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Characterizing different cell types in the upper gastrointestinal tract

Researchers identified and characterized rare cell types in the esophagus, stomach and upper part of the small intestine, using single cell RNA sequencing. They provide detailed gene expression analyses for all epithelial cells in these organs. Furthermore, they identified a rare cell type that is most likely responsible for the secretion of high volumes of water in humans, providing a link to gastrointestinal defects in patients with cystic fibrosis. ....

Georga Busslinger , Hans Clevers , Auke Bogte , Harry Begthel , Georg Busslinger , Molecular Genetics At Utrecht University , Hubrecht Institute , Cell Reports , Luteinizing Hormone , Pediatric Oncology , Molecular Genetics , Utrecht University , Cell Biology , Developmental Reproductive Biology , Molecular Biology , Internal Medicine , மூலக்கூறு ஜெநெடிக்ஸ் இல் அட்ரெக்ட் பல்கலைக்கழகம் , செல் அறிக்கைகள் , குழந்தை புற்றுநோயியல் , மூலக்கூறு ஜெநெடிக்ஸ் , அட்ரெக்ட் பல்கலைக்கழகம் , செல் உயிரியல் , வளர்ச்சி இனப்பெருக்கம் உயிரியல் , மூலக்கூறு உயிரியல் , உள் மருந்து , இரைப்பை குடல் ,

Unveiling the cause of onion center rot

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IMAGE: Pantaphos, which is produced by the plant pathogen Pantoea ananatis, is responsible for causing onion center rot.
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Credit: Alex Polidore
Since 1983, the bacteria Pantoea ananatis has been known to infect several important crops including onions, rice, and corn. It was unclear, however, what molecules were involved. A new study, published in
mBio, has identified one of the culprits: pantaphos. Intriguingly, the researchers have discovered that pantaphos can also act as an herbicide and it is toxic to glioblastoma cells, making it an exciting candidate for agricultural and biomedical applications.
Herbicide resistant weeds are an issue in agriculture, said William Metcalf (MMG leader), a professor of microbiology. Unfortunately, there hasn t been a new class of herbicide for over 30 years. If we can understand how pantaphos causes onion rot, we can solve a big problem. ....

Alexander Polidore , Scientists At Cornell University , Hallmark Lesions Of Onion Center Rot , National Institutes Of Health , William Metcalf , Cornell University , Phosphonate Natural Product Made , Hallmark Lesions , Ionion Center , National Institutes , Fertilizers Pest Management , Food Science , Plant Sciences , Molecular Biology , அலெக்சாண்டர் போழிதோரெ , விஞ்ஞானிகள் இல் கார்னெல் பல்கலைக்கழகம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , வில்லியம் மெட்‌க்யாஃப் , கார்னெல் பல்கலைக்கழகம் , வெங்காயம் மையம் , தேசிய நிறுவனங்கள் , உரங்கள் பூச்சி மேலாண்மை , உணவு அறிவியல் , ஆலை அறிவியல் , உயிர் வேதியியல் , மூலக்கூறு உயிரியல் ,

Gene discovery may help peaches tolerate climate stress

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IMAGE: A behmi tree (Prunus mira), which is a wild relative of the domesticated peach, grows in its native habitat next to a glacier on the Tibetan Plateau.
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Credit: Image credit: Yong Li, from Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences
ITHACA, N.Y. A Boyce Thompson Institute-led team has identified genes enabling peaches and their wild relatives to tolerate stressful conditions findings that could help the domesticated peach adapt to climate change.
The study, co-led by Boyce Thompson Institute (BTI) faculty member Zhangjun Fei, examined the genomes of peach s wild relatives and landraces varieties that have adapted over a long time to specific local conditions from seven regions in China. They identified genes responsible for peach s tolerance to multiple environmental factors, including cold, drought and ultraviolet (UV-B) radiation levels at high altitudes. ....

Comunidad Autonoma De Cataluna , Tibetan Plateau , China General , Zhangjun Fei , Lirong Wang , Institute Of Agrifood Research , Us Department Of Agriculture , Huazhong Agricultural University , Boyce Thompson Institute , Genome Research , National Peach Germplasm Repository Of China , Chinese Academy Of Agricultural Sciences , Cornell University School Of Integrative Plant Science , Boyce Thompson Institute Led , Cornell University , Integrative Plant , Chinese Academy , Agricultural Sciences , Agrifood Research , National Peach Germplasm Repository , Agricultural Production Economics , Ecology Environment , Plant Sciences , Earth Science , Climate Change , காமுனிடட தன்னாட்சி டி கடலுள் ,

Nanoenzymes designed with a unique combination of structure and functions

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IMAGE: A) Spatial organisation of the catalytic biostructures. B) and C) Detail of the two types of amino acids and their interactions.
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Credit: IBB-UAB
Researchers at the UAB have designed minimalist biostructures that imitate natural enzymes, capable of carrying out two differentiated and reversibly regulated activities thanks to a unique combination of structural and functional properties. The strategy used opens the door to the creation of intelligent nanomaterials with tailor-made combinations of catalytic functions.
There is an increasing interest in synthetic systems that can execute bioinspired chemical reactions without requiring the complex structures that characterise enzymes in their components. One of the most explored approaches is the self-assembly of peptides - molecules smaller than proteins - due to their biocompatibility and how their structural and functional properties can be controlled. ....

Comunidad Autonoma De Cataluna , Mariona Sodupe , Francesc Teixidor , Francesca Peccati , Luis Rodr , Miquel Nuez Mart , Susanna Navarro , Centre For Cooperative Research In Biosciences , Institute Of Biotechnology , Institute Of Materials Science Barcelona , Universitat Aut , Salvador Ventura , Protein Folding , Conformational Diseases , Molecular Biology , Materials Science , Cooperative Research , Biomedical Environmental Chemical Engineering , Nanotechnology Micromachines , காமுனிடட தன்னாட்சி டி கடலுள் , மைக்கேல் நியூஸ் மார்ட் , சுசன்னா நேவாரு , மையம் க்கு கூட்டுறவு ஆராய்ச்சி இல் உயிர் அறிவியல் , நிறுவனம் ஆஃப் உயிரி தொழில்நுட்பவியல் , நிறுவனம் ஆஃப் பொருட்கள் அறிவியல் பார்சிலோனா , சால்வடார் வென்ச்சுரா ,

Tracing malaria's ecology using blood samples from birds

Malaria is the deadliest pathogen in human history, and by studying the strains of malaria that birds carry, scientists might be able to help prevent the disease in humans. Researchers analyzed blood samples of more than 1,000 species of birds from the Andes looking for malaria; they found that the strains of malaria present in a local area don t always neatly align with the types of birds living there. ....

University Of Chicago , United States , John Bates , Shannon Hackett , Heather Skeen , University Of New Mexico Christopher Witt , Field Museum , Cornell University Sabrina Mcnew , Cornell University , Sabrina Mcnew , New Mexico , Andes Mountains , Peruvian Andes , Shane Dubay , Ecology Environment , Population Biology , Zoology Veterinary Science , பல்கலைக்கழகம் ஆஃப் சிகாகோ , ஒன்றுபட்டது மாநிலங்களில் , ஜான் பேட்ஸ் , ஶ்யாநந் ஹேக்கெட் , ஹீத்தர் ஸ்கீன் , பல்கலைக்கழகம் ஆஃப் புதியது மெக்ஸிகோ கிறிஸ்டோபர் விட் , புலம் அருங்காட்சியகம் , கார்னெல் பல்கலைக்கழகம் சப்ரினா மிக்னேவ் , கார்னெல் பல்கலைக்கழகம் ,