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New therapeutic target for Huntington's treatment

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IMAGE: From left to right: Mercè Masana, Ana Gámez-Valero, Eulàlia Martí, Anna Guisado-Corcoll, Esther Pérez-Navarro and Maria Solaguren-Beascoa.
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Credit: UNIVERSITY OF BARCELONA
Huntington s disease is caused by a mutation in the Huntingtin gene (HTT), which appears in adults and features motor, cognitive and psychiatric alterations. The origin of this disease has been associated with the anomalous functioning of the mutated protein: mHTT, but recent data showed the involvement of other molecular mechanisms.
A new study conducted by the University of Barcelona has identified a type of ribonucleic acid (RNA) as a potential therapeutic target for the treatment of the disease. These are the small RNA, or sRNAs, molecules that do not code proteins but have important functions in the regulation of gene expression. According to the study, sRNAs would take part in the development of the disease, results that shed light on the design ....

Comunidad Autonoma De Cataluna , Acta Neuropathologica , University Of Barcelona , University Medical Center , Health Sciences Eul , Biomedical Research Networking Center On Neurodegenerative Diseases , Institute Of Neurosciences , Pii Sunyer Biomedical Research Institute , Public Health Networking Biomedical Research Centre , Biomedical Research Networking Center , Neurodegenerative Diseases , Sunyer Biomedical Research Institute , Genomic Regulation , Medicine Health , Pharmaceutical Science , Gene Therapy , Disease In The Developing World , காமுனிடட தன்னாட்சி டி கடலுள் , பல்கலைக்கழகம் ஆஃப் பார்சிலோனா , பல்கலைக்கழகம் மருத்துவ மையம் , நிறுவனம் ஆஃப் நரம்பியல் , பொது ஆரோக்கியம் நெட்வொர்க்கிங் உயிர் மருத்துவ ஆராய்ச்சி மையம் , உயிர் மருத்துவ ஆராய்ச்சி நெட்வொர்க்கிங் மையம் , மருந்து ஆரோக்கியம் , மருந்து அறிவியல் , கீந் சிகிச்சை ,

Largest comprehensive Middle East GWAS reveals Arab genetic risk factors

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IMAGE: Dr. Omar Albagha, one of the principal investigators of Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits , Nature Communications 2021
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Credit: Qatar Foundation
Doha, Qatar - (February 23, 2021) - A group of researchers at Qatar Foundation have reported the first and largest genetic association study in the Middle East, that has been published online in
Nature Communications - a leading a peer-reviewed, open access, scientific journal published by Nature Research.
The study titled Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits highlights a vital piece of information wherein now there is a better understanding of the genetic risk factors that are specific to the Arab population, including those that are shared with other ethnicities. ....

Ad Daw Ah , Khalifa Al , Sheikha Moza , Weill Cornell , Karsten Suhre , Omar Albagha , Nature Communications , College Of Health , Nature Research , Qatar Genome Research Consortium , Qatar Foundation For Education , Feto Maternal Center , Qatar Foundation Qf Hamad Bin Khalifa University , Development Innovation , Qatar Foundation , Hamad Bin Khalifa University , Health Care Corporation , Qf Research , Community Development , Hamad Medical Corporation , Cornell University , Ministry Of Public Health , Life Sciences , Qatar Genome Program , Qatar Genome Program Research , Middle East ,

Evan Snyder named Fellow of the American Institute for Medical and Biological Engineering

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IMAGE: Evan Y. Snyder, M.D., Ph.D., professor and founding director of the Center for Stem Cells and Regenerative Medicine at Sanford Burnham Prebys Medical Discovery Institute.
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Credit: Sanford Burnham Prebys Medical Discovery Institute
LA JOLLA, CALIF. - Feb. 23, 2021 - The American Institute for Medical and Biological Engineering (AIMBE) has elected to its College of Fellows Evan Y. Snyder, M.D., Ph.D., professor and founding director of the Center for Stem Cells and Regenerative Medicine at Sanford Burnham Prebys Medical Discovery Institute. Snyder was nominated, reviewed, and elected by his peers and members of the College of Fellows for his seminal contributions to regenerative medicine. He will be inducted to AIMBE during a formal ceremony held on March 26, 2021. ....

United States , Sandra Leibel , Gene Therapy Advisory Committee , College Of Fellows Evany Snyder , Harvard Medical School , National Academy Of Medicine , National Academy Of Sciences , National Academy Of Engineering , College Of Fellows , University Of Pennsylvania , American Institute For , Presidential Medal Of Technology , American Institute , Biological Engineering , Fellows Evan , Stem Cells , Regenerative Medicine , Sanford Burnham Prebys Medical Discovery , Nobel Prize , Presidential Medal , National Academy , Gene Therapy Advisory , Boston Children , Biomedical Environmental Chemical Engineering , Cell Biology , Developmental Reproductive Biology ,

Do people with migraine get enough exercise?

More than two-thirds of people with migraine do not get enough exercise, according to a preliminary study released today, February 23, 2021, that will be presented at the American Academy of Neurology s 73rd Annual Meeting being held virtually April 17 to 22, 2021. ....

United States , Mason Dyess , American Academy Of Neurology Annual Meeting , World Health Organization , University Of Washington , American Academy Of Neurology , American Academy , Annual Meeting , World Health , Medicine Health , ஒன்றுபட்டது மாநிலங்களில் , கொத்தனார் சாயம் , அமெரிக்கன் கலைக்கழகம் ஆஃப் நரம்பியல் ஆண்டு சந்தித்தல் , உலகம் ஆரோக்கியம் ஆர்கநைஸேஶந் , பல்கலைக்கழகம் ஆஃப் வாஷிங்டன் , அமெரிக்கன் கலைக்கழகம் ஆஃப் நரம்பியல் , அமெரிக்கன் கலைக்கழகம் , ஆண்டு சந்தித்தல் , உலகம் ஆரோக்கியம் , மருந்து ஆரோக்கியம் ,

Seasonal variation in daylight influences brain function

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IMAGE: Brain opioid receptors measured with positron emission tomography (A) and regions, where opioid receptor density varied seasonally.
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Credit: University of Turku
Seasons have an impact on our emotions and social life. Negative emotions are more subdued in the summer, whereas seasonal affective disorder rates peak during the darker winter months. Opioids regulate both mood and sociability in the brain.
In the study conducted at the Turku PET Centre, Finland, researchers compared how the length of daylight hours affected the opioid receptors in humans and rats.
In the study, we observed that the number of opioid receptors was dependent on the time of the year the brain was imaged. The changes were most prominent in the brain regions that control emotions and sociability. The changes in the opioid receptors caused by the variation in the amount of daylight could be an important factor in seasonal affective disorder, say ....

Lihua Sun , Lauri Nummenmaa , Emrah Yatkin , Anne Roivainen , University Of Turku , Central Animal Laboratory , Turku University Hospital , Postdoctoral Researcher Lihua Sun , Professor Lauri Nummenmaa , Positron Emission Tomography , Professor Anne Roivainen , Social Behavioral Science , Mental Health , பல்கலைக்கழகம் ஆஃப் டர்கு , மைய விலங்கு ஆய்வகம் , டர்கு பல்கலைக்கழகம் மருத்துவமனை , பாஸிட்ராந் உமிழ்வு டோமோகிராபி , சமூக நடத்தை அறிவியல் , மன ஆரோக்கியம் ,