entresto helps improve your heart's ability to pump blood to the body. and with a healthier heart, there's no telling where life may take you. don't take entresto if pregnant; it can cause harm or death to an unborn baby. don't take entresto with an ace inhibitor or aliskiren, or if you've had angioedema with an ace or arb. the most serious side effects are angioedema, low blood pressure kidney problems, or high blood potassium. ask your doctor about entresto for heart failure. entrust your heart to entresto.