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First-of-its-kind study identifies 13 new Alzheimer's disease genes

First-of-its-kind study identifies 13 new Alzheimer’s disease genes
In the first study to use whole genome sequencing (WGS) to discover rare genomic variants associated with Alzheimer s disease (AD), researchers have identified 13 such variants (or mutations). In another novel finding, this study establishes new genetic links between AD and the function of synapses, which are the junctions that transmit information between neurons, and neuroplasticity, or the ability of neurons to reorganize the brain s neural network. These discoveries could help guide development of new therapies for this devastating neurological condition.
Researchers at Massachusetts General Hospital (MGH), the Harvard T. H. Chan School of Public Health, and Beth Israel Deaconess Medical Center report these findings in ....

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UCI-led team to address health impacts of adverse childhood experiences using precision medicine

UCI-led team to address health impacts of adverse childhood experiences using precision medicine
A collaborative team centered in the University of California, Irvine (UCI) and including Children s Hospital Orange County (CHOC) and Chapman University (CU) has been awarded a three-year grant totaling in excess of $2.3 million, to address the health impacts of adverse childhood experiences (ACEs) using precision medicine. Announced by the California Governor s Office of Planning & Research, in partnership with the Office of the California Surgeon General, the award is part of the California Initiative to Advance Precision Medicine (CIAPM). The research project will begin May 2021.
Led by Tallie Z. Baram, MD, PhD, Bren Distinguished Professor and director of the Conte Center at UCI, the UCI, CHOC and CU team has established two goals. The first is to identify the degree to which unpredictability of early life experiences interacts with established ACEs to influence children s ....

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Specific gene may play a causal role in heart disease independent of cholesterol levels

Specific gene may play a causal role in heart disease independent of cholesterol levels
High cholesterol is the most commonly understood cause of atherosclerosis, a hardening of the arteries that raises the risk of heart attack and stroke.
But now, scientists at Washington University School of Medicine in St. Louis have identified a gene that likely plays a causal role in coronary artery disease independent of cholesterol levels. The gene also likely has roles in related cardiovascular diseases, including high blood pressure and diabetes.
The study appears March 24 in the journal
Science Translational Medicine.
Studying mice and genetic data from people, the researchers found that the gene called SVEP1 makes a protein that drives the development of plaque in the arteries. In mice, animals missing one copy of SVEP1 had less plaque in the arteries than mice with both copies. The researchers also selectively reduced the protein in the arterial walls of mice, ....

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"Small" changes made with gene editing cause severe deformities in plants

Small changes made with gene editing cause severe deformities in plants
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Small changes made with gene editing cause severe deformities in plants
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New study points to unintended effects of gene editing in plants and potential negative effects on ecosystems
Gene editing causes drastic unwanted effects in gene-edited plants including severe deformities, a new scientific publication in the journal Environmental Sciences Europe shows. This is the case even when the changes are intended by the gene editor to be small tweaks to existing genes rather than, for example, the introduction of new genetic material.
More broadly, the study provides an overview of the negative effects on ecosystems that can result from the release of gene-edited plants. These unintended effects result from the intended changes induced by genome editing, which can affect various metabolic processes in the plants. ....

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Disrupted biochemical pathway can lead to the brain changes characteristic of bipolar disorder

Bipolar disorder affects millions of Americans, causing dramatic swings in mood and, in some people, additional effects such as memory problems. ....

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