Novel brain organoid model unveils link between inflammation and astrocyte dysfunction
The brain is typically depicted as a complex web of neurons sending and receiving messages. But neurons only make up half of the human brain.
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The brain is typically depicted as a complex web of neurons sending and receiving messages. But neurons only make up half of the human brain.
<p>Salk scientists discovered a pathway from mitochondrial DNA replication stress to immune system activation and inflammation, finding that endosomes responsible for disposing of dysfunctional mitochondrial DNA were leaking mitochondrial DNA into the cell and prompting the inflammatory immune response. The pathway provides new targets for therapeutics that disrupt inflammation during aging and disease.</p>
Cells in the human body contain power-generating mitochondria, each with their own mtDNA-;a unique set of genetic instructions entirely separate from the cell's nuclear DNA that mitochondria use to create life-giving energy.
Many scientists credit teenage jobs and university or summer side roles for imparting important transferable skills and valuable life experiences. Many scientists credit teenage jobs and university or summer side roles for imparting important transferable skills and valuable life experiences.
Brains are like puzzles, requiring many nested and codependent pieces to function well. The brain is divided into areas, each containing many millions of neurons connected across thousands of synapses.