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Novel brain organoid model unveils link between inflammation and astrocyte dysfunction

The brain is typically depicted as a complex web of neurons sending and receiving messages. But neurons only make up half of the human brain.

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Mitochondrial DNA Dysfunction Points to Potential Therapeutic Targets against Inflammation

Mitochondrial DNA Dysfunction Points to Potential Therapeutic Targets against Inflammation
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Inflammation Linked to Faulty DNA Disposal System

Inflammation Linked to Faulty DNA Disposal System
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Faulty DNA disposal system causes inflammatio

<p>Salk scientists discovered a pathway from mitochondrial DNA replication stress to immune system activation and inflammation, finding that endosomes responsible for disposing of dysfunctional mitochondrial DNA were leaking&nbsp;mitochondrial DNA into the cell and prompting the inflammatory immune response. The pathway provides new targets for therapeutics that disrupt inflammation during aging and disease.</p>


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Mitochondrial misfire sparks inflammation

Cells in the human body contain power-generating mitochondria, each with their own mtDNA-;a unique set of genetic instructions entirely separate from the cell's nuclear DNA that mitochondria use to create life-giving energy.

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Faulty DNA disposal system causes inflammation

Faulty DNA disposal system causes inflammation
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Faulty DNA disposal system causes inflammatio

Faulty DNA disposal system causes inflammatio
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Waiting on tables, mending puppets: the first jobs that shaped researchers' careers

Many scientists credit teenage jobs and university or summer side roles for imparting important transferable skills and valuable life experiences. Many scientists credit teenage jobs and university or summer side roles for imparting important transferable skills and valuable life experiences.

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Cracking the case of mitochondrial repair and replacement in metabolic stress

Cracking the case of mitochondrial repair and replacement in metabolic stress
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Mitochondria power-supply failure may cause age-related cognitive impairment: Scientists find mitochondria at dysfunctional synapses fail to meet energetic demand, supplying either too much or too little power and potentially causing age-related cognitive impairment

Mitochondria power-supply failure may cause age-related cognitive impairment: Scientists find mitochondria at dysfunctional synapses fail to meet energetic demand, supplying either too much or too little power and potentially causing age-related cognitive impairment
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