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Temperature, latitude correlate with COVID-19 cases and mortality rates

With cities around the globe locking down yet again amid soaring COVID-19 numbers, could seasonality be partially to blame? New research from the University of Illinois says yes. ....

United States , United Kingdom , University Of Illinois , Gustavo Caetano Anoll , Emily Henderson , Department Of Crop Sciences , Evolutionary Bioinformatics , Crop Sciences , Genomic Biology , Public Health , Sars Cov 2 , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் , எமிலி ஹென்டர்சன் , துறை ஆஃப் பயிர் அறிவியல் , பரிணாம வளர்ச்சி உயிர் தகவலியல் , பயிர் அறிவியல் , உயிர் தகவலியல் , சர்வதேச பரவல் , பொது ஆரோக்கியம் ,

Innovative breakthrough promises to diagnose DNA rearrangement mutations

Innovative breakthrough promises to diagnose DNA rearrangement mutations
Doctors are increasingly using genetic signatures to diagnose diseases and determine the best course of care, but using DNA sequencing and other techniques to detect genomic rearrangements remains costly or limited in capabilities.
However, an innovative breakthrough developed by researchers at Virginia Commonwealth University Massey Cancer Center and the VCU Department of Physics promises to diagnose DNA rearrangement mutations at a fraction of the cost with improved accuracy.
Led by VCU physicist Jason Reed, Ph.D., the team developed a technique that combines a process called digital polymerase chain reaction (dPCR) with high-speed atomic force microscopy (HSAFM) to create an image with such nanoscale resolution that users can measure differences in the lengths of genes in a DNA sequence. These variations in gene length, known as polymorphisms, can be key to accurately diagnosing many forms of c ....

United States , Alden Chesney , Jason Reed , Amir Toor , Emily Henderson , School Of Medicine , College Of Humanities , Virginia Commonwealth University Massey Cancer Center , American Society Of Hematology , Department Of Pathology , Association Of Molecular Pathology , Professor In Department Of Physics , Department Of Physics , Member Of Cancer Biology Research Program , Massey Cancer Center , Molecular Pathology , American Society , Cancer Center , Cancer Biology Research Program , Associate Professor , Virginia Commonwealth , Developmental Therapeutics , Dna Sequencing , Atomic Force Microscopy , Polymerase Chain Reaction , ஒன்றுபட்டது மாநிலங்களில் ,

Salk scientists receive $1.2 million from Larry L. Hillblom Foundation to study aging mechanisms

Salk scientists receive $1.2 million from Larry L. Hillblom Foundation to study aging mechanisms
A collaborative team of Salk scientists led by Professor John Reynolds will receive $1.2 million over four years as part of a Network Grant from the Larry L. Hillblom Foundation to examine aging across the life span, including age-related neurodegenerative diseases such as Alzheimer s disease.
The research will advance our understanding of aging mechanisms at the cognitive, genomic and cellular levels with potentially direct translatability to humans. Other members of the team include Salk President and Professor Rusty Gage, Staff Scientist Uri Manor, Senior Staff Researcher Courtney Glavis-Bloom, and Carol Marchetto, an assistant professor at the University of California San Diego. ....

United States , University Of California San Diego , Carol Marchetto , John Reynolds , Courtney Glavis , Emily Henderson , Network Grant , Larryl Hillblom Foundation , Professor John Reynolds , Salk President , Professor Rusty Gage , Staff Scientist Uri Manor , Senior Staff Researcher Courtney Glavis Bloom , California San , Rusty Gage , Alzheimer 39s Disease , Neurodegenerative Diseases , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் டியாகோ , ஜான் ரெனால்ட்ஸ் , எமிலி ஹென்டர்சன் , வலைப்பின்னல் மானியம் , ப்ரொஃபெஸர் ஜான் ரெனால்ட்ஸ் , சாள்க் ப்ரெஸிடெஂட் , ப்ரொஃபெஸர் துருப்பிடித்தது கேஜ் , ஊழியர்கள் விஞ்ஞானி யூரி மேனர் ,

Early Release - Local Transmission of SARS-CoV-2 Lineage B.1.1.7, Brazil, December 2020 - Volume 27, Number 3—March 2021 - Emerging Infectious Diseases journal

4) for a multiple sequence alignment (
5) with the new sequences and 127 publicly available B.1.1.7 genomes from around the world available on GISAID (
6) as of December 31, 2020 (https://github.com/CADDE-CENTRE/VOC-Lineage-Brazil). The virus genome recovered from patient 1 grouped within a well-supported cluster (bootstrap 85%) of 10 sequences (60% from the United Kingdom) (Figure). This finding is consistent with the travel history of an asymptomatic family member who was positive for SARS-CoV-2 (according to a rapid test performed on December 23, 2020), who arrived in São Paulo on December 17 after traveling from Italy to the United Kingdom and, after a short stay, from London to São Paulo, and who was in close contact with patient 1. The sequence from patient 2 clustered with good statistical support (bootstrap 79.4%) with a sequence collected in the United Kingdom on November 27. Patient 2 had traveled from London to São Paulo on December 19 and was symptomatic whe ....

United States , United Kingdom , City Of , School Of Medicine Institute Tropical , Department Of Infectious Disease , Centre For Arbovirus Discovery , Thermo Fisher Scientific , Oxford Nanopore Technologies , Infectious Disease , Tropical Medicine , Arbovirus Discovery , 2019 Novel Coronavirus Disease , Coronavirus Disease , Covid 19 , Lineageb 1 7 , Respiratory Infections , Sars Cov 2 , Severe Acute Respiratory Syndrome Coronavirus 2 , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , நகரம் ஆஃப் , பள்ளி ஆஃப் மருந்து நிறுவனம் வெப்பமண்டல , துறை ஆஃப் தொற்று நோய் , தெர்மோ மீனவர் அறிவியல் , தொற்று நோய் , வெப்பமண்டல மருந்து ,

New study unravels complete sequence of DNA repair mechanism

New study unravels complete sequence of DNA repair mechanism
Every living organism has DNA, and every living organism engages in DNA replication, the process by which DNA makes an exact copy of itself during cell division. While it s a tried-and-true process, problems can arise.
Break-induced replication (BIR) is a way to solve those problems. In humans, it is employed chiefly to repair breaks in DNA that cannot be fixed otherwise. Yet BIR itself, through its repairs to DNA and how it conducts those repairs, can introduce or cause genomic rearrangements and mutations contributing to cancer development.
It s kind of a double-edged sword, says Anna Malkova, professor in the Department of Biology at the University of Iowa, who has studied BIR since 1995. The basic ability to repair is a good thing, and some DNA breaks can t be repaired by other methods. So, the idea is very good. But the outcomes can be bad. ....

University Of Iowa , United States , Weiwei Dang , Jerzy Twarowski , Zhenxin Yan , Grzegorz Ira , Hanzeng Li , Luyang Sun , Juraj Kramara , Emily Henderson , Liping Liu , Rajula Elango , Beth Osia , Rosemary Lee , Sandeep Kumar , Anna Malkova , Beth Israel Deaconess Medical Center , Harvard Medical School , Baylor College Of Medicine , Department Of Biology , Droplet Digital , Baylor College , Cell Division , Dna Replication , பல்கலைக்கழகம் ஆஃப் ஐயுவா , ஒன்றுபட்டது மாநிலங்களில் ,