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Intensified screening for SARS-CoV-2 in 18 emergency departments in the Paris metropolitan area, France (DEPIST-COVID): A cluster-randomized, two-period, crossover trial

Judith Leblanc and co-workers report a cluster-randomized trial evaluating intensive screening for SARS-CoV-2 infection in emergency departments. ....

France General , Îe De France , North Carolina , United States , Renaud Piarroux , Fatiha Djennaoui , Mohamed Hamidouche , Sonia Larid , Infectieuses Emergentes , Martine Piarroux , National Research Priority , French Ministry Of Health , National Orientation Committee For Therapeutic Trials , Committee For Patient Protection , Clinical Research Center Paris , Ablative Solutions , Informatics Commission , Clinical Research Unit Paris , Rr Core Team , National Freedom , Foundation For Statistical Computing , Qiagen Inc , French Ministry Of Higher Education , Appendixc Table Emergency Department , Ethical Committee Of Assistance Publique , Emergency Department ,

Genetic risk converges on regulatory networks mediating early type 2 diabetes

Type 2 diabetes mellitus (T2D), a major cause of worldwide morbidity and mortality, is characterized by dysfunction of insulin-producing pancreatic islet β cells1,2. T2D genome-wide association studies (GWAS) have identified hundreds of signals in non-coding and β cell regulatory genomic regions, but deciphering their biological mechanisms remains challenging3–5. Here, to identify early disease-driving events, we performed traditional and multiplexed pancreatic tissue imaging, sorted-islet cell transcriptomics and islet functional analysis of early-stage T2D and control donors. By integrating diverse modalities, we show that early-stage T2D is characterized by β cell-intrinsic defects that can be proportioned into gene regulatory modules with enrichment in signals of genetic risk. After identifying the β cell hub gene and transcription factor RFX6 within one such module, we demonstrated multiple layers of genetic risk that converge on an RFX6 ....

Robertc Turner , Arrojoe Drigo , Foundation For Statistical Computing , Human Pancreas Analysis Program , Islet Distribution Program , International Diabetes Federation Atlas , Rr Core Team , Haplotype Reference Consortium , Human Pancreas Analysis , Cell Metab , Integrated Islet Distribution Program , Applied Longitudinal Analysis , Gene Ontology , Acids Res , Cell Proteomics , Genome Biol , Statistical Computing , Kingdom Biobank ,

Burden of diarrhea and antibiotic use among children in low-resource settings preventable by Shigella vaccination: A simulation study

Leveraging data from 1715 children in the MAL-ED birth cohort study, Stephanie A Brennhofer and colleagues model the expected reduction in diarrhea episodes, antibiotic use, and bystander pathogen exposure to antibiotics through the administration of Shigella vaccines. ....

Monte Carlo , Nepal General , United States , Tamil Nadu , Minas Gerais , South Africa , Naushero Feroze , National Institute For Medical Research , Health Ministry , Christian Medical College , Fogarty International Center , Emory University Atlanta , Melinda Gates Foundation , Thermo Fisher , National Ethical Research Committee , Indian Council Of Medical Research India , Department Of Health , Johns Hopkins University , Tribhuvan University , Ethics Committee , Programme On Immunization , University Of Venda , Consequences For Child Health , Committee For Ethics , University Of Virginia School Medicine Charlottesville , Aga Khan University Pakistan ,

SciELO - Brasil - Benthic Macroinvertebrates Associated with Riparian Habitat Structural Diversity in an Eastern Amazon Stream Urbanization Gradient Benthic Macroinvertebrates Associated with Riparian Habitat Structural Diversity in an Eastern Amazon Stream Urbanization Gradient

SciELO - Brasil - Benthic Macroinvertebrates Associated with Riparian Habitat Structural Diversity in an Eastern Amazon Stream Urbanization Gradient Benthic Macroinvertebrates Associated with Riparian Habitat Structural Diversity in an Eastern Amazon Stream Urbanization Gradient
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Estado De Mato Grosso , Minas Gerais , Santa Catarina , United Kingdom , Rio De Janeiro , Estado Do Rio , United States , Rio Grande , Rio Grande Do Sul , Alto Uruguai , Ponta Grossa , Grand Duchy Of Luxembourg , Hydropsychidae Trichoptera , Perspectiva Erechim , Elmidae Coleoptera , Kaufmannv Caracteriza , Oecologia Australis , Felskif Avalia , Guillaume Blanchet , Nordeste Paraense , Exatase Naturais , Apodi Mossor , Internationalen Verein Limnologie , Acta Amazonica , Das Pedras , Poletoc Introdu ,

Effect of breathwork on stress and mental health: A meta-analysis of randomised-controlled trials

Deliberate control of the breath (breathwork) has recently received an unprecedented surge in public interest and breathing techniques have therapeutic potential to improve mental health. Our meta-analysis primarily aimed to evaluate the efficacy of breathwork through examining whether, and to what extent, breathwork interventions were associated with lower levels of self-reported/subjective stress compared to non-breathwork controls. We searched PsycInfo, PubMed, ProQuest, Scopus, Web of Science, ClinicalTrials.gov and ISRCTN up to February 2022, initially identifying 1325 results. The primary outcome self-reported/subjective stress included 12 randomised-controlled trials (k = 12) with a total of 785 adult participants. Most studies were deemed as being at moderate risk of bias. The random-effects analysis yielded a significant small-to-medium mean effect size, g = − 0.35 [95% CI − 0.55, − 0.14], z = 3.3 ....

New York , United States , United Kingdom , Republic Of , Indianj Palliat , Sudarshan Kriya , Erol Ursavas , Paul Joseph , Rd Claude Bernard , Cleve Clin , Rajendra Acharya , Robert Wood Johnson Foundation , World Health Organisation , Development Of The Perceived Stress Questionnaire , We Need To Talk Campaign , Nutrients Yoga In Mental Health Care , University Of Western Ontario , Harvard School Of Public Health , Ww Norton Company , Pandemic City University Of New York , Rr Core Team , Games Health , Anxiety Disorders Guilford , Foundation For Statistical Computing , National Health Service , A Randomized Controlled Trial Duke University ,