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This AI tool may reduce gum disease inflammation

This AI tool may reduce gum disease inflammation
drbicuspid.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from drbicuspid.com Daily Mail and Mail on Sunday newspapers.

China , Shanghai , Yuan-li , Fujian , J-clin-periodontol , Shanghai-jiao-tong-university-school-of-medicine , Shanghai-jiao-tong-university-school , Creative-commons-noncommercial ,

Efficacy of a single low dose of esketamine after childbirth for mothers with symptoms of prenatal depression: randomised clinical trial

Objective To determine whether a single low dose of esketamine administered after childbirth reduces postpartum depression in mothers with prenatal depression.

Design Randomised, double blind, placebo controlled trial with two parallel arms.

Setting Five tertiary care hospitals in China, 19 June 2020 to 3 August 2022.

Participants 364 mothers aged ≥18 years who had at least mild prenatal depression as indicated by Edinburgh postnatal depression scale scores of ≥10 (range 0-30, with higher scores indicating worse depression) and who were admitted to hospital for delivery.

Interventions Participants were randomly assigned 1:1 to receive either 0.2 mg/kg esketamine or placebo infused intravenously over 40 minutes after childbirth once the umbilical cord had been clamped.

Main outcome measures The primary outcome was prevalence of a major depressive episode at 42 days post partum, diagnosed using the mini-international neuropsychiatric interview. Secondary outcomes included the Edinburgh postnatal depression scale score at seven and 42 days post partum and the 17 item Hamilton depression rating scale score at 42 days post partum (range 0-52, with higher scores indicating worse depression). Adverse events were monitored until 24 hours after childbirth.

Results A total of 364 mothers (mean age 31.8 (standard deviation 4.1) years) were enrolled and randomised. At 42 days post partum, a major depressive episode was observed in 6.7% (12/180) of participants in the esketamine group compared with 25.4% (46/181) in the placebo group (relative risk 0.26, 95% confidence interval (CI) 0.14 to 0.48; P<0.001). Edinburgh postnatal depression scale scores were lower in the esketamine group at seven days (median difference −3, 95% CI −4 to −2; P<0.001) and 42 days (−3, −4 to −2; P<0.001). Hamilton depression rating scale scores at 42 days post partum were also lower in the esketamine group (−4, −6 to −3; P<0.001). The overall incidence of neuropsychiatric adverse events was higher in the esketamine group (45.1% (82/182) v 22.0% (40/182); P<0.001); however, symptoms lasted less than a day and none required drug treatment.

Conclusions For mothers with prenatal depression, a single low dose of esketamine after childbirth decreases major depressive episodes at 42 days post partum by about three quarters. Neuropsychiatric symptoms were more frequent but transient and did not require drug intervention.

Trial registration ClinicalTrials.gov [NCT04414943][1].

Anonymised individual patient data can be made available to researchers who provide a sound proposal and ethical approval, considering possible legal restrictions of China. Requests should be sent to corresponding author (wangdongxin@hotmail.com or dxwang65@bjmu.edu.cn).

[1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT04414943&atom=%2Fbmj%2F385%2Fbmj-2023-078218.atom

Peking , Beijing , China , Ming-jiang , Guangxi , Yuan-li , Fujian , United-states , Zhejiang , Liang-chen , Hainan , Edinburgh

14 charges for two men accused of Elizabeth River fish poaching

14 charges for two men accused of Elizabeth River fish poaching
dailypress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from dailypress.com Daily Mail and Mail on Sunday newspapers.

Elizabeth-river , Virginia , United-states , Yuan-li , Fujian , China , Chao-chen , Shaanxi , Norfolk , Bi-chen , Jiangsu , Chinese

Tangzu Wan'er S.G In-Ear Monitors (IEM) Review, tangzu wan'er

Introduction Tangzu is a new brand established in 2021 by an experienced team in the audio industry. The brand's first product, Yuan Li, and the latest IEM, Tangzu Wan'er S.G, showcase their expertise. In this

India , China , Yuan-li , Fujian , Chinese , Tangzu-waner , Fit-the , Remarkable-dynamic-driver-performance , Ear-monitors-headphone , Wired-earbuds , Musician-audiophile

Room Temperature Superconductors? Not So Fast… – Yale Scientific Magazine

Room Temperature Superconductors? Not So Fast… – Yale Scientific Magazine
yalescientific.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from yalescientific.org Daily Mail and Mail on Sunday newspapers.

South-korea , Peking , Beijing , China , Seoul , Soult-ukpyolsi , Yuan-li , Fujian , Ashkan-salamat , Heike-kamerlingh-onnes , Kara-tao , Ranga-dias

Painting History in the Making to Guide and Uplift Humanity

Painting History in the Making to Guide and Uplift Humanity
theepochtimes.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from theepochtimes.com Daily Mail and Mail on Sunday newspapers.

China , Taiwan , Yuan-li , Miaoli-xian , New-york , United-states , Hong-kong , Taiwanese , Chinese , Falun-gong , Falun-dafa , Samira-bouaou

International Day of Education: Asia's most influential educators are shaping the future

To secure a future with equality and abundance, these visionary leaders from Tatler Asia's Most Infuential list are strengthening educational systems in the region.

London , City-of , United-kingdom , Singapore , Taipei , T-ai-pei , Taiwan , China , Hong-kong , Diliman , Bulacan , Philippines

CDT Editors' Picks: The Best of 2023

CDT Editors' Picks: The Best of 2023
chinadigitaltimes.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from chinadigitaltimes.net Daily Mail and Mail on Sunday newspapers.

Hong-kong , Guiyang , Guizhou , China , Kenya , Yuan-li , Fujian , Sichuan , Gansu , Xiao-qiang , Shaanxi , New-york

Competition Winners: Traditional Oil Painting at Its Best

Competition Winners: Traditional Oil Painting at Its Best
theepochtimes.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from theepochtimes.com Daily Mail and Mail on Sunday newspapers.

New-york , United-states , Italy , Taiwan , Yu-chen , Zhejiang , China , Yuan-li , Miaoli-xian , Japan , France , Brazil

Night School Becomes New Fashion As Young Chinese Seek Pressure Relief, Enriched Lives

Night School Becomes New Fashion As Young Chinese Seek Pressure Relief, Enriched Lives
brudirect.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from brudirect.com Daily Mail and Mail on Sunday newspapers.

Gao-yang , Fujian , China , Shanghai , Shandong , Jiangsu , Jinan , Wuhan , Hubei , Yuan-li , Chinese , Yue-mengyu