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Enzymatic danse macabre of lung cancer

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VIDEO: KAUST researchers used nuclear magnetic resonance spectroscopy to experimentally evaluate the structure and dynamics of the hyperactive mutant enzyme implicated in driving lung squamous cell carcinoma.
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Credit: © 2021 KAUST; Anastasia Serin.
A chromatin-regulating enzyme has been shown by in-depth interdisciplinary investigations to be a key driver of a common type of lung cancer. Drugs that target the enzyme could improve treatment and survival rates for this particular cancer.
Squamous cell carcinoma represents nearly one third of all lung cancers in humans, says KAUST structural biologist Lukasz Jaremko, who led the research along with colleagues at Stanford University and The University of Texas MD Anderson Cancer Center, U.S. Our joint structural and dynamics investigations, including enzymatic activity studies, genetic analyses, and mouse model and human cell results, all point to the enzyme histone-lysine N-meth ....

United States , Lukasz Jaremko , Vladlena Kharchenko , University Of Texas Md Anderson Cancer Center , Stanford University , Cancer Center , Biomedical Environmental Chemical Engineering , Cell Biology , Medicine Health , Pulmonary Respiratory Medicine , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , ஸ்டான்போர்ட் பல்கலைக்கழகம் , புற்றுநோய் மையம் , உயிரி தொழில்நுட்பவியல் , உயிர் மருத்துவ சுற்றுச்சூழல் இரசாயன பொறியியல் , செல் உயிரியல் , மருந்து ஆரோக்கியம் , நுரையீரல் சுவாச மருந்து , உயிர் தகவலியல் ,

Saarbrücken based bioinformaticians trace down molecular signals of Parkinson's disease

Credit: Oliver Dietze
In their study, which is now published in the journal
Nature Aging, they show that the level of non-coding RNAs in the blood of a Parkinson s patient can be used to track the course of the disease. For their study, the team led by bioinformatics professor Andreas Keller and his doctoral student Fabian Kern created and analyzed the molecular profiles of more than 5,000 blood samples from over 1,600 Parkinson s patients. This resulted in around 320 billion data points, which the researchers analyzed for biomarkers of Parkinson s disease using artificial intelligence methods. Our project is among the largest RNA biomarker studies in the world, says Andreas Keller, head of the research group for clinical bioinformatics at Saarland University and spokesperson for the Center for Bioinformatics at the Saarland Informatics Campus. ....

United States , Stanford University , University Of Southern California , San Diego , Fabian Kern , Los Angeles , Andreas Keller , University Of California , Saarland University , German Research Center , Parkinson Progression Markers Initiative , Translational Genomics Research Institute Tgen , Max Planck Institute For Software Systems , Centre For Systems Biomedicine , Max Planck Institute For Computer Science , Nature Aging , Saarland Informatics , Progression Markers Initiative , Systems Biomedicine , Translational Genomics Research Institute , Southern California , Saarland Informatics Campus , Artificial Intelligence , Max Planck Institute , Computer Science , Software Systems ,

New probe set unravels evolutionary history of second-most diverse group of land plants

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IMAGE: Flagellate plants are a diverse group with more than 30,000 living species, including ferns, lycophytes, bryophytes, and gymnosperms.
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Credit: Photos by Emily Sessa.
In 2016, a collaborative group of research and education specialists received funding from the National Science Foundation for the project Building a Comprehensive Evolutionary History of Flagellate Plants also known as Genealogy of Flagellate Plants (GoFlag). Members of the team have the ambitious goal of reconstructing the 470-million-year history of one of the most diverse groups of land plants on the planet.
The first of several forthcoming publications from the project was published in a recent issue of ....

United States , Gordon Burleigh , Wiley Online Library , Society Of America , University Of Florida , National Science Foundation , Applications In Plant Sciences , Comprehensive Evolutionary History , Flagellate Plant , Principal Investigator , Plant Sciences , Botanical Society , Wiley Online , Molecular Biology , Population Biology , ஒன்றுபட்டது மாநிலங்களில் , கோர்டந் பர்லீ , விலே நிகழ்நிலை நூலகம் , சமூகம் ஆஃப் அமெரிக்கா , பல்கலைக்கழகம் ஆஃப் புளோரிடா , தேசிய அறிவியல் அடித்தளம் , பயன்பாடுகள் இல் ஆலை அறிவியல் , விரிவான பரிணாம வளர்ச்சி வரலாறு , ப்ரிந்ஸிபல் புலனாய்வாளர் , ஆலை அறிவியல் , தாவரவியல் சமூகம் ,

Study reveals new clues about the architecture of X chromosomes

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BOSTON - Researchers at Massachusetts General Hospital (MGH) have uncovered new clues that add to the growing understanding of how female mammals, including humans, silence one X chromosome. Their new study, published in
Molecular Cell, demonstrates how certain proteins alter the architecture of the X chromosome, which contributes to its inactivation. Better understanding of X chromosome inactivation could help scientists figure out how to reverse the process, potentially leading to cures for devastating genetic disorders.
Female mammals have two copies of the X chromosome in all of their cells. Each X chromosome contains many genes, but only one of the pair can be active; if both X chromosomes expressed genes, the cell couldn t survive. To prevent both X chromosomes from being active, female mammals have a mechanism that inactivates one of them during development. X chromosome inactivation is orchestrated by a noncoding form of RNA called Xist, which sil ....

United States , Jeannie Lee , Andrea Kriz , Department Of Molecular Biology , Lee Laboratory , Genetics At Harvard Medical School , Massachusetts General Hospital , Molecular Cell , Molecular Biology , Harvard Medical , Sex Linked Conditions , ஒன்றுபட்டது மாநிலங்களில் , ஜீனி லீ , துறை ஆஃப் மூலக்கூறு உயிரியல் , லீ ஆய்வகம் , ஜெநெடிக்ஸ் இல் ஹார்வர்ட் மருத்துவ பள்ளி , மாசசூசெட்ஸ் ஜநரல் மருத்துவமனை , மூலக்கூறு செல் , மூலக்கூறு உயிரியல் , ஹார்வர்ட் மருத்துவ , செக்ஸ் இணைக்கப்பட்டுள்ளது நிபந்தனைகள் ,

Why does convalescent plasma therapy for severe COVID-19 show mixed success?

Why does convalescent plasma therapy for severe COVID-19 show mixed success?
Treatment modalities against the coronavirus disease 2019 (COVID-19) pandemic are limited in efficacy. This has led many centers to use convalescent plasma from recovered COVID-19 patients in the management of this condition.
A surprising new preprint, released on the
medRxiv server, suggests that the beneficial effects of convalescent plasma (CP) in this disease stem not only from the presence of neutralizing antibodies, but also the immunomodulatory effects of this plasma that shapes the host immune response.
Discrepancy in results from convalescent plasma trials
Randomized controlled trials have failed to yield evidence of significant benefit from CP when administered late in the course of illness. However, within three days of symptom onset, CP with high titers of antibodies led to a 73% reduction in the risk of progressive COVID-19. ....

Liji Thomas , Functional Antibodies , Image Credit , Fcr Binding Igg , N Specific Igg , S Specific Igg , Convalescent Plasma , Coronavirus Disease Covid 19 , Sars Cov 2 , Anti Inflammatory , Corona Virus , Immune Response , செயல்பாட்டு ஆன்டிபாடிகள் , படம் கடன் , ஃப்க்ர் பிணைப்பு இக் , ச்சனியான குறிப்பிட்ட இக் , கள் குறிப்பிட்ட இக் , சுறுசுறுப்பான பிளாஸ்மா , சர்வதேச பரவல் , எதிர்ப்பு அழற்சி , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் ,