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A brain enzyme plays an important role in waking up neural stem cells

A brain enzyme plays an important role in waking up neural stem cells
Researchers studying an enzyme in fruit fly larvae have found that it plays an important role in waking up brain stem cells from their dormant quiescent state, enabling them to proliferate and generate new neurons. Published in the journal EMBO Reports, the study by Duke-NUS Medical School, Singapore, could help clarify how some neurodevelopmental disorders such as autism and microcephaly occur.
Quiescent neural stem cells in the fruit fly larval brainPr-set7 is an enzyme involved in maintaining genome stability, DNA repair and cell cycle regulation, as well as turning various genes on or off. This protein, which goes by a few different names, has remained largely unchanged as species have evolved. Professor Wang Hongyan, a professor and deputy director at Duke-NUS Neuroscience and Behavioural Disorders Programme, and her colleagues set out to understand the protein s function during brain development ....

Wang Hongyan , Patrick Casey , Emily Henderson , Dean For Research At , Behavioural Disorders Programme , Senior Vice Dean , Professor Wang , Neural Stem Cells , Stem Cells , Medical School , பேட்ரிக் வழக்கு , எமிலி ஹென்டர்சன் , டீன் க்கு ஆராய்ச்சி இல் , நடத்தை கோளாறுகள் ப்ரோக்ராம் , மூத்தவர் துணை டீன் , ப்ரொஃபெஸர் வாங் , நரம்பியல் தண்டு செல்கள் , தண்டு செல்கள் , மன இறுக்கம் , மருத்துவ பள்ளி ,

Scientists publish new analysis of most diverse genetic data set

Scientists publish new analysis of most diverse genetic data set
Researchers at the University of Maryland School of Medicine (UMSOM) and their colleagues published a new analysis today in the journal
Nature from genetic sequencing data of more than 53,000 individuals, primarily from minority populations.
The early analysis, part of a large-scale program funded by the National Heart, Lung, and Blood Institute, examines one of the largest and most diverse data sets of high-quality whole genome sequencing, which makes up a person s DNA. It provides new genetic insights into heart, lung, blood and sleep disorders and how these conditions impact people with diverse racial and ethnic backgrounds, who are often underrepresented in genetic studies. ....

Jeffrey Oconnell , Akikok Bowers , Cashell Jaquish , Braxton Mitchell , E Albert Reece , Timothy Oconnor , Emily Henderson , School Of Medicine , University Of Maryland School Medicine , Institute For Genome Sciences , National Heart , Blood Institute , Maryland School , Precision Medicine , Timothyo Connor , Associate Professor , Genome Sciences , Jeffreyo Connell , Executive Vice President , Medical Affairs , Distinguished Professor , Personalized Medicine , Whole Genome Sequencing , ஜெஃப்ரி ஒக்கொண்னேழில் , காசெல் ஜாக்குஷ் , ப்ராக்ஸ்டன் மிட்செல் ,

New study reveals that daytime naps are partly regulated by genes

New study reveals that daytime naps are partly regulated by genes
How often a person takes daytime naps, if at all, is partly regulated by their genes, according to new research led by investigators at Massachusetts General Hospital (MGH) and published in
Nature Communications.
In this study, the largest of its kind ever conducted, the MGH team collaborated with colleagues at the University of Murcia in Spain and several other institutions to identify dozens of gene regions that govern the tendency to take naps during the day. They also uncovered preliminary evidence linking napping habits to cardiometabolic health.
Napping is somewhat controversial, says Hassan Saeed Dashti, PhD, RD, of the MGH Center for Genomic Medicine, co-lead author of the report with Iyas Daghlas, a medical student at Harvard Medical School (HMS). Dashti notes that some countries where daytime naps have long been part of the culture (such as Spain) now discourage the habit. Meanwhile, som ....

United States , Richa Saxena , Hassan Saeed Dashti , Jerome Lyle Rappaport , Iyas Daghlas , Marta Garaulet , Emily Henderson , Saxena Lab , Nature Communications , University Of Murcia , Harvard Medical School , Research Scholar , Massachusetts General Hospital , Genomic Medicine , United Kingdom Biobank , Saeed Dashti , Massachusetts General , Medical School , ஒன்றுபட்டது மாநிலங்களில் , ரிச்சா சகஷெண , ஹாசன் சயீத் தஷ்டி , ஜெரோம் லைல் ராப்பபோர்ட் , எமிலி ஹென்டர்சன் , சகஷெண ஆய்வகம் , இயற்கை தகவல்தொடர்புகள் , பல்கலைக்கழகம் ஆஃப் முர்சியா ,

Variants of nine genes induce a higher risk of developing Addison's disease

Variants of nine genes induce a higher risk of developing Addison s disease
Variants of nine genes increase the risk of developing Addison s disease, a rare disease in which the immune system attacks the adrenal glands. That is according to the largest genetic study to date on patients with Addison s disease. The findings help increase knowledge about what causes the disease. The study was conducted by researchers at Karolinska Institutet, Sweden, and Bergen University, Norway, and is published in the journal
Nature Communications.
By studying the single largest collection of samples from patients with Addison s disease, we ve been able to carry out the first genetic study of the disease that spans the entire human genome, says Daniel Eriksson, doctor and researcher in the experimental endocrinology group at the Department of Medicine, Solna, Karolinska Institutet, who has led the study with doctoral student Maribel Aranda and docent Sophie Bensing at the Swedish Ad ....

Daniel Eriksson , Karolinska Institutet , Sophie Bensing , Maribel Aranda , Emily Henderson , Nature Communications , Bergen University , Department Of Medicine , Swedish Addison , Norwegian Addison , Addison 39s Disease , Immune System , Rare Disease , டேனியல் எரிக்சன் , மேரிபெல் அராண்டா , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , பெர்கன் பல்கலைக்கழகம் , துறை ஆஃப் மருந்து , நோய் எதிர்ப்பு சக்தி அமைப்பு , ரேர் நோய் ,

Bizarre Coelacanth Hasn't Spent 65 Million Years Unchanged After All, Its Genome Reveals

In 1938, a living relic, thought 65 million years long extinct, was accidentally captured in a trawl net off the coast of South Africa. ....

South Africa , Isaac Yellan , Tim Hughes , University Of Toronto , Molecular Biology , Amp Quot , நேரம் ஹக்ஸ் , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , மூலக்கூறு உயிரியல் ,