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Effect of combination treatment with glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors on incidence of cardiovascular and serious renal events: population based cohort study

Objective To determine whether the combined use of glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors is associated with a decreased risk of major adverse cardiovascular events and serious renal events compared with either drug class alone among patients with type 2 diabetes, and to assess the effect of the combination on the individual components of major adverse cardiovascular events, heart failure, and all cause mortality.

Design Population based cohort study using a prevalent new-user design, emulating a trial.

Setting UK Clinical Practice Research Datalink linked to Hospital Episode Statistics Admitted Patient Care and Office for National Statistics databases.

Participants Two prevalent new-user cohorts were assembled between January 2013 and December 2020, with follow-up until the end of March 2021. The first cohort included 6696 patients who started GLP-1 receptor agonists and added on SGLT-2 inhibitors, ....

United Kingdom , City Of , Canadian Institutes Of Health Research , Setting United Kingdom Clinical Practice Research Datalink , British National Formulary , Research Scholar , United Kingdom Clinical Practice Research Datalink , Regulatory Agency , Research Data Governance , English National Health Service , Foundation Scheme , Office For National Statistics , Research Ethics Board Of The Jewish , Clinical Practice Research Datalink , Research Ethics Board , Mcgill University , United Kingdom National Health Service , Hospital Episode Statistics Admitted Patient Care , National Statistics , United Kingdom Medicines , United Kingdom Data Protection Act , Chercheur Boursier Clinicien Junior , Fonds De Recherche , Distinguished James Mcgill Award , Distinguished Research Scholar , William Dawson Scholar Award ,

Effect of timeframes to define long term conditions and sociodemographic factors on prevalence of multimorbidity using disease code frequency in primary care electronic health records: retrospective study

Effect of timeframes to define long term conditions and sociodemographic factors on prevalence of multimorbidity using disease code frequency in primary care electronic health records: retrospective study
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United Kingdom , Mark Cunningham , Research Data Governance , Clinical Practice Research Datalink , Clinical Practice Research Datalink Aurum , Institute Of Global Health Innovation , Multiple Deprivation , Data Governance Process , Big Data , Analytical Unit , Global Health ,

The effectiveness of COVID-19 vaccines to prevent long COVID symptoms: staggered cohort study of data from the UK, Spain, and Estonia

The effectiveness of COVID-19 vaccines to prevent long COVID symptoms: staggered cohort study of data from the UK, Spain, and Estonia
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United Kingdom , Astra Zeneca , National Institute For Health , Department Of Family Medicine , European Medicines Agency , University Of Tartu , European Regional Development Fund , Innovative Medicines Initiative , Observational Medical Outcomes Partnership , University Of Oxford , Clinical Practice Research Datalink , Research Data Governance , Evidence Network , Public Health , European Health Data , Estonian Ministry Of Social Affairs , United Kingdom Clinical Practice Research Datalink , Care Research , European Federation Of Pharmaceutical Industries , Spain Information System For Research , Information System , Primary Care , Innovative Medicines , Synapse Management Partners , Estonian Ministry , Social Affairs ,

Sociodemographic characteristics and longitudinal progression of multimorbidity: A multistate modelling analysis of a large primary care records dataset in England

In this multistate modelling analysis, Sida Chen and colleagues examine sociodemographic characteristics and longitudinal progression of multimorbidity using data from primary care records in England ....

United Kingdom , West Midlands , United Kingdom General , City Of , Singula Bio , Astra Zeneca , Eli Lilly , Davida Mcallister , Adult Psychiatric Morbidity Survey , Adult Psychiatric Morbidity , Health Research Board Ireland , Research Database , Scientific Advisory Committee , National Institute For Health Research , Cancer Research United Kingdom , Clinical Practice Research Datalink , Derby Research Ethics Committee , Research Data Governance , Health Research Authority , Research Council , University Of Edinburgh , Novo Nordisk , Cambridge Service For Data Driven Discovery , Roche Ltd , Boehringer Ingelheim , Creative Commons Attribution License ,

World Rare Disease Day - Global Genes

World Rare Disease Day - Global Genes
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District Of Columbia , United States , Capitol Hill , Salt Lake City , University Of Utah , Careaboutrare Globalgenes Rarediseaseday , Karmen Trzupek , Megan Oboyle , Mary Morlino , Nick Ehly , Vanessa Vogel Farley , Broad Institute , Patient Services , Products Grants Program , Rare Disease Stats Community Stories , Research Data Governance , Everylife Foundation , Rare Disease Diversity Coalition Reception , Department Of Clinical , Community Events Hub , Termeer Foundation , Program Coordinator , Rare Compassion Program , Rare Disease Research , Your Organization To Get , World Rare Disease Day ,