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"[Sinema] is acting in her own self-interest and in the interest of people with money, so Democrats have to start early and unify," an organizer said.

Senator Kyrsten Sinema’s announcement that she would become an independent left Democrats in her state, many of whom have long wanted to defeat her in a primary, facing a new political calculus.

It’s a unique midterm year, with a Republican-friendly environment, an abortion ruling energizing Democrats, and increased partisanship in how people cast ballots.

"This significantly increases the chance that he'll run against Sinema and makes it more likely he beats her," a veteran Arizona Democrat said.

Inflation is already taking a toll on local residents' wallets and it’s shaping up to be an important theme in general elections this fall.