europe by 2050 - the World Health Organisation (WHO) describes the problem as one of the biggest threats to global health, food security, and development today . ....

United States , Simms Adu , Paul Facey , Hamid Bakshi , Gerry Quinn , Swansea University Nada Alharbi , Traditional Medicine Group , Swansea University , Ulster University , World Health Organisation , Northern Irish , Northern Ireland , West Fermanagh , County Fermanagh , Nada Alharbi , Cell Biology , Ecology Environment , Geology Soil , Medicine Health , ஒன்றுபட்டது மாநிலங்களில் , பால் முகம் , ஹமிட் பக்ஷி , ஜெர்ரி க்வின் , பாரம்பரிய மருந்து குழு , ஸ்வான்சீ பல்கலைக்கழகம் , அல்ஸ்டர் பல்கலைக்கழகம் ,

Faeces and algorithms: Artificial Intelligence to map our intestinal bacteria

The intestines and their bacteria are sometimes called our second brain , but studying these bacteria in their natural environment is difficult. Now researchers from the University of Copenhagen have developed a method that uses artificial intelligence to map intestinal bacteria using faeces. The researchers thus hope to gain more knowledge of the role played by these bacteria in various diseases. ....

Simon Rasmussen , Protein Research , University Of Copenhagen , Novo Nordisk Foundation Center , Associate Professor Simon Rasmussen , Medicine Health , Immunology Allergies Asthma , Internal Medicine , Metabolism Metabolic Diseases , Nutrition Nutrients , சிமோன் ராஸ்மஸெந் , ப்ரோடீந் ஆராய்ச்சி , பல்கலைக்கழகம் ஆஃப் கோபெந்ஹேகந் , இணை ப்ரொஃபெஸர் சிமோன் ராஸ்மஸெந் , மருந்து ஆரோக்கியம் , நோயெதிர்ப்பு ஒவ்வாமை ஆஸ்துமா , உள் மருந்து , இரைப்பை குடல் , வளர்சிதை மாற்றம் வளர்சிதை மாற்ற நோய்கள் , ஊட்டச்சத்து ஊட்டச்சத்துக்கள் ,

The cancer microbiome reveals which bacteria live in tumors

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IMAGE: A diagram of the species of bacteria from an individual patient that are more likely to be found with tumor samples (blue) or normal tissue samples (yellow). The layout.
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Credit: Anders Dohlman, Duke University
DURHAM, N.C. Biomedical engineers at Duke University have devised an algorithm to remove contaminated microbial genetic information from The Cancer Genome Atlas (TCGA). With a clearer picture of the microbiota living in various organs in both healthy and cancerous states, researchers will now be able to find new biomarkers of disease and better understand how numerous cancers affect the human body. ....

Xiling Shen , Holly Dressman , Diana Arguijo Mendoza , Anders Dohlman , Iliyand Iliev , Stevenm Lipkin , Michael Gao , Andersb Dohlman , Microbiome Atlas , National Institutes Of Health , Defense Advanced Research Projects Agency , Duke University , Cancer Genome Atlas , Cell Host , Hawkins Family Associate Professor , Biomedical Engineering , Cancer Microbiome Atlas , National Institutes , Pan Cancer Comparative Analysis , Distinguish Tissue Resident Microbiota , Shengli Ding , Biomedical Environmental Chemical Engineering , Medicine Health , ஹோலி டிரஸ்மேன் , மைக்கேல் கொ , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் ,