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Florian Naudet and colleagues argue that routine registration of observational research is needed and suggest how current processes can be adapted to facilitate it From the use of booster doses against covid-191 to approval of novel cancer therapies,2 health authorities and health technology assessment bodies are increasingly relying on non-randomised trials and observational studies. The methodological problems of observational studies, such as residual confounding,3 are difficult to resolve, but concerns about transparency and reliability can be reduced through registration. Registration is ...

Protecting against misuse without forfeiting the potential benefits is key The global market for artificial intelligence (AI) for healthcare is booming. Currently valued at $15bn (£12bn; €14bn), it is expected to near $200bn by 2030.12 Public sector spending on AI for healthcare is also on the rise. The UK government, for example, has already invested more than £123m in AI for healthcare technologies.3 Of course, previous AI “summers” were followed swiftly by AI “winters,” when the gap between expectations and the reality of AI grew too wide. This summer’s heat and longevity can ...

News reports citing unnamed sources say President Biden may seek to put noted researcher Robert Califf back in charge of the US Food and Drug Administration.