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Rare Mutations May Have Big Impact on Schizophrenia Pathology


Korea Advanced Institute of Science and Technology
Somatic mutations found only in brain cells disrupt synaptic function
Schizophrenia is a neurodevelopmental disorder that disrupts brain activity, producing hallucinations, delusions, and other cognitive disturbances. Researchers have long searched for genetic influences in the disease, but genetic mutations have been identified in only a small fraction fewer than a quarter of sequenced patients. Now a study shows that “somatic” gene mutations in brain cells could account for some of the disease’s neuropathology.
The results of the study, led by Professor Jeong Ho Lee at the Graduate School of Medical Science and Engineering in collaboration with the Stanley Medical Research Institute in the US, appeared in Biological Psychiatry. ....

South Korea , John Krystal , School Of Medical Science , Stanley Medical Research Institute , Korea Advanced Institute Of Science , Professor Jeong Ho Lee , Graduate School , Medical Science , Korea Advanced Institute , Biological Psychiatry , Korea Advanced Institute Of Science And Technology , Agenetic Mutation , Medical Research , Brain Activity , Gene Mutations , தெற்கு கொரியா , ஜான் கிரிஸ்டல் , பள்ளி ஆஃப் மருத்துவ அறிவியல் , ஸ்டான்லி மருத்துவ ஆராய்ச்சி நிறுவனம் , ப்ரொஃபெஸர் ஜியோங் ஹோ லீ , பட்டதாரி பள்ளி , மருத்துவ அறிவியல் , உயிரியல் மனநல மருத்துவம் , ஜெநெடிக் பிறழ்வு , மருத்துவ ஆராய்ச்சி , மூளை நடவடிக்கை ,

Skeleton of malaria parasite reveals its secrets


Date Time
Skeleton of malaria parasite reveals its secrets
Research teams from UNIGE have discovered that the cytoskeleton of the malaria parasite comprises a vestigial form of an organelle called conoid, initially thought to be absent from this species and which could play a role in host invasion.
Plasmodium at the ookinete stage viewed by expansion microscopy. The image shows the cytoskeleton of the pathogen following the labelling of tubulin. The conoid is the ring visible at the upper tip of the cell. © UNIGE/HAMEL
Plasmodium is the parasite causing malaria, one of the deadliest parasitic diseases. The parasite requires two hosts -the Anopheles mosquito and the human- to complete its life cycle and goes through different forms at each stage of its life cycle. Transitioning from one form to the next involves a massive reorganisation of the cytoskeleton. Two teams from the University of Geneva (UNIGE) have shed new light on the cytoskeleton organisation in Plasm ....

Virginie Hamel , Department Of Microbiology , University Of Geneva , Cell Biology , Vestigial Form , Mathieu Brochet , Molecular Medicine , கன்னி ஹ்யாமல் , துறை ஆஃப் நுண்ணுயிரியல் , பல்கலைக்கழகம் ஆஃப் ஜிநீவ , செல் உயிரியல் , ம்யாத்யு சிற்றேடு , மூலக்கூறு மருந்து ,