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Time to Treatment With Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic Stroke: A Meta-Analysis | Cerebrovascular Disease | JAMA

This individual participant data meta-analysis assesses treatment time from stroke symptom onset and disability level after treatment with intravenous thromboly ....

Noord Holland , United States , Van Zwam , Johannes Kaesmacher , Swiss Neurological Society , Boehringer Ingelheim , University Of Bern , Endovascular Stroke Center , University Hospital Bern , R Foundation For Statistical Computing , European Commission , International Stroke Conference , Netherlands Organization For Health , European Stroke Organisation , Amsterdam University Medical Centers , National Institutes Of Health Stroke Scale , Alberta Stroke Program Early Ct Score , European Society For Minimally Invasive Neurological Therapy , Stroke Center , Group Information , Dutch Heart Foundation , Swiss National Science Foundation , Rankin Scale , Improving Reperfusion Strategies , Ischemic Stroke , Inclusion Criteria ,

Effectiveness of Bivalent mRNA COVID-19 Vaccines in Preventing SARS-CoV-2 Infection in Children and Adolescents Aged 5 to 17 Years | Public Health | JAMA

This study uses data from 3 prospective cohort studies conducted in the US to assess vaccine effectiveness of bivalent COVID-19 vaccines against SARS-CoV-2 infe ....

United States , North Carolina , University Of Arizona , Sanofi Pasteur , Leorar Feldstein , Briggs Hagen , Ark Biopharma , Burroughs Wellcome Fund , Florida Firefighter Cancer Initiative , Flu Lab , Florida Department Of Health , Texas Pediatric Society , National Institute Of Allergy , Institute Inc , Kaiser Foundation Hospitals , Community Vaccine Effectiveness , National Center , American College Of Occupational , Drug Administration , Us Centers For Disease , Abt Associates , R Foundation For Statistical Computing , Abt Associates Inc , Centers For Disease , Laboratory Testing , University Of Michigan ,

Top-predator recovery abates geomorphic decline of a coastal ecosystem

The recovery of top predators is thought to have cascading effects on vegetated ecosystems and their geomorphology1,2, but the evidence for this remains correlational and intensely debated3,4. Here we combine observational and experimental data to reveal that recolonization of sea otters in a US estuary generates a trophic cascade that facilitates coastal wetland plant biomass and suppresses the erosion of marsh edges—a process that otherwise leads to the severe loss of habitats and ecosystem services5,6. Monitoring of the Elkhorn Slough estuary over several decades suggested top-down control in the system, because the erosion of salt marsh edges has generally slowed with increasing sea otter abundance, despite the consistently increasing physical stress in the system (that is, nutrient loading, sea-level rise and tidal scour7–9). Predator-exclusion experiments in five marsh creeks revealed that sea otters suppress the abundance of burrowing crabs, a top-d ....

United States , Elkhorn Slough , Sea Otter Enhydra , Sea Otter , Rr Core Team , Yellowstone National Park , Wildlife Service , Environmental Systems Research Institute , Elkhorn Slough Foundation , Human Impacts , Salt Marshes , Global Perspective , California Press , New England , Coastal Zones , Environmental Changes , Atlantic Sarcocornia Dominated , California Estuary , Marsh Conservation , Enhancement Opportunities , Around Elkhorn Slough , Sea Level , Elkhorn Slough Technical Report Series , Tidal Scour , Sediment Transport , San Jos ,

1-year weight change after diabetes diagnosis and long-term incidence and sustainability of remission of type 2 diabetes in real-world settings in Hong Kong: An observational cohort study

In this population based cohort study of >37,000 people in Hong Kong, Hongjiang Wu and colleagues examine 1-year weight change after diabetes diagnosis with long-term incidence and sustainability of diabetes remission. ....

Hong Kong , University Of Hong Kong , Hong Kong General , Eli Lilly , Merck Serono , Junshi Biosciences , Astra Zeneca , Daiichi Sankyo , Hospital Authority , Tricida Inc , Management Programme For Diabetes Mellitus , International Consensus , Hong Kong Hospital Authority , Novo Nordisk , Chinese University Of Hong Kong , Boehringer Ingelheim , R Foundation For Statistical Computing , Risk Assessment , Management Programme , Diabetes Mellitus , Creative Commons Attribution License , Hong Kong Hospital , Lee Pharmaceutical , Shanghai Junshi Biosciences , Applied Therapeutics , Hua Medicine ,

Tropical cyclone-specific mortality risks and the periods of concern: A multicountry time-series study

Author summary Why was this study done? Tropical cyclones (TCs), among the most destructive and costliest climate extreme events, are expected to be more intense due to climate change. Despite the widely acknowledged hazards, a consistent and quantitative assessment of the mortality risks of TC across countries is lacking. Such quantitative and comparable evidence across countries is urgently required to better understand the health effects and respond to the potentially increasing hazards. No previous studies have characterized the periods of concern (POC), exposure-response (ER) relationship, and temporal trends of the TC health risks, directly relevant to more precise and effective preparedness and mitigation strategies. What did the researchers do and find? Using mortality data from 494 TC-exposed locations in 18 countries or territories, we quantified the TC-specific mortality risks and POC of the 382 TC events that affected these locations. The ER relationships and temporal ....

United States , South Korea , New Zealand , Puerto Rico , United Kingdom , Republic Of , South Australia , Sharon Harrison , International Classification Of Diseases , German Federal Ministry Of Education , Asia Joint Research Program Grant , International Best Track Archive For Climate Stewardship , Monash International Tuition Scholarship , Natural Environment Research Council United Kingdom , Research Council , Zealand Ministry Of Health , Health Research Council Of New Zealand , Leader Fellowship Of The Australian National Health , Foundation For Statistical Computing , Career Development Fellowship , Vichealth Postdoctoral Research Fellowships , Us Center , Australian National Health , China Scholarship Council , Collaborative Research Network , Research Council United Kingdom ,