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Analysis of Proteomics Helps to Identify Drug Targets

Analysis of Proteomics Helps to Identify Drug Targets
by Angela Mohan on
March 5, 2021 at 12:14 PM
Proteomic analysis is a useful approach to identify potential novel therapeutic targets, as per the study in the journal
Oncogene. The identification of proteomic signatures are associated with clinical measures of aggressive disease for seven cancer types studied.
Some signatures were shared between different types of cancer and included cellular pathways of altered metabolism. Importantly, experimental results provided proof-of-concept that their proteomics analysis approach is a valuable strategy to identify potential therapeutic targets.
There are two notable aspects of this study. One is that we explored the proteomic landscape of cancer looking for proteins that were expressed in association with aggressive forms of cancer, said co-corresponding author Dr. Chad Creighton, professor of medicine and co-director of Cancer Bioinfor ....

Drug Targets , Cellular Pathways , Therapeutic Targets , மருந்து இலக்குகள் , செல்லுலார் பாதைகள் , சிகிச்சை இலக்குகள் ,

Proteomics analysis from aggressive human cancers can help identify potential therapeutic targets

Proteomics analysis from aggressive human cancers can help identify potential therapeutic targets
Researchers at Baylor College of Medicine show that analysis of the proteomics, or all the protein data, from aggressive human cancers is a useful approach to identify potential novel therapeutic targets.
They report in the journal
Oncogene, the identification of proteomic signatures that are associated with clinical measures of aggressive disease for each of the seven cancer types studied. Some signatures were shared between different types of cancer and included cellular pathways of altered metabolism. Importantly, experimental results provided proof-of-concept that their proteomics analysis approach is a valuable strategy to identify potential therapeutic targets. ....

Diana Monsivais , Emily Henderson , Study Co , Clinical Proteomic Tumor Analysis Consortium , Danl Duncan Comprehensive Cancer Center , Researchers At Baylor College Of Medicine , Baylor College , Chad Creighton , Cancer Bioinformatics , Study Co Corresponding Author , Uterine Cancer , எமிலி ஹென்டர்சன் , படிப்பு இணை , ஆராய்ச்சியாளர்கள் இல் பேலர் கல்லூரி ஆஃப் மருந்து , பேலர் கல்லூரி , சாட் கிரெய்டன் , புற்றுநோய் உயிர் தகவலியல் , உயிர் தகவலியல் , வளர்சிதை மாற்றம் , கருப்பை புற்றுநோய் ,

New nature communications publication by mann & theis groups harnesses the benefits of large-scale peptide collisional cross section (CCS) measurements and deep learning for 4D-proteomics

New Nature Communications publication by Mann & Theis Groups harnesses the benefits of large-scale peptide collisional cross section (CCS) measurements and deep learning for 4D-proteomics
Bruker Corporation today announces a seminal publication from the groups of Professors Matthias Mann and Fabian Theis in the journal Nature Communications with the title ‘Deep learning the collisional cross sections of the peptide universe from a million experimental values’ by Florian Meier et al. (doi.org/10.1038/s41467-021-21352-8).
Figure 1. Large-scale peptide collisional cross section (CCS) measurement with TIMS and PASEF. From Deep learning the collisional cross sections of the peptide universe from a million experimental values . (a) Workflow from extraction of whole-cell proteomes through digestion, fractionation, and chromatographic separation of each fraction. The TIMS-quadrupole TOF mass spectrometer was operated in PASEF mode. (b) Overview of the CCS dataset in this stud ....

Matthias Mann , Bruker Daltonicsmar , Gary Kruppa , Florian Meier , Fabian Theis , Nature Communications , University Of Copenhagen , Jena University Hospital , German Research Center , Max Planck Institute Of Biochemistry , Environmental Health , Novo Nordisk Foundation Center , Protein Research , Helmholtz Center Munich , Department Of Mathematics , Bruker Corporation , From Bruker Daltonicsmar , Professors Matthias Mann , Source Data , Professor Matthias Mann , Max Planck Institute , Professor Fabian Theis , Assistant Professor , Functional Proteomics , Pan Human , Bruker Vice President ,

Proteomics analysis IDs potential drug targets for aggressive cancers

Researchers at Baylor College of Medicine show that analysis of the proteomics, or all the protein data, from aggressive human cancers is a useful. ....

United States , Baylor College Of Medicine , Darshans Chandrashekar , Yiqun Zhang , Diana Monsivais , Sooryanarayana Varambally , Yasmin Vasquez , Ramyap Masand , Fengju Chen , Johnc Faver , Michaele Scheurer , Martinm Matzuk , Burroughs Wellcome Fund , University Of Texas Md Anderson Cancer Center , National Institutes Of Health , Clinical Proteomic Tumor Analysis Consortium , Researchers At Baylor College Of Medicine , University Of Alabama At Birmingham , Cancer Prevention Research Institute Of Texas , Children Brain Tumor Tissue Consortium , Danl Duncan Comprehensive Cancer Center , Cancer Genome Atlas Consortium , Baylor College , Chad Creighton , Cancer Bioinformatics , Texas Children ,

SARS-CoV-2 modulates host cell central carbon metabolism for reproduction

SARS-CoV-2 modulates host cell central carbon metabolism for reproduction
A team of scientists from Sweden and India has recently characterized the host cell metabolic alterations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Their findings reveal that SARS-CoV-2 modulates the host cell s central carbon metabolism to facilitate replication and infection propagation. Moreover, they observe that the severity of coronavirus disease 2019 (COVID-19) primarily depends on the blood levels of glucose, mannose, and glutamate. The study is currently available on the
Background
Since its emergence in late December 2019 in Wuhan, China, SARS-CoV-2, the causative pathogen of COVID-19 disease, has infected 114 million people and claimed 2.52 million lives globally. ....

Sanchari Sinha Dutta , Amino Acid , Corona Virus , Coronavirus Disease Covid 19 , In Vitro , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , சஞ்சரி சீன்ஹா தத்தா , அமினோ அமிலம் , கொரோனா வைரஸ் , நீரிழிவு நோய் , இல் விட்ரோ , வளர்சிதை மாற்றம் , உடல் பருமன் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,