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Frontiers | Downregulation of CD45 Signaling in COVID-19 Patients Is Reversed by C24D, a Novel CD45 Targeting Peptide

CD45, the predominant transmembrane tyrosine phosphatase in leukocytes, is required for the efficient induction of T cell receptor signaling and activation. Various studies have demonstrated that viruses can interfere with the functions of CD45 and that patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are immune-suppressed. We recently reported that the CD45-intracellular signals in peripheral blood mononuclear cells (PBMCs) of triple negative breast cancer (TNBC) patients are inhibited. We also reported that C24D, an immune modulating therapeutic peptide, binds to CD45 on immune-suppressed cells and resets the functionality of the immune system via the CD45 signaling pathway. Given the similarity between the role of CD45 in viral immune suppression, reported by others, and our findings on TNBC, we hypothesized that the C24D peptide may have a similar “immune-resetting” effect. We tested this hypothesis by comparing the CD45 intracellular signaling in PBMC ....

United States , United Kingdom , Kfar Saba , Tel Hashomer , Dawen Yu , Gen Virol , Blood Bank Mada Tel Hashomer , Meir Medical Center , World Health Organization , Institutional Review Board At Meir Medical Center , Ethics Committees Of The Meir Medical Center , National Health Commission Of Israel , Israel Ministry Of Health , Synpeptide Co Ltd , Ge Healthcare , Brief Report , Institutional Review Board , Ficoll Paque Plus , National Health Commission , Ethics Committees , Israel Ministry , Infrared Imaging System , Src Protein , Protein Phosphorylation , Med Abstract , Crossref Full Text ,

Comparative analysis on confidential counselling for judges and for public prosecutors presented to the Serbian judiciary


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Belgrade
22 July 2021
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Members of the Ethics Committees of the Serbian High Judicial Council and the State Prosecutorial Council were presented with the 
The Council of Europe Group of States against Corruption GRECO, in the 4th Evaluation Round which deals with corruption prevention in respect of members of parliament, judges and prosecutors, made a recommendation to Serbian authorities that confidential counselling within the judiciary be provided for all categories of judges and public prosecutors. In that sense, the joint European Union/Council of Europe action “Strengthening independence and accountability of the judiciary” has put on disposal to both Councils the comparative analysis which examines the confidential counselling systems in a number of Council of Europe member-states, and beyond, in the US ....

United States , Mateus Cardoso , Mirjana Dokmanovic , High Judicial Council , Council Of Europe , Institute For Comparative Law , Prosecutorial Council , European Union Council Of Europe , Appellate Court , European Union , Council Of Europe Group States , Ethics Committees , Serbian High Judicial Council , State Prosecutorial Council , Europe Group , Evaluation Round , Manuel Duro Mateus Cardoso , Belgrade Based Institute , Comparative Law , Western Balkans , ஒன்றுபட்டது மாநிலங்களில் , மத்ேஉச் கார்டோசோ , உயர் நீதித்துறை சபை , சபை ஆஃப் யூரோப் , நிறுவனம் க்கு ஒப்பீட்டு சட்டம் , ஐரோப்பிய தொழிற்சங்கம் சபை ஆஃப் யூரோப் ,