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Slight differences can help distinguish between two similar pediatric brain conditions

Slight differences can help distinguish between two similar pediatric brain conditions
Slight differences in clinical features can help physicians distinguish between two rare but similar forms of autoimmune brain inflammation in children, a new study by UT Southwestern scientists suggests. The findings, published online in
Pediatric Neurology, could provide patients and their families with a better prognosis and the potential to target treatments specific to each condition in the future.
About half of all cases of encephalitis - a rare type of brain inflammation that affects about 1 of every 200,000 people in the U.S. each year - can be traced to an infection. For a portion of other cases in which the cause isn t initially clear, researchers have discovered a link with the patients own immune systems inappropriately targeting and damaging the brain. ....

Mollye Mcgetrick , Emily Henderson , Pediatric Neurology , Acute Disseminated Encephalomyelitis , எமிலி ஹென்டர்சன் , குழந்தை நரம்பியல் ,

Former FDA Commissioner Stephen Hahn joins Blackfynn's board of directors

Former FDA Commissioner Dr. Stephen Hahn is joining Blackfynn's board of directors. The Philadelphia-based therapeutics company combines data, technology and clinical expertise to develop therapies for Parkinson's disease and neurodegeneration. Hahn oversaw the regulatory process of the first COVID-19 vaccines. ....

University Of Pennsylvania , United States , Temple University , Stephen Hahn , Scott Gottlieb , National Institutes Of Health , White House Coronavirus Task , Drug Administration , Md Anderson Cancer Center , Philadelphia Va Medical Center , National Institutes , Cancer Center , Mayo Clinic , Health News , Covid 19 , Penn Medicine , Parkinson 39s Disease , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , ஒன்றுபட்டது மாநிலங்களில் , கோயில் பல்கலைக்கழகம் , ஸ்டீபன் ஹான் , ஸ்காட் காட்‌லீப் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , பிலடெல்பியா வா மருத்துவ மையம் , தேசிய நிறுவனங்கள் ,

„Fat jam" in the cell | EurekAlert! Science News

In the journal
Nature Communications, scientists of the German Center for Neurodegenerative Diseases (DZNE) report new findings on the mechanisms of Niemann-Pick type C disease (NPC). This rare brain disorder mainly manifests in childhood and includes severe neurological and psychiatric symptoms. Researchers led by Dr. Sabina Tahirovic have now found evidence that already at an early stage, NPC is associated with neuroinflammation and that this condition is triggered by impaired intracellular lipid transport. In addition, they identified pathological features in the blood of affected individuals that in the future could assist to better monitor the course of the disease and response to therapy. ....

Sabina Tahirovic , Nature Communications , Department Of Neurology , German Center , Neurodegenerative Diseases , Alessio Colombo , Medicine Health , இயற்கை தகவல்தொடர்புகள் , துறை ஆஃப் நரம்பியல் , ஜெர்மன் மையம் , Alessio கொழும்பு , மருந்து ஆரோக்கியம் , குழந்தை மருத்துவம் ,

CUHK study brings new direction for treating neurological diseases

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IMAGE: Under normal situation (image on the left), the closely packed choroid plexus restrains molecules in the blood stream from entering the CSF freely; the loss of SOX9 function (image on.
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Credit: CUHK
The finding, recently published in the prestigious scientific journal
Proceedings of the National Academy of Sciences of the United States of America (PNAS), has provided the scientific community a novel understanding to the molecular regulatory mechanisms behind the function of the blood-CSF barrier and lays the groundwork for developing novel therapeutic strategies for preventing and treating neurodevelopmental disorders.
Dysfunction of blood-cerebrospinal fluid barrier is common in various neurological diseases ....

United States , Hong Kong , Jiang Liwen , School Of Life Sciences , Collaborative Research Fund , Key Laboratory Of Agrobiotechnology , School Of Life Science , Research Fund , Centre For Cell , National Academy , Associate Professor , Life Science , Professor Jiang Liwen , Professor Ngai Sai Ming , Professor Hui Ho Lam Jerome , Life Sciences , General Research Fund , Hong Kong Research Grants Council , Developmental Biology , State Key Laboratory , Medicine Health , ஒன்றுபட்டது மாநிலங்களில் , ஹாங் காங் , பள்ளி ஆஃப் வாழ்க்கை அறிவியல் , கூட்டு ஆராய்ச்சி நிதி , ஆராய்ச்சி நிதி ,

A combination therapy for treating severe neurological childhood disorders

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A study aiming to develop a new therapeutic technique could bring a revolution in our approach to treating rare, fatal Sanfilippo syndrome, a disorder that affects children as young as 2 years old and leads to childhood dementia and premature death.
We are using a combination of gene therapy, stem cells and small molecules to restore metabolic defects in the patient s brain cells says Dr. Alexey Pshezhetsky, Professor at CHU Ste-Justine and lead GlycoNet Investigator on this project. First results in the mouse models of the disease are very encouraging.
Sanfilippo syndrome belongs to a group of rare diseases known as lysosomal storage disorders. ....

Alexey Pshezhetsky , Jonah Just Begun Foundation United States , Phenix Nest Inc , Sanfilippo Children Research Foundation Canada , Glyconet Investigator , Ashkenazi Jewish , French Canadians , Sanfilippo Children , Research Foundation , Just Begun Foundation , United States , Cell Biology , Medicine Health , Metabolism Metabolic Diseases , Technology Engineering Computer Science , ஜோனா வெறும் தொடங்கியது அடித்தளம் ஒன்றுபட்டது மாநிலங்களில் , பினிக்ஸ் கூடு இன்க் , சான்ஃபிலிப்போ குழந்தைகள் ஆராய்ச்சி அடித்தளம் கனடா , பிரஞ்சு கனடியர்கள் , சான்ஃபிலிப்போ குழந்தைகள் , ஆராய்ச்சி அடித்தளம் , வெறும் தொடங்கியது அடித்தளம் , ஒன்றுபட்டது மாநிலங்களில் , உயிரி தொழில்நுட்பவியல் , செல் உயிரியல் , மருந்து ஆரோக்கியம் ,