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Major antioxidant in green tea may increase levels of natural anti-cancer protein


Major antioxidant in green tea may increase levels of natural anti-cancer protein
An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the guardian of the genome for its ability to repair DNA damage or destroy cancerous cells. Published today in
Nature Communications, a study of the direct interaction between p53 and the green tea compound, epigallocatechin gallate (EGCG), points to a new target for cancer drug discovery.
Both p53 and EGCG molecules are extremely interesting. Mutations in p53 are found in over 50% of human cancer, while EGCG is the major anti-oxidant in green tea, a popular beverage worldwide. Now we find that there is a previously unknown, direct interaction between the two, which points to a new path for developing anti-cancer drugs. Our work helps to explain how EGCG is able to boost p53 s anti-cancer activity, opening the door to developing drugs with EGCG-like compounds. ....

Jing Zhao , Lauren Gandy , Chunyu Wang , Weihua Jin , Emily Henderson , Xinyue Liu , Yuanyuan Xiao , Lufeng Yan , Alan Blaney , Nature Communications , Merck Research Laboratories , National Institutes Of Health , Rensselaer Polytechnic Institute , Rensselaer Center , China Agricultural University , Professor Of Biological Sciences , University Of Massachusetts , University Of New York At Binghamton , York University , Corresponding Author , Biological Sciences , Rensselaer Polytechnic , Interdisciplinary Studies , Intrinsically Disorderedn Terminal Domain , National Institutes , Upstate Medical ,

New tool enables study of SARS-CoV-2 mutant spectrum by ultrasequencing


New tool enables study of SARS-CoV-2 mutant spectrum by ultrasequencing
SARS-CoV-2 genome is three times larger than influenza genome. Both consist of NRA molecules that mutate when replicate. It is essential to know its mutant spectrum, in other words, its fingerprints , to achieve an appropriate treatment that reduces its infectivity -the capacity of pathogens to invade organisms and cause infections-, since its composition of variants could determine how infection would develop in each patient.
Researchers of the University of Malaga (UMA) will be able to examine the depth of these spectra by genetic ultrasequencing techniques thanks to the innovative system they have designed: QuasiFlow , a tool that enables the analysis of variants present in each patient individually. ....

Spain General , Gonzalo Claros , Miguel Hern , Pedro Seoane , Emily Henderson , Isabel Viciana , Enrique Viguera , Gregorio Fern , Diego Lozano , Department Of Cellular Biology , University Of Elche , Centre For Molecular Biology Severo Ochoa , Researchers Of The University Malaga , Spanish National Research Council , Fund Of The Government Andalusia , Professor Ana Grande , Cellular Biology , Dana Grande , Virgen De La Victoria University Hospital , Malaga Jes , Ugo Bastolla , Molecular Biology , Corona Virus , Sars Cov 2 , ஸ்பெயின் ஜநரல் , கோன்சலோ கிளாரோஸ் ,