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Scientists map the brain of a nematode worm

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IMAGE: The spatial organisation of the C. elegans brain is modular. The image shows the different brain regions that process information to direct behaviours such as navigation, avoidance and feeding. The.
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Credit: University of Leeds
Researchers have mapped the physical organization of the brain of a microscopic soil-living nematode worm called
Caenorhabditis elegans, creating a new model for the architecture of the animal s brain and how it processes information.
In a surprise twist, they found a large degree of variation in the structure of some neural circuits or pathways in individual worms which complemented a core set of neural circuits common to different animals. ....

United Kingdom , Northern Ireland , Netta Cohen , Christopher Brittin , David Lewis , Rosalind Franklin , Research Excellence Framework , York Albert Einstein College Of Medicine , University Of Leeds , National Teaching Fellowships , Qs World University Rankings , Russell Group , New York , Albert Einstein College , Computational Neuroscientist , Excellence Framework , University Rankings , Teaching Excellence Framework , Developmental Reproductive Biology , Computer Science , Multimedia Networking Interface Design , ஒன்றுபட்டது கிஂக்டம் , வடக்கு ஐயர்ல்யாஂட் , நெட்டா கோஹன் , கிறிஸ்டோபர் பிரிட்டின் , டேவிட் லெவிஸ் ,

Uncovers the molecular mechanism behind synapse loss in Alzheimer's disease

Credit: KOREA BRAIN RESEARCH INSTITUTE
Korea Brain Research Institute (KBRI, Pann-Ghill Suh (President)) announced that Dr. Kea Joo Lee and Dr. You-Na Jang of the Neural Circuits Research Group have identified the mechanism causing synaptic loss in Alzheimer s disease as the aberrant expression of RAPGEF2, a synaptic protein.
- The results were published on January 2021, in the online Early View of
Neuropathology and Applied Neurobiology.
(Title) RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer s disease
Alzheimer s disease (AD) accounts for about 75% of dementia cases and is the most common type of degenerative brain disease. AD is a devastating because disease progression can cause memory loss, mood disorder, slurred speech, confusion, and impaired movement. ....

South Korea , Kea Joo Lee , Pann Ghill Suh , National Research Foundation Of Korea , Korea Brain Research Institute , Neural Circuits Research Group , You Na Jang , Early View , National Research Foundation , Medicine Health , Alzheimers Disease , தெற்கு கொரியா , கீ ஜூ லீ , தேசிய ஆராய்ச்சி அடித்தளம் ஆஃப் கொரியா , கொரியா மூளை ஆராய்ச்சி நிறுவனம் , நரம்பியல் சுற்றுகள் ஆராய்ச்சி குழு , நீங்கள் நா ஜங் , ஆரம்ப பார்வை , தேசிய ஆராய்ச்சி அடித்தளம் , மருந்து ஆரோக்கியம் , அல்சைமர் நோய் ,

Building a brain: Pioneering study reveals principles of brain tissue structure, assembly

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VIDEO: Volumetric reconstruction of the L4 C. elegans neuropil (from EM serial sections) with neurons from the four strata highlighted (S1-Red, S2-Purple, S3-Blue, S4-Green).
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Credit: Mark Moyle et al., Nature, 2021.
WOODS HOLE, Mass. Understanding how the brain works is a paramount goal of medical science. But with its billions of tightly packed, intermingled neurons, the human brain is dauntingly difficult to visualize and map, which can provide the route to therapies for long-intractable disorders.
In a major advance published next week in Nature, scientists for the first time report the structure of a fundamental type of tissue organization in brains, called neuropil, as well as the developmental pathways that lead to neuropil assembly in the roundworm ....

New York , United States , Woods Hole , Marine Biological Laboratory , John White , Abhishek Kumar , Sydney Brenner , Zhirong Bao , Williama Mohler , Smita Krishnaswamy , Mark Moyle , Hari Shroff , Development Of The Nerve Ring , Yale School Of Medicine , National Institute Of Biomedical Imaging , University Of Connecticut Health Center , Sloan Kettering Institute , University Of Chicago , Daniel Col , Yale School , National Institute , Biomedical Imaging , East Side , West Side , Connecticut Health , Cell Biology ,

Yale scientists capture the choreography of a developing brain

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IMAGE: Yale researchers and collaborators have devised a strategy that allows them to see this previously impenetrable process unfold in a living animal the worm Caenorhabditis elegans, they report February.
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Credit: The work is the result of a decade long collaboration between the labs of Colón-Ramos and Smita Krishnaswamy of Yale; Hari Shroff of the National Institutes of Health; Zhirong Bao.
The formation of a brain is one of nature s most staggeringly complex accomplishments. The intricate intermingling of neurons and a labyrinth of connections also make it a particularly difficult feat for scientists to study. ....

New York , United States , Zhirong Bao , Williama Mohler , Dorys Mcconnell Duberg , Smita Krishnaswamy , Mark Moyle , Hari Shroff , University Of Connecticut Health Center , Yale School Of Medicine , Sloan Kettering Institute , National Institutes Of Health , Yale School , Daniel Col , Dorys Mcconnell Duberg Professor , Cell Biology , Wall Street , National Institutes , Connecticut Health , Medicine Health , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , ஸ்மிதா கிருஷ்ணசாமி , குறி மாய்ல் , ஹரி ஷ்ரொப்ப் , பல்கலைக்கழகம் ஆஃப் கனெக்டிகட் ஆரோக்கியம் மையம் ,

Reactivating aging stem cells in the brain

As people get older, their neural stem cells lose the ability to proliferate and produce new neurons, leading to a decline in memory function. Researchers at the University of Zurich have now discovered a mechanism linked to stem cell aging - and how the production of neurons can be reactivated. ....

Sebastian Jessberger , Brain Research Institute , Cell Biology , Molecular Biology , Medicine Health , Alzheimers Disease , Mental Health , மூளை ஆராய்ச்சி நிறுவனம் , செல் உயிரியல் , மூலக்கூறு உயிரியல் , மருந்து ஆரோக்கியம் , அல்சைமர் நோய் , மன ஆரோக்கியம் ,