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Judith Leblanc and co-workers report a cluster-randomized trial evaluating intensive screening for SARS-CoV-2 infection in emergency departments.
Type 2 diabetes mellitus (T2D), a major cause of worldwide morbidity and mortality, is characterized by dysfunction of insulin-producing pancreatic islet β cells1,2. T2D genome-wide association studies (GWAS) have identified hundreds of signals in non-coding and β cell regulatory genomic regions, but deciphering their biological mechanisms remains challenging3–5. Here, to identify early disease-driving events, we performed traditional and multiplexed pancreatic tissue imaging, sorted-islet cell transcriptomics and islet functional analysis of early-stage T2D and control donors....
This randomized trial assesses whether prone vs supine positioning decreases the time to successful weaning of extracorporeal membrane oxygenation (ECMO) in pat
This clinical trial compares the efficacy of intubation withholding vs routine practice on clinical outcomes of comatose patients with acute poisoning and a Gla
In a randomized controlled trial, Antti P Launonen and team compare outcomes of non-operative to operative treatment in patients aged ≥ 60 years with 3-4 part dislocated proximal humerus fractures.