Live Breaking News & Updates on Genetic epidemiology

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This is the healthiest time to eat breakfast, according to Tim Spector

Tim Spector, founder of the Zoe nutrition programme, has shared his advice

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Eat nuts and seeds to fight off disease: Healthy snacks should be added to 5-a-day guidance to boost nation's health, report suggests

Studies have increasingly linked a daily handful of nuts and seeds to everything from lower chances of heart disease to cancer.

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Why I Changed My Mind About Vitamin D

Everyone loves D, the sunshine vitamin. Doctors, patients and the media have been enamored with vitamin D supplements for decades.

Finland , London , City-of , United-kingdom , United-states , Australia , Britons , Australians , Americans , Tim-spector , King-college-london , D-health-guage

Ludwig Backs Seven Early-Career Scientists at AACR Meeting

Ludwig Backs Seven Early-Career Scientists at AACR Meeting
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Study Finds ALL Genetic Variant That Indicates Why Hispanic, Pediatric Patients Are Likely to Develop Disease

Pediatric patients with the variant were approximately 1.44 times more likely develop ALL compared with children who do not have the variant.

Charleston-chiang , Leukemia-lymphoma-society , Keck-school-of-medicine , Norris-comprehensive-cancer-center , Keck-school , Southern-california , Hispanic-white , Genetic-epidemiology , East-asian , Adam-de-smith , Comprehensive-cancer-center

Unraveling Genetic Variant's Role in Childhood Leukemia Risk

The IKZF1 gene variant sheds light on the increased risk of acute lymphoblastic leukemia in Hispanic/Latino children.

California , United-states , Boston , Massachusetts , America , American , Charleston-chiang , Vijay-sankaran , Keck-school-of-medicine , Leukemia-lymphoma-society , Blood-disorders-center , Harvard-medical-school

Researchers find genetic variant contributing to disparities in childhood leukemia risk

Researchers find genetic variant contributing to disparities in childhood leukemia risk
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Study reveals genetic variant linked to increased risk of leukemia in Hispanic/Latino children

Acute lymphoblastic leukemia (ALL), the most common childhood cancer, disproportionately affects children of Hispanic/Latino origin in the United States.

San-francisco , California , United-states , Boston , Massachusetts , China , Stanford-university , Dana-farber-cancer-institute , Berkeley , Jun-yang , Jiangxi , Guangzhou

USC researchers find genetic variant contribu

<p style="text-align:start">Children of Hispanic/Latino origin are 30-40% more likely to get Acute lymphoblastic leukemia (ALL) than non-Hispanic white children. However, the exact genetic basis and cause of that increased risk are unknown. Now researchers have revealed a key genetic variant contributing towards the increased risk, as well as details about the biological basis of ALL. The research team focused on the <em>IKZF1 </em>gene, known to relate to ALL but never before linked with ethnic risk disparities. Using genetic fine-mapping analysis, they independently analyzed each position along the gene—known as a single nucleotide polymorphism (SNP)—to determine whether having a certain variant increased ALL risk. They found three independent SNPs linked to higher ALL incidence, one of which was present in about 30% of people of Hispanic/Latino origin in the U.S. and less than 1%  of people of primarily European origin. Although overall risk for the disease is low across all racial/ethnic groups, children with that gene variant, located at SNP rs76880433, were 1.44 times as likely to develop ALL as children without the variant. They also found that the risk variant reduced chromatin accessibility, preventing <em>IKZF1 </em>proteins from being fully expressed. In experiments with stem cells, the team found that “knocking out” the <em>IKZF1 </em>gene caused B-cell development to stall in its early stages.</p>

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USC researchers find genetic variant contribu

USC researchers find genetic variant contribu
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