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Taysha Gene Therapies : Reports Second Quarter 2021 Financial Results and Provides Corporate Update

Positive pre-IND/CTA feedback obtained from several key regulatory agencies for TSHA-102 in Rett syndrome, TSHA-101 in GM2 gangliosidosis and TSHA-118 in CLN1 disease, paving the way for multiple. | August 17, 2021 ....

United States , Omary Newman , Beta Hexoseaminidase , Silicon Valley Bank , Rare Disease Company Coalition , Queen University , Us National Institutes Of Health , Exchange Commission , Development Rd Expenses , Taysha Gene Therapies Inc , Regulatory Affairs At Astellas Gene Therapies , Ut Southwestern Gene Therapy Program , Taysha Gene Therapies , Intramural Program , National Institute , Neurological Disorders , Principal Investigator , Chief Development Officer , Senior Vice President , Regulatory Affairs , Astellas Gene Therapies , Investigational New Drug , Investor Day , Gene Therapies , Gene Therapy Program , Private Securities Litigation Reform Act ,

No Difference in Cognitive Decline After CABG vs PCI

No Difference in Cognitive Decline After CABG vs PCI
medscape.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medscape.com Daily Mail and Mail on Sunday newspapers.

Johns Hopkins University , United States , National Institutes Of Health , San Francisco , Department Of Anesthesia Perioperative Care , University Of California , Department Of Neurology , Johns Hopkins University School Of Medicine , Intramural Program , Stroke Branch , National Institute Of Neurological Disorders , Retirement Study , Perioperative Care , Memory Study , Telephone Interview , Cognitive Status , Medicare Advantage , Stroke Branch Chief , Senior Investigator , National Institute , Neurological Disorders , National Institutes , Johns Hopkins University School , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் , ஒன்றுபட்டது மாநிலங்களில் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் ,

Two regions in the canine genome explain one third of the risk of rare blood cancer

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Mutations in two genetic regions in dogs explain over one third of the risk of developing an aggressive form of hematological cancer, according to a study led by Jacquelyn Evans and Elaine Ostrander at the National Human Genome Research Institute in Maryland, USA and colleagues. The study, which combined multiple sequencing techniques to investigate histiocytic sarcoma in retriever dogs, publishes May 13 in the open-access journal
PLOS Genetics.
Histiocytic sarcoma is an aggressive cancer of immune cells, and although extremely rare in humans, it affects around one-in-five flat-coated retrievers. Genome-wide association surveys of 177 affected and 132 unaffected flat-coated retrievers identified two loci on chromosomes 5 and 19 of the canine genome associated with histiocytic sarcoma. Whole genome, transcriptome, and chromatin immunoprecipitation (CHiP) sequence data revealed that the CFA5 locus contains mutations near a known tumor-suppressor gene, PIK3R ....

United States , Elaine Ostrander , Jacquelyn Evans , Flint Animal Cancer Center , National Human Genome Research Institute , European Commission , United Kingdom Flatcoated Retriever Society , Sciences Postdoctoral Research Associate Training , National Institute , Intramural Program , Zoology Veterinary Science , Pets Ethology , ஒன்றுபட்டது மாநிலங்களில் , எலைன் ஒஸ்திறாந்டேர் , ஜாக்குலின் எவன்ஸ் , பிளின்ட் விலங்கு புற்றுநோய் மையம் , தேசிய மனிதன் மரபணு ஆராய்ச்சி நிறுவனம் , ஐரோப்பிய தரகு , தேசிய நிறுவனம் , அகச்சிதைவு ப்ரோக்ர்யாம் ,

The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

Among the most promising therapeutic options for individuals with coronavirus disease 2019 (COVID-19) are monoclonal antibodies (mAbs). In this study, Jones et al . identified, characterized, and tested one such mAb, LY-CoV555, in vitro and in vivo. They found that LY-CoV555 bound to the severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) spike protein and prevented its interaction with angiotensin-converting enzyme 2. Prophylactic treatment with LY-CoV555 protected the upper and lower respiratory tracts of nonhuman primates from becoming infected with SARS-CoV-2. Together, these data support the clinical use of LY-CoV555 for treating patients with COVID-19.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a public health threat for which preventive and therapeutic agents are urgently needed. Neutralizing antibodies are a key class of therapeutics that may bridge widespread vaccination campaigns and offer a treatment solution in populations le ....

South Africa , United States , United Kingdom , K Huntington Eli Lilly , Gatan Solarus , Isoplates Perkinelmer , Eli Lilly , Oxford Cryosystems , Carterra Epitope , Us Department Of Defense , National Institute Of Allergy , Grossman School Of Medicine Startup , Lilly Research Laboratories Collaborative Access Team , Burroughs Wellcome Fund Postdoctoral Enrichment Program Award , Us Department Of Energy , International Patent Application No , Electron Microscopy Sciences , Office Of Science , Committee Of Bioqual Inc , Argonne National Laboratory , Centers For Disease , European Union Horizon , Laboratory Animals , Abcellera Biologics Inc , National Institutes Of Health , P Sipahimalani Abcellera Biologics Inc ,

Risk of miscarriage in women with chronic diseases in Norway: A registry linkage study

Risk of miscarriage in women with chronic diseases in Norway: A registry linkage study
Maria C. Magnus ,
Roles
Investigation,
Methodology,
Writing – review & editing
Affiliations
Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway,
Department of Clinical Science, University of Bergen, Bergen, Norway,
Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
⨯
Knut-Arne Wensaas,
Affiliation
Research Unit for General Practice, NORCE Norwegian Research Centre, Bergen, Norway
Roles
Conceptualization,
Investigation,
Methodology,
Writing – review & editing
Affiliation
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America
⨯
Siri E. Håberg ....

City Of , United Kingdom , Jennye Myers , International Classification Of Diseases , University Of Manchester , Health Research Ethics South East , Regional Committee For , International Classification Of Primary Care , Research Council , University Of Bristol , Research Council Of Norway , Morkenn H , Wensaask A , Creative Commons , Intramural Program , National Institute , Environmental Health Sciences , Medical Research Council , Integrative Epidemiology Unit , International Classification , Primary Care , Observational Routinely Collected Data , Observational Studies , Medical Birth Registry , Norwegian Patient Registry , Supplement Methods ,