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Deep learning-based splice-AI can help predict the onset of Alzheimer's disease Korea Brain Research Institute (KBRI, President Suh Pann-ghill) announced that the research team led by Dr. Jae-Yeol Joo discovered new cryptic splice variants and SNVs in PLCg1 gene of AD-specific models for the first time using Splice-AI. This research outcome was published in PNAS, a world-renowned academic journal. Prediction of Alzheimer's Disease-Specific phospholipase c gamma-1 SNV by Deep Learning-Based Approach for High-Throughput Screening Alternative splicing variant regulates gene expression and influ...

Retroviruses invading the koala germline contribute to high cancer rates Koalas are facing multiple environmental and health issues which threaten their survival. Along with habitat loss - accelerated by last year’s devastating bush fires – domestic dog attacks and road accidents, they suffer from deadly chlamydial infections and extremely high frequency of cancer. An international team of scientists led by the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW) now demonstrate that a retrovirus invading the koala germline explains the high frequency of koala cancer. The results...

D, E) CTSG overexpression reduced the migration and invasion ability of OSCC cell lines. NC stands for negative control, while CTSG-OE represents CTSG overexpression. Significant differences were supposed at * P 0.05; ** Discussion Owing to the high recurrence rate and unsatisfied prognosis, OSCC poses a great challenge to modern healthcare. Recently, studies have demonstrated that the immune system was associated with OSCC initiation and progression. 7 Therefore, it might be helpful to identify effective biomarkers of OSCC through exploring the role of whole IRGs by integrated bioinformatic...

Huntington's disease is caused by a mutation in the Huntingtin gene (HTT), which appears in adults and features motor, cognitive and psychiatric alterations.

Polycomb complexes found to be essential for proper skin development Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene expression patterns, are essential for proper skin development, according to a paper published in Genes & Development on February 18. This latest discovery could improve development of future stem cell therapies to generate "skin on a dish" to transplant into burn victims and patients with skin-blistering disorders. Polycomb complexes are groups of proteins that maintain the gene-expression patterns during early developmen...