Week 4: Oct. 3 at San Francisco 49ers, 1:05 p.m., FOX Seattle's first NFC West game comes against a 49ers squad looking to bounce back from an injury-plagued 6-10 2020 campaign. One big question is whether the Seahawks will be seeing Jimmy Garoppolo at QB or No. 3 pick Trey Lance. Week 5: Oct. 7 (Thursday) vs. Los Angeles Rams, 5:20 p.m., FOX/NFLN/Amazon** Seattle's first prime-time game is a clash between two 2020 playoff teams, and will be full of interesting storylines, including Seahawks offensive coordinator Shane Waldron and run game coordinator Andy Dickerson coaching against their former team, as well as Seattle's first look at a Rams offense with Matt Stafford at quarterback.