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How Your Brain Registers Loneliness Could Have a Strange Link to Wisdom


How Your Brain Registers Loneliness Could Have a Strange Link to Wisdom
9 MARCH 2021
New insights into the neural activity linked to loneliness could help us improve the way we treat it, researchers say – and reduce the numerous physical and mental health impacts associated with feelings of being lonely.
 
Our brains react to loneliness in an almost exactly opposite way to the way they react to feelings of
wisdom, according to a new study. This adds to a growing body of research that suggests that the wiser we think we are, the less lonely we feel.
While the loneliness-wisdom association has been spotted before, this is the first time scientists have been able to look at the apparent link on the neural level. ....

Jyoti Mishra , Dilip Jeste , University Of California San Diego , California San Diego , Amp Quot , ஜையோடீ மிஸ்ரா , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் டியாகோ , கலிஃபோர்னியா சான் டியாகோ ,

A trio that could spell trouble: Many with dementia take risky combinations of medicines


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People over 65 shouldn t take three or more medicines that act on their brain and nervous system, experts strongly warn, because the drugs can interact and raise the risk of everything from falls to overdoses to memory issues.
But a new study finds that 1 in 7 people with dementia who live outside nursing homes are taking at least three of these drugs.
Even if they received the drugs to calm some of dementia s more troubling behavioral issues, the researchers say, taking them in combination could accelerate their loss of memory and thinking ability, and raise their chance of injury and death. ....

United States , Helen Kales , Erica Solway , Myra Kim , Julie Bynum , Kenneth Langa , Chiang Hua Chang , Donovan Maust , Stephen Marcus , Kara Zivin , University Of California , Va Center , Um Institute For Healthcare , Area Agency On , Clinical Management Research , University Of Michigan , University Of Pennsylvania , National Institute On Aging , Michigan Medicine , Area Agency , Um Institute , Healthcare Policy , National Institute , Medicine Health , Alzheimers Disease , Pharmaceutical Science ,

Amyloid plaque mutation map opens new avenues for early detection of Alzheimer's disease


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IMAGE: Mireia Seuma (left), first author of the study and researcher at IBEC next to Benedetta Bolognesi (right), one of the lead authors of the study and Junior Group Leader at.
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Credit: The Institute for Bioengineering of Catalonia, IBEC
A study published in the journal
eLife made all the possible mutations in the amyloid beta peptide and tested how they influence its aggregation into plaques, a pathological hallmark of Alzheimer s disease.
The comprehensive mutation map, which is the first of its kind, has the potential to help clinical geneticists predict whether the mutations found in amyloid beta can make an individual more prone to developing Alzheimer s disease later in life. ....

Benedetta Bolognesi , Mireia Seuma , Ben Lehner , Research Professor , Centre For Genomic Regulation , Institute For Bioengineering Of Catalonia , Junior Group Leader , Genomic Regulation , Variant Effects , Cell Biology , Molecular Biology , Alzheimers Disease , ஆராய்ச்சி ப்ரொஃபெஸர் , நிறுவனம் க்கு உயிர் பொறியியல் ஆஃப் கட்டலோனியா , ஜூனியர் குழு தலைவர் , மாறுபாடு விளைவுகள் , செல் உயிரியல் , மூலக்கூறு உயிரியல் , அல்சைமர் நோய் , உயிர் தகவலியல் ,

Study finds brain's 'wiring insulation' as major factor of age-related brain deterioration


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IMAGE: The image depicts myelin (Cyan) and specialised brain stem cells Oligodendrocyte Progenitor Cells (OPCs) in the grey and white matter of the brain. Myelin is an insulation produced by cells.
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Credit: Dr Andrea Rivera
A new study led by the University of Portsmouth has identified that one of the major factors of age-related brain deterioration is the loss of a substance called myelin.
Myelin acts like the protective and insulating plastic casing around the electrical wires of the brain - called axons. Myelin is essential for superfast communication between nerve cells that lie behind the supercomputer power of the human brain. ....

United Kingdom , Andrea Porzionato , Andrea Rivera , Kasum Azim , Emma Gray , Veronica Macchi , Maria Pia Abbracchio , German Research Council Dr Azim , University Of Portsmouth , Ms Society , Anatomical Society Phd Studentship , University Of Dusseldorf , University Of Padua , Swiss National Funds Fellowship , Multiple Sclerosis , Ageing Cell , Professor Arthur Butt , Professor Maria Pia Abbracchio , Professors Raffele De Caro , Human Anatomy , Professor Butt , Professors Butt , German Research Council , Assistant Director , Cell Biology , Medicine Health ,